Clinical trials: Muscle Protein Synthesis
Muscle Synthesis
Protein Blends (Soy, Whey and Casein) for Muscle Synthesis
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow).
- Trial name
- NCT01358305
- Testing
- Protein Blend
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Healthy
Amino Acid Profile and Muscle Protein Synthetic Response to Consuming Meat or Plant-based Alternatives
The purpose of the study is to quantify and compare the serum amino acid profile, and muscle protein synthesis rates, in response to consuming isonitrogenous amounts of ground meat (beef and pork) or plant-based alternatives…
- Trial name
- NCT04784806
- Testing
- Ground beef, Ground pork, Tofu
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Exercise Recovery
Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates
The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes.
- Trial name
- NCT00975390
- Testing
- Carbohydrate, Carbohydrate and protein ingestion, Carbohydrate and caffeine ingestion
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Loss
Muscle Protein Synthesis in Dialysis Patients
The most severe form of chronic renal failure is end-stage-renal-disease with maintenance hemodialysis (MHD) as the most common treatment strategy.
- Trial name
- NCT03478722
- Testing
- Protein Meal, Stable Isotope Amino Acid Infusion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Kidney Diseases, Muscle Loss
Protein and Exercise Training in Chronic KIDNEY Disease
When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent.
- Trial name
- PET KIDNEY (NCT05482243)
- Testing
- Whey protein
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response
Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response…
- Trial name
- BPM (NCT04894747)
- Testing
- Bolus ingestion of protein
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy Elderly Muscle, Anabolically Resistant Elderly Muscle
Protein Nutrition for Muscle Hypertrophy in Older Adults
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.
- Trial name
- NCT02315391
- Testing
- isolated whey protein, micellar whey protein, glycine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Muscle Protein Synthesis
Anabolic Properties of Canola
Muscle tissue consists of proteins. These proteins are built up of small building blocks: amino acids. By consuming enough protein in our diet, we make sure that the body is provided with enough amino acids to facilitate muscle…
- Trial name
- ALPACA (NCT05664269)
- Testing
- drink ingestion, resistance-type exercise
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Focus: Anabolic Response to Food Intake in Young Individuals, Condition Relevance: Skeletal Muscle Health, Sarcopenia
Manipulation of Dietary Protein and the Anabolic Response
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.
- Trial name
- PRO-ADAPT (NCT01820975)
- Testing
- High protein intake
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Omega-3 Fatty Acids and Muscle Protein Synthesis
The purpose of this study is to determine whether omega-3 fatty acid supplementation influences muscle protein synthesis rates in young and older adults.
- Trial name
- NCT00794079
- Testing
- omega-3 fatty acids, corn oil
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Vitamin D Effects on MPS, Placebo Effects on MPS
Effects of Vitamin D Supplementation on Muscle Protein Synthesis
Background: Healthy adults maintain muscle tissue by continuously building up and breaking down muscle proteins throughout the day.
- Trial name
- VIPER (NCT06746389)
- Testing
- 3000 IU per Day Spray
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia
Passive Heat Treatment and Skeletal Muscle Reconditioning Older Adults
Rationale: Aging is accompanied by impairments in the sensitivity of skeletal muscle tissue to respond to the anabolic properties of protein feeding, which is suggested to result in age-related loss in muscle mass.
- Trial name
- Sauna (NCT05129995)
- Testing
- Passive heat treatment
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthetic Response to Protein
Nutritional and Physical Intervention During Bed Rest
Hospitalization often involves long periods of bed rest and reduced nutritional intake, which can lead to skeletal muscle loss and anabolic resistance.
- Trial name
- Bed-Plant (NCT07280819)
- Testing
- Nutritionally complete tube feed providing a sole source of nutrition with a plant-dominant protein mix, Nutritionally complete tube feed providing a sole source of nutrition with an animal-based protein mix, Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia
Protein Quality to Support Increased Muscle Protein Synthesis
The age-related decline in muscle mass and strength is collectively referred to as sarcopenia. Canadian recommended daily allowance (RDA) for protein intake (0.8 g/kg/d), however, many expert groups have advocated that older…
- Trial name
- NCT04026607
- Testing
- Protein Supplementation
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Time Restricted Feeding
Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Recent research shows that timing of nutritional intake and daily periods of fasting may have important health effects. In humans, limiting daily food intake to a narrow window (typically ~8 hours) can bring about some beneficial…
- Trial name
- NCT05420181
- Testing
- Short 10hr fast, Long 16h fast
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity, Skeletal Muscle
Anti-Inflammatory Milk Matrix
Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction.
- Conditions
- Obesity, Skeletal Muscle, Inflammation
- Trial name
- AIMM (NCT04216004)
- Testing
- Controlled-Feeding Intervention, Non-dairy beverage, Full-fat milk
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Muscle Protein Synthesis
Re-evaluation of the Muscle-full Effect During Continuously Elevated Amino Acid Availability in Healthy Young Males
Muscle tissue consists of proteins. These proteins are built up of a collection of smaller building blocks: amino acids. When protein is consumed, it gets digested and absorbed into the blood.
- Trial name
- Muscle-full (NCT06721026)
- Testing
- Continuous intravenous stable isotope amino acid tracer infusion, Amino acid infusion
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolism, Exercise
The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise
Plant-based proteins contain several amino acids that are essential to signal growth, reconditioning, maintenance and preservation of skeletal muscle mass.
- Conditions
- Metabolism, Exercise, Dietary Supplements
- Trial name
- NCT05020808
- Testing
- NEAA, PPI
- Where
- Ireland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Sarcopenia
Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic…
- Trial name
- NCT01489930
- Testing
- Endurance exercise, Resistance exercise, Control/Combined training
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic