Clinical trials: Muscle Protein Synthesis
Insulin Sensitivity
mTOR as Mediator of Insulin Sensitivity Study
The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise.
- Trial name
- NCT05233722
- Testing
- Exercise, Insulin infusion, Rapamycin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Dietary Supplementation, Exercise
Resistance Exercise-induced Anabolism in Youths and Adults
Resistance exercise training (RET) in children and adolescents has become a popular area of research, with a growing body of evidence supporting its use.
- Trial name
- NCT06256744
- Testing
- exercise
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brock University
Sarcopenia
Dietary Strategies to Promote Muscle Protein Anabolism in the Elderly
Aging is associated with the loss of lean muscle mass, termed sarcopenia. Food intake and in particular the ingestion of protein or amino acids has been shown to be a powerful stimulus to promote net muscle protein anabolism.
- Trial name
- NCT00557388
- Testing
- Protein/Amino Acids, Physical exercise
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Older Adults Without Any Specific Clinical Condition
Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults
Healthy older adults and those who have acute and chronic conditions suffer from reduced protein intake and are at risk of developing both chronic and acute sarcopenia.
- Trial name
- NCT07754760
- Testing
- Essential amino acid supplement
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Shoulder Pain
Effects of Inhibition Techniques Applied on Trigger Points of Supraspinatus Muscle on Echogenicity and Patients' Pain
Trigger points (TP) are described as "hard, palpable nodules located within the taut bands of skeletal muscle". The aim of this study is to evaluate the reproductibility of palpation of TP between osteopaths and to compare this…
- Trial name
- NCT05951218
- Testing
- inhibition technique
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Institut des Hautes Etudes Osteopathiques de Nantes
Nutrition, Healthy
Aminoacidemia and Protein Kinetics in Response to the Ingestion of Plant-based Protein Blends
The present investigation aims to study a novel plant based protein isolate blend to determine if it results in similar muscle building responses compared to whey protein isolate.
- Trial name
- PBP (NCT05139160)
- Testing
- Protein quality
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy
Effect of Nutrition on Muscle Protein Synthesis
The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities.
- Trial name
- NCT00604929
- Testing
- carbohydrate and protein
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Energy Deficit
Effects of Essential Amino Acid-enriched Whey and Carbohydrate Co-ingestion on Protein Kinetics
Previous work conducted by the Investigators demonstrates that an essential amino acid(EAA)-enriched whey protein combination format is an efficient EAA/protein format to support enhanced whole-body protein balance and sustain…
- Trial name
- NCT04621175
- Testing
- EAA+W & Carbohydrate, EAA+W & EAA
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Overweight and Obesity
GRK-Biased Activation Via β2-Adrenergic Receptors in Human Skeletal Muscle
This longitudinal mechanistic physiological study examines biased β2-adrenergic receptor (β2-AR) signaling in human skeletal muscle, with emphasis on G protein-coupled receptor kinase (GRK)-mediated pathways.
- Trial name
- GAIN (NCT07421024)
- Testing
- ATR-258
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Health, Recreational Activities
Improving the Anabolic Action of Plant-based Foods Using Complementary Proteins
In a crossover design 10 young healthy adults (20-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise.
- Conditions
- Health, Recreational Activities, Muscle Protein Synthetic Response to Protein, Muscle Protein Synthesis
- Trial name
- CompProtein (NCT06781723)
- Testing
- Resistance Exercise, Isolated Mixture, Rice and Beans
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Muscle, Skeletal, High-Intensity Interval Training
Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT
High intensity interval training (HIIT) has recently emerged as a time efficient alternative to conventional endurance exercise, conferring similar or superior benefits in terms of metabolic and performance adaptations in both…
- Conditions
- Muscle, Skeletal, High-Intensity Interval Training, Exercise
- Trial name
- NCT03570424
- Testing
- Nutrient support to HIIT
- Where
- Ireland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Overweight and Obesity
The Effect of Very Low Calorie Diet With and Without Exercise on Muscle Synthesis in Middle-aged Overweight Male.
The aims of this project are: to investigate the impact of VLCD on control of muscle protein synthesis, muscle structure and function, cardiac function (ejection fraction), vascular function (blood flow and capillary function)…
- Trial name
- VLCDex (NCT03116256)
- Testing
- Very low calorie diet (VLCD), High intensity interval training (HIIT), Resistance exercise training (RET)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Wasting
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years).
- Trial name
- SPRINT (NCT07062562)
- Testing
- NMES, Protein bolus (20g), Standard nutrition
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Muscle Protein Synthesis
Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates
Rationale: Protein ingestion stimulates muscle protein synthesis and augments the muscle protein synthetic response to a single exercise session.
- Trial name
- Blend (NCT05386771)
- Testing
- Whey/collagen protein blend, Resistance exercise
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
The Effect of Menstrual Cycle Phase and Protein Dose on Muscle Protein Synthesis
Adaptation to resistance exercise requires maximal rates of muscle protein synthesis, which can be achieved with post-exercise ingestion of ~20g of protein.
- Trial name
- NCT05178732
- Testing
- Dose of protein, Menstrual cycle phase
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Interventional
Influence of Leucine Enriched Amino Acids on Myofibrillar and Collagen Protein Synthesis
The primary objective will be to determine the effect of leucine-enriched essential amino acids (LEAA) compared to carbohydrate placebo on dietary incorporation of [D5] Phenylalanine \& [D5] Glycine into the three skeletal muscle…
- Trial name
- NCT05554653
- Testing
- Leucine enriched amino acids
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Daniel Moore
Amino Acids, Dietary Protein
Influence of Sex and Training on de Novo Muscle Protein Synthesis
Acute exercise increases the incorporation of dietary amino acids into de novo myofibrillar proteins after a single meal in controlled laboratory studies in males.
- Conditions
- Amino Acids, Dietary Protein, Sex, Resistance Exercise
- Trial name
- TUT (NCT04887883)
- Testing
- Resistance exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Myotonic Dystrophy 1
Myotonic Dystrophy Type 1 and Resistance Exercise
The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1.
- Trial name
- STYRK DM1 (NCT05036447)
- Testing
- Moderate-Heavy Resistance Exercise
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University