Clinical trials: Muscle Loss
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Chronic Kidney Diseases, Sarcopenia
Multimorbidity and Sarcopenia Feasibility Study in Chronic Kidney Disease
The aim of this research study is to look at the body composition (such as muscle and fat) in people with chronic kidney disease (CKD) and comparing it with body composition is people without CKD.
- Trial name
- MaSS-CKD (NCT06109662)
- Testing
- Cystatin C eGFR, Bioimpedance Analysis (Body composition analysis)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Lower Limb Loss
Musculoskeletal Measurements in Transfemoral Amputees
The aim of this study was to identify posture asymmetries in transfemoral amputees utilizing clinical evaluation measures. The purposes of this investigation were: 1) to measure the limb length indirectly to determine the…
- Trial name
- NCT00909922
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Miami VA Healthcare System
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Aging
The UNCODE Study: Unravelling the Neural Contributors Of Dynapenia in Elders
The UNCODE Study seeks to better identify the neurological causes of muscle weakness associated with advancing age. The main study consists of 4 laboratory-based testing sessions that involve testing muscle strength and physical…
- Trial name
- NCT02505529
- Testing
- Resistance Exercise Training, Mental Imagery
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ohio University
Sarcopenia
RELIEF - Resistance Training for Life
Sarcopenia is an age-related gradual loss of muscle mass and strength and is associated with physical disability and mortality risk.
- Trial name
- RELIEF (NCT05063279)
- Testing
- Progressive resistance training
- Where
- Norway
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Stian Ellefsen
Breast Cancer Survivorship, Sarcopenia
Nutrition, Exercise, and Breast Cancer Survivorship
The purpose of the study is to examine the effects of resistance training on the reasons (mechanisms) underlying the development of fatigue, muscle weakness and wasting (sarcopenia), and impaired physical functioning (poor…
- Trial name
- NCT01151488
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Spinal Muscular Atrophy (SMA)
An International Federated Model for Wearable-derived Remote Longitudinal Motor Monitoring in Young Children With Spinal Muscular Atrophy Compared With Healthy Controls: Active-NBS Study (UK)
Active-NBS is a study to evaluate the muscle development of patients with spinal muscular atrophy (SMA) who are diagnosed at birth. Medicines have become available in the last decade, and many patients are treated very early.
- Trial name
- Active-NBS UK (NCT07543003)
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sarcopenia
Exercise Intermittent Isometric Handgrip and Blood Flow Restriction
Isometric handgrip exercises are used to explain the effects of fatigue on the strength and activation of the muscles involved. Blood flow available at the time of exercise can influence this fatigue process, as some studies…
- Trial name
- NCT02384161
- Testing
- Isometric exercise Intermittent
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Cancer, Muscle Atrophy
Influence of Motor Proteins on Muscle Atrophy in Cancer Patients
The aim of the study is to investigate the effect of exercise in form of whole-body electromyostimulation (WB-EMS) on early tumor-induced muscular dysfunction.
- Trial name
- NCT03551990
- Testing
- whole-body electromyostimulation WB-EMS
- Where
- Germany
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Sarcopenia, Dietary Protein
Dietary Protein Quality for Skeletal Muscle Anabolism in Older Adults
Dietary proteins potently augment muscle protein synthesis. Because of poorer anabolic sensitivity with ageing, studies and guidelines recommend higher dietary protein intake for older adults.
- Conditions
- Sarcopenia, Dietary Protein, Resistance Exercise
- Trial name
- NCT05574205
- Testing
- Resistance Exercise, Protein supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Exercise Training, Skeletal Muscle
Resistance Training, Detraining, and Retraining Study 2022
The research project is aiming to examine the muscular adaptations to resistance training (RT), detraining (DT) and repeated RT (i.e. retraining).
- Conditions
- Exercise Training, Skeletal Muscle, Skeletal Muscle Atrophy
- Trial name
- TraDeRe2022 (NCT05553769)
- Testing
- Resistance training, detraining, retraining
- Where
- Finland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Advanced Lung Cancer, Sarcopenia
Differences in Rate of Decline in CT-defined Skeletal Muscle Mass and Physical Performance in Patients With Advanced Non-small Cell Lung Cancer Receiving Chemotherapy and Targeted Therapy/Immunotherapy, Before and After Treatment.
Lung cancer is a common disease leading to 18 % of cancer deaths worldwide. Despite various improvement in treatment, there still remains low 5-year survival rate of 10-20 % in advanced lung cancer patients.
- Trial name
- NCT06326086
- Testing
- Chemotherapy drug, Targeted Agent, Immunotherapy
- Where
- Thailand
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
PreDiabetes, Older Adults
Vivo Prediabetes Study: Online, Live, and Interactive Strength Training for Older Adults With Prediabetes
This research trial studies the effect of an online, live and interactive strength training program on physical function and strength in older adults with prediabetes.
- Conditions
- PreDiabetes, Older Adults, Muscle Loss, Muscle Weakness
- Trial name
- NCT05497960
- Testing
- Vivo workout
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eric Levian
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Osteoarthritis, Sarcopenia
To Investigate Effects of Amway Bundle Combination of Products on Osteoarthritis & Sarcopenia
The goal of this interventional study is to evaluate the effects of bundle combination of Amway All-plant protein booster with Nutrilite Lifestyle guideline and/or EMS (Electric Muscle Stimulation) device on Osteoarthritis \&…
- Trial name
- NCT05872360
- Testing
- Bundle Group 1 with Nutrilite Lifestyle, Bundle Group 2 without Nutrilite Lifestyle, Control Group 1
- Where
- 2 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Amway (China) R&D Center
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Aging
Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older Adults
The purpose of this study is to determine whether treatment of healthy older men and women with oral MK-677 for 12 months will enhance pulsatile GH release and increase mean GH and IGF-I concentrations into the range of young…
- Trial name
- MOT089 (NCT00474279)
- Testing
- Orally active growth hormone secretagogue (MK-677)
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Muscle Atrophy, Muscle Weakness
FIT Exercise in 30d of ULLS-induced Muscle Disuse
This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical…
- Trial name
- NCT06631053
- Testing
- velocity-based FIT (VBFIT), No Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lance Bollinger
Myelomeningocele, Spinal Cord Injury
Reciprocating Gait Orthoses for Paraplegia Patients
Ambulation would bring many physiological and psychological benefits and getting up and walking has been a dream for paraplegia patients.The reciprocating gait orthoses (RGOs) for paraplegics particularly draws research…
- Conditions
- Myelomeningocele, Spinal Cord Injury, Spinal Muscular Atrophy
- Trial name
- UPGO (NCT02227407)
- Testing
- RGOs(reciprocating gait orthoses)
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital