Clinical trials: Muscle Protein Synthesis
Healthy Male Volunteers Over 65
Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults
Occupying ~45-55% of body mass, skeletal muscle is the largest organ of the body and plays a pivotal role in locomotion, structural support and whole-body metabolic health.
- Trial name
- NCT06971822
- Testing
- Protein Supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Menstrual Cycle Phase, Muscle Protein Synthesis
The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis
The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been…
- Trial name
- NCT06268678
- Testing
- Phase of the menstrual cycle
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Tendon Injuries
A Methodology Study to Assess Muscle Damage After Eccentric Exercise
An isolated bout of unaccustomed maximal eccentric exercise is associated with muscle force loss for 2-4 days, mild reversible muscle tenderness, and ultra-structural damage to the muscle fibers, elevation of muscle proteins in…
- Trial name
- NCT02014662
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Muscle Protein Synthesis
The Effect of Mealworm Protein Ingestion on Muscle Protein Synthesis After Running Exercise in Humans
Rationale: Consumption of sufficient dietary protein is fundamental to skeletal muscle mass maintenance and overall health. Conventional animal-based protein sources such as meat, poultry, fish, eggs, and dairy are considered…
- Trial name
- Centurion (NCT05353595)
- Testing
- Insect protein, Running exercise
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mitochondrial Biogenesis
Time-course of Mitochondrial Biogenic Gene and Protein Expression in Exercised Human Skeletal Muscle
This study examines the impact of exercise intensity on the 12-hour time-course of mitochondrial biogenic gene and protein expression in human skeletal muscle.
- Trial name
- NCT03975777
- Testing
- LO, HI
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brendon Gurd, PhD
Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics
Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly
Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge…
- Conditions
- Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics, Sarcopenia
- Trial name
- NCT01640145
- Testing
- Protein, Exercise
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Meal Frequency, Dietary Habits
Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing
Adopting a healthy eating pattern is important for meeting dietary recommendations and weight management. Although less clear, it seems reasonable to assume that the eating patterns we typically follow can also affect our…
- Conditions
- Meal Frequency, Dietary Habits, Muscle Protein Synthesis
- Trial name
- NCT04232254
- Testing
- Animal-based Protein Foods, Skewed Protein Distribution, Plant-based Protein Foods
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Energy Deficit
Effects of Essential Amino Acid-enriched Whey and Carbohydrate Co-ingestion on Protein Kinetics
Previous work conducted by the Investigators demonstrates that an essential amino acid(EAA)-enriched whey protein combination format is an efficient EAA/protein format to support enhanced whole-body protein balance and sustain…
- Trial name
- NCT04621175
- Testing
- EAA+W & Carbohydrate, EAA+W & EAA
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Obesity
Effects of Short-term Energy Deficit on Muscle Protein Turnover
Weight loss through energy restriction results in the loss of both fat and muscle mass. Muscle mass is important for mobility, strength, glucose control and energy expenditure, and therefore the retention of muscle mass during…
- Trial name
- NCT02406040
- Testing
- Energy Restriction
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Protein Synthesis
Re-evaluation of the Muscle-full Effect During Continuously Elevated Amino Acid Availability in Healthy Young Males
Muscle tissue consists of proteins. These proteins are built up of a collection of smaller building blocks: amino acids. When protein is consumed, it gets digested and absorbed into the blood.
- Trial name
- Muscle-full (NCT06721026)
- Testing
- Continuous intravenous stable isotope amino acid tracer infusion, Amino acid infusion
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight and Obesity
GRK-Biased Activation Via β2-Adrenergic Receptors in Human Skeletal Muscle
This longitudinal mechanistic physiological study examines biased β2-adrenergic receptor (β2-AR) signaling in human skeletal muscle, with emphasis on G protein-coupled receptor kinase (GRK)-mediated pathways.
- Trial name
- GAIN (NCT07421024)
- Testing
- ATR-258
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Anabolic Response to Mycoprotein and Micronutrient Ingeston
Mycoprotein and Muscle Protein Synthetic Response
Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues.
- Trial name
- PIMP (NCT04084652)
- Testing
- Mycoprotein ingestion
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia
Modulation of Muscle Protein Synthesis With Diet and Exercise in Old Aged Women
In this study will measure differences in how muscle responds to both exercise and protein supplements in healthy women aged 60-69.
- Trial name
- NCT02053441
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Plantar Fasciitis
Plantar Heel Pain: Multisegment Foot Motion and Muscle Function, FFI Translation, and Evaluation of Treatments
Plantar fasciitis (PF) is a prevalent musculoskeletal condition of plantar heel pain (PHP) that leads to pain, functional limitations, and reduced quality of life, especially among active adults aged 25 to 65.
- Trial name
- NCT03161314
- Testing
- Strengthening exercises, Stretching exercises
- Where
- 2 sites in Thailand
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Older Adults, Muscle Protein Synthetic Response to Protein
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
As the loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the primary outcome of the trial is to…
- Conditions
- Older Adults, Muscle Protein Synthetic Response to Protein, Reduced Physical Activity
- Trial name
- NCT02347137
- Testing
- step-reduction, step-reduction plus resistance exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Assessing the Impact of "Super-whey" vs. Isonitrogenous Whey on Muscle Protein Synthesis
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- ARLA-WHEY (NCT05701202)
- Testing
- Super-Whey protein, Isonitrogenous whey protein
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Protein Synthesis, Sarcopenia
The Anabolic Properties of Fortified Plant-based Protein in Older People
Rationale: Consumption of sufficient dietary protein is fundamental to skeletal muscle mass maintenance and overall health. Conventional animal-based protein sources such as meat, poultry, fish, eggs, and dairy are considered…
- Trial name
- Strongplant (NCT05711095)
- Testing
- Fortified plant-based protein blend, Plant-based protein blend, Whey protein
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Effect of Nutrition on Muscle Protein Synthesis
The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities.
- Trial name
- NCT00604929
- Testing
- carbohydrate and protein
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Effect of Whey Protein Hydrolysate on Human Muscle Protein Synthesis
Muscle protein synthesis can be stimulated by ingestion of protein sources, such as whey, casein or soy. Protein supplementation can be useful to restore protein turnover after exercise but also to preserve skeletal muscle mass…
- Trial name
- NCT03313830
- Testing
- Whey Protein Hydrolysate (WPH), Intact Whey Protein (WHEY)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston