Clinical trials: Muscle Protein Synthesis
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Healthy
Effect of Whey Protein Hydrolysate on Human Muscle Protein Synthesis
Muscle protein synthesis can be stimulated by ingestion of protein sources, such as whey, casein or soy. Protein supplementation can be useful to restore protein turnover after exercise but also to preserve skeletal muscle mass…
- Trial name
- NCT03313830
- Testing
- Whey Protein Hydrolysate (WPH), Intact Whey Protein (WHEY)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Nutritional Intervention
The Effect of Ingesting a Novel Algae Protein Source on Rested and Exercised Muscle Protein Synthesis Rates in Older Adults.
To assess the rested and postexercise muscle protein synthetic response following the ingestion of a flavourless algae protein source compared with whey protein in older adults.
- Trial name
- CALM (NCT06852547)
- Testing
- protein
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Muscle Loss, Muscle Anabolism
Essential Amino Acids Supplementation and Muscle Protein Synthesis
The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and…
- Trial name
- NCT01366924
- Testing
- Essential Amino Acids, Endurance exercise
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Older Adults, Muscle Protein Synthetic Response to Protein
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
As the loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the primary outcome of the trial is to…
- Conditions
- Older Adults, Muscle Protein Synthetic Response to Protein, Reduced Physical Activity
- Trial name
- NCT02347137
- Testing
- step-reduction, step-reduction plus resistance exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Skeletal Muscle Atrophy
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- PoEMS (NCT05997095)
- Testing
- Neuromuscular electrical stimulation (NMES/0
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Mitochondrial Biogenesis
Time-course of Mitochondrial Biogenic Gene and Protein Expression in Exercised Human Skeletal Muscle
This study examines the impact of exercise intensity on the 12-hour time-course of mitochondrial biogenic gene and protein expression in human skeletal muscle.
- Trial name
- NCT03975777
- Testing
- LO, HI
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brendon Gurd, PhD
Inclusion Body Myositis, Myotonic Dystrophy
The Risk of Falls Index for Patients With Neuromuscular Disorders
The combination of short quantitatively assessing muscular function and balance in combination with short clinical scores, can be a new valid approach to evaluate the patient risk of fall and help to create a quick checkup test…
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Facioscapulohumeral Muscular Dystrophies, Myasthenia Gravis
- Trial name
- NCT05890833
- Testing
- The risk of falls
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- LMU Klinikum
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Sarcopenia
Protein Supplementation to Promote Muscle Protein Anabolism in Frail Elderly People
The present study is designed to investigate whether timed protein supplementation will increase skeletal muscle mass in the frail elderly population.
- Trial name
- ProMuscle (NCT01109628)
- Testing
- Protein drink
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Wageningen University
Fibromyalgia, Heathy Volunteers
Traduction and Validation of the Central Sentitization Inventory Into French
The study will include a translation of the Central Sensisization Inventory into French and a cultural validation of the French version of the questionnaire (Reliability, discrimination and comparison with other questionnaires).
- Trial name
- NCT02270775
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Effect of Food
Nutrient and Hormonal Profile and Muscle Protein Synthesis Response to Consuming Chicken
The study aims to evaluate if there is a difference between eating conventionally raised or organic chicken. The investigators will measure and compare the nutrient and hormone levels in the participant's blood and the muscle…
- Trial name
- NCT06489886
- Testing
- Conventional Chicken, Regenerative Chicken
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cirrhosis
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.
- Trial name
- NCT03225677
- Testing
- blood draw and muscle biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Dietary Protein, Female Protein Metabolism
A 'Non-Invasive' Breath Test to Determine Anabolic Sensitivity in Females
The maintenance of lean body mass, especially skeletal muscle, is vital for optimal health and performance across the lifespan. The protein component of lean body mass is in a constant state of turnover, involving the…
- Conditions
- Dietary Protein, Female Protein Metabolism, Anabolic Sensitivity, Resistance Exercise
- Trial name
- FBT (NCT05422300)
- Testing
- Fed, Ex-Fed
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Stroke
Exercise For Sub-acute Stroke Patients in Jamaica
Chronic hemiparetic stroke is associated changes in body composition, skeletal muscle and cardiometabolic health; specific changes include paretic limb muscular atrophy, increased intramuscular fat deposition, elevated prevalence…
- Trial name
- JAMMS (NCT01392391)
- Testing
- Task Oriented Exercise Training, Stroke Care "Get with the Guidelines"
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 150 people
- Sponsor
- Baltimore VA Medical Center
Obesity
Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals
It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass.
- Trial name
- NCT01530646
- Testing
- Weight loss, Soy, Whey
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
COPD
Casein Protein and Leucine Supplementation in Chronic Obstructive Pulmonary Disease (COPD)
Weight loss commonly occurs in patients with COPD, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01734473
- Testing
- Hydrolyzed casein protein, Hydrolyzed casein protein + carbohydrates, Hydrolyzed casein protein + leucine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Protein, Diet
A Meal-based Comparison of Protein Quality, Complementary Proteins and Muscle Anabolism
To highlight the importance of protein quality rather than the total protein content of a meal, the investigators will demonstrate that unlike high quality proteins, a single meal containing 30 g of an incomplete protein source…
- Conditions
- Protein, Diet, Skeletal Muscle
- Trial name
- MAPP (NCT03816579)
- Testing
- PRO-A, PRO-B, PRO-C
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston