Clinical trials: Muscle Loss
Exercise Training and Sarcopenia
Time Efficient Exercise to Reverse Sarcopenia and Improve Cardio-metabolic Health
Participants will be 60-80 y men and women who vary their physical activity (steps/day) while their lipid metabolism is studied (n=24).
- Trial name
- NCT04641117
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Sarcopenia, Elderly
Alternative to Gait Speed in Sarcopenia Assessment
This study aims to assess the reliability of the Elbow Performance Test as an upper extremity-based alternative for evaluating sarcopenia severity.
- Trial name
- NCT07065448
- Testing
- physical performance tests
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sarcopenia
A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
- Trial name
- NCT05869526
- Testing
- Fish oil, Kril oil, Vegetable oil
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Aging
Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older Adults
The purpose of this study is to determine whether treatment of healthy older men and women with oral MK-677 for 12 months will enhance pulsatile GH release and increase mean GH and IGF-I concentrations into the range of young…
- Trial name
- MOT089 (NCT00474279)
- Testing
- Orally active growth hormone secretagogue (MK-677)
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Muscular Atrophy, Spinal, Child, Only
Procedural Sedation for Pediatric Patients With Spinal Muscular Atrophy
Background and Aim: Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by progressive symmetrical weakness and atrophy of proximal muscles causing from degeneration of anterior horn cells of spinal cord.
- Conditions
- Muscular Atrophy, Spinal, Child, Only, Anesthesia
- Trial name
- NCT05291962
- Testing
- Retrospective observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Muscular Atrophy
Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men
Muscle size declines at around 0.5-1% per year after 50 years of age, with muscle strength declining up to twice as fast as muscle size.
- Trial name
- NCT02495727
- Testing
- Step-reduction, Pre-training, Exercise snacking
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bath
Sarcopenia, Diabetes Mellitus
Glucose Metabolism, Muscle Mass/Function and Inflammation in the Elderly
A thorough characterization of glucose metabolism and "inflammaging" in elderly subjects will help determine to what extent each of these factors affects muscle mass/function and contributes to age-related muscle wasting.
- Trial name
- NCT02426073
- Where
- 2 sites in Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sarcopenia
Regime for Vitamin D Maintenance in Post-Operative Patients
Vitamin D plays a significant part calcium and phosphate haemostasis, thus, intrinsically critical for bone health. Increasing evidence also reveal that insufficient serum vitamin D levels also result in poor muscle health with…
- Trial name
- D-ECISIVE (NCT06708741)
- Testing
- Vitamin D
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Rotator Cuff Tears, Motor Imagery
Does MI Have a Therapeutic Role in Arthroscopic Rotator Cuff Repair?
Objective: The aim of this study is to investigate the effect of motor imagery on muscle activity, pain, and function in arthroscopic rotator cuff repair.
- Conditions
- Rotator Cuff Tears, Motor Imagery, Muscle Activity, Atrophy, Muscular
- Trial name
- NCT05670080
- Testing
- Motor Imagery, Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Obesity, Glucose Intolerance
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of impaired glucose tolerance…
- Conditions
- Obesity, Glucose Intolerance, Exercise Capacity
- Trial name
- NCT00971594
- Testing
- Dietary counseling, AEX
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Sarcopenia
The Benefits of Hemp Protein Supplementation During Resistance Training
Forty physically active men and women aged 18-45y will take part in an 8-week resistance training program, randomized (double blind) 1:1 into each of two groups.
- Trial name
- NCT02529917
- Testing
- Hemp powder, Soy Powder
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Aging, Sarcopenia
Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity
The goal of this interventional study is to learn about the role of mitochondrial function in healthy aging, and then go on and assess the role of a home-based exercise program on the changes seen.
- Trial name
- Mi-HIIT (NCT05934760)
- Testing
- High intensity interval training (HIIT), Resistance based training (RET)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Aging, Muscle Loss
Protein Intake and Step Reduction in Older Adults
Sarcopenia, the loss in muscle mass with age, is associated with several negative health outcomes including cancer, stroke, cardiovascular disease and diabetes.
- Trial name
- DRI (NCT03285737)
- Testing
- Whey, Collagen
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Malnutrition, Sarcopenia
Health and Nutrition Status of Chinese Elderly
This study is aiming to understand the prevalence and risk factors related to malnutrition and sarcopenia in Chinese elderly.
- Trial name
- NCT02089906
- Where
- 3 sites in China
- Volunteers
- 2,834 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Obesity, Cardiovascular Disease
IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial
As individuals age, their physical activity decreases and sedentary time increases. Even small changes in these two behaviors can greatly decrease risks for several major health problems, including cardiovascular disease…
- Conditions
- Obesity, Cardiovascular Disease, Cancer, Diabetes
- Trial name
- IMPACT (NCT01869348)
- Testing
- Monitor intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Sarcopenia, Atrophy
Leucine Supplementation in Elderly Men
In the present study the investigators aim to determine whether leucine supplementation can augment muscle mass and strength and improve body composition in healthy elderly men
- Conditions
- Sarcopenia, Atrophy, Aging
- Trial name
- NCT00807508
- Testing
- leucine
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Spinal and Bulbar Muscular Atrophy, Kennedys Disease
Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)
Background: SBMA is an inherited chronic disease. It affects males in mid to late adulthood. It causes slowly progressive weakness of muscles and hand tremors. Researchers want to learn more about the effects of SBMA.
- Conditions
- Spinal and Bulbar Muscular Atrophy, Kennedys Disease, Motor Neuron Disease
- Trial name
- NCT04944940
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Muscle Loss, Fractures
Musculoskeletal Effects of Bicarbonate
With aging, men and women develop a mild and progressive metabolic acidosis. This occurs as a result of declining renal function and ingestion of acid-producing diets.
- Conditions
- Muscle Loss, Fractures, Osteoporosis, Age Related, Fall Injury
- Trial name
- NCT01475214
- Testing
- potassium bicarbonate
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Tufts University
Sarcopenia in Elderly
The Effect of Adding Elastic Resistance Training in Routine Physical Exercise on Walking Speed of Elderly People With Sarcopenia in Griya Wreda Jambangan, Surabaya
The goal of this randomized clinical trial is to learn whether adding elastic resistance training (ERT) to routine physical exercise can improve walking speed in older adults aged 60 years or older with sarcopenia living at Griya…
- Trial name
- NCT07859969
- Testing
- Elastic Resistance Training, Routine Physical Exercise
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
Colorectal Cancer, Exercise, Aerobic
Pedaling at a Low-Moderate Intensity During Chemotherapy Administration
The purpose of this study is to evaluate the feasibility of completing a low-moderate intensity pedaling session concurrent to chemotherapy treatment for colorectal cancer.
- Conditions
- Colorectal Cancer, Exercise, Aerobic, Chemotherapy, Chemotherapeutic Toxicity
- Trial name
- NCT04258969
- Testing
- Pedaling
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center