Clinical trials: Muscle Protein Synthesis
Menstrual Cycle, Resistance Exercise
Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on Muscle Protein Synthesis
Skeletal muscle size and function is regulated by various factors, including hormones. While we understand the role of male sex hormones (testosterone), we aren't sure how female sex hormones (estrogen and progesterone) influence…
- Conditions
- Menstrual Cycle, Resistance Exercise, Muscle Protein Synthesis, OCP
- Trial name
- NCT05347667
- Testing
- Unilateral Resistance Exercise Leg, Control Leg
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Protein Synthesis, Amino Acid
Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP)
10 young males will be recruited to participate in a randomized double blinded crossover study to investigate the influence of concomitant intake of two different types of carbohydrate with protein hydrolysate on the absorption…
- Trial name
- ICADP (NCT03303729)
- Testing
- Meat Hydrolysate, Cluster Dextrin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Sarcopenia
Technological Processes on Quality of Meat
This project aims to assess the impact of technological processes of meat, as cooking conditions, on amino acid bioavailability and protein metabolism.
- Trial name
- NCT02157805
- Testing
- beef meat
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Meat Protein Supplements, Protein Absorption and Amino Acid Availability
Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef
To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males.
- Conditions
- Meat Protein Supplements, Protein Absorption and Amino Acid Availability, Muscle Protein Synthesis
- Trial name
- NCT02732353
- Testing
- Minced beef, Hydrolyzed beef
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kasper Dideriksen
Critical Illness, Muscle Protein Synthetic Response to Protein
Enhanced Protein Intake to Support Muscle Protein Synthesis in ICU
Rationale - Critically ill patients often experience severe skeletal muscle wasting due to an imbalance between muscle protein synthesis (MPS) and degradation, contributing to long-term impairments such as ICU-acquired weakness…
- Trial name
- IPA-IC (NCT06714240)
- Testing
- Nutritionally complete Tube Feed with standard protein levels, Nutritionally complete Tube Feed with higher protein levels
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Maastricht University Medical Center
Healthy
Effect of Amino Acid on Muscle Damage
The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.
- Trial name
- NCT03319147
- Testing
- Active
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sarcopenia
Impact of Carbohydrate Co-ingestion on the Post-prandial Anabolic Response of Protein in Young and Elderly Men
Rationale: Age related muscle loss (sarcopenia) is assumed to be related to the impaired postprandial muscle protein synthetic response to protein and/or amino acid administration in the elderly vs the young.
- Trial name
- PRO-CARB (NCT01576848)
- Testing
- Protein, Protein + carbohydrate
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Resistance Exercise
Skeletal Muscle Protein Synthesis: Traditional and Cluster Sets
Traditionally, when performing resistance exercise, repetitions are performed in a continuous manner resulting in a decrease in velocity, and thus power output.
- Trial name
- NCT04028726
- Testing
- Back-squat exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Muscle Protein Synthesis, Sarcopenia
The Anabolic Properties of Fortified Plant-based Protein in Older People
Rationale: Consumption of sufficient dietary protein is fundamental to skeletal muscle mass maintenance and overall health. Conventional animal-based protein sources such as meat, poultry, fish, eggs, and dairy are considered…
- Trial name
- Strongplant (NCT05711095)
- Testing
- Fortified plant-based protein blend, Plant-based protein blend, Whey protein
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscular Atrophy
Timecourse of Immobilization Experiment
The effect of unilateral lower limb immobilisation over one week on muscle atrophy
- Trial name
- TIME (NCT02984332)
- Testing
- Lower limb immobilisation (leg brace)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Regulation of Muscle Protein Synthesis
Role of Leucine in the Regulation of Human Myofibrillar Protein Synthesis at Rest and Following Resistance Exercise
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01492010
- Testing
- whey protein, whey protein supplemented with leucine, whey protein supplemented with essential amino acids
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Protein Synthetic Response to Protein
The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals
Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become…
- Trial name
- OmniVeg_Diet (NCT07049224)
- Testing
- Meat diet, Plant diet
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hyperglycaemia (Non Diabetic), Prediabetes
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover…
- Trial name
- PORK (NCT06025292)
- Testing
- Lean Pork vs Plant-Based Protein
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Sarcopenia
Postprandial Muscle Protein Synthesis Following Wheat Protein Ingestion in Vivo in Humans
Rationale: The progressive loss of skeletal muscle mass with aging, or sarcopenia, has a major impact on our health care system due to increased morbidity and greater need for hospitalization and/or institutionalization.
- Trial name
- NCT01952639
- Testing
- protein type and amount
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis, Endotoxemia
Whey vs Casein to Combat Post-inflammatory Protein and Muscle Waste in Acute Disease
This study compares three different protein supplements (casein, whey and leucine-enriched whey) and their effect on post-inflammatory muscle waste in a model of acute disease.
- Conditions
- Muscle Protein Synthesis, Endotoxemia, Nutrition, Milk Protein
- Trial name
- NCT03319550
- Testing
- Casein, Whey, Leucine-enriched whey
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Muscle Protein Synthesis
Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age
Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatment.
- Trial name
- NCT06567665
- Testing
- Leucine
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Meal Frequency, Dietary Habits
Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing
Adopting a healthy eating pattern is important for meeting dietary recommendations and weight management. Although less clear, it seems reasonable to assume that the eating patterns we typically follow can also affect our…
- Conditions
- Meal Frequency, Dietary Habits, Muscle Protein Synthesis
- Trial name
- NCT04232254
- Testing
- Animal-based Protein Foods, Skewed Protein Distribution, Plant-based Protein Foods
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Protein Metabolism
Validating IAAO for Muscle Outcomes
Consuming dietary protein stimulates whole-body and muscle protein synthesis, the latter of which is typically measured using invasive primed constant infusions of stable isotopes with concurrent muscle biopsies.
- Trial name
- VIM (NCT07317921)
- Testing
- Protein + Stable Isotope Tracer Beverage
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Muscle Mass, Protein Intake
Distribution of Nutrient Derived Amino Acids
The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.
- Conditions
- Muscle Mass, Protein Intake, Diet Modification, Protein Synthesis
- Trial name
- NCT03870425
- Testing
- Distribution pattern of dietary proteins (minced meat)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital