Clinical trials: Muscle Relaxants
Anesthesia, General
Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly
Laryngeal mask airway (LMA) is currently the most widely used supraglottic airway device with advantages of simple and fast placement, reduced anesthesia drug use, more stable hemodynamics, and less throat discomfort after…
- Trial name
- LMA (NCT05310110)
- Testing
- 10% lidocaine spray, Cisatracurium, Propofol
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chronic Kidney Disease
Measuring Sleep Quality With Puki in Hemodialysis Patients Performing Progressive Muscle Relaxant Exercises
Chronic kidney disease is a chronic disease that negatively affects the quality of life of individuals, physically, socially and psychologically.
- Trial name
- NCT05604833
- Testing
- Progressive Muscle Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Muscle Relaxation, Sex
Sex-related Differences in the Response to the Muscle Relaxant Drug Mivacurium
Muscle relaxants are drugs providing muscle relaxation during surgical treatment. Previous studies have shown that males and females respond differently to this kind of drug.
- Trial name
- NCT01906528
- Testing
- Mivacurium
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Unilateral Knee Arthroplasty
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces…
- Trial name
- IVAM (NCT02449369)
- Testing
- Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Postoperative Pain
Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses
Intubation is a procedure that requires well relaxed muscles while general anesthesia is performed. In order to get adequate muscle relaxation, remifentanil, sevoflurane or both agents in combination have been reported as they…
- Trial name
- NCT02440204
- Testing
- Intubation, Remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Severance Hospital
Intubation; Difficult or Failed, Muscle Relaxation
Use of Muscle Relaxants in Parotidectomy Operation With Neuromonitoring
Neuromuscular blockers provide muscle relaxation by blocking the electrical conduction to motor nerves and facilitate endotracheal tube placement while relaxing the whole body for surgical comfort during general anesthesia.
- Conditions
- Intubation; Difficult or Failed, Muscle Relaxation, Anesthesia Intubation Complication, Airway Complication of Anesthesia
- Trial name
- NCT05432570
- Testing
- Group A - Muscle Relaxants Used, Group B - No Muscle Relaxants
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Entropy Device and How Will Muscle Relaxants Affect it
Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia
Many studies have explored the effects of inhalation anesthetics, intravenous anesthetics, and muscle relaxants on spectral entropy, but most did not monitor the degree of neuromuscular block.
- Trial name
- NCT05097508
- Testing
- Atracurium Besylate, Rocuronium Bromide, Entropy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Muscle Relaxant
Comparison of Intubating Condition of the Mcgrath Videolaryngoscope With and Without Muscle Relaxant
The objective of this study was to evaluate intubating condition using the McGrath® VL Series 5, with and without muscle relaxant
- Trial name
- NCT02575716
- Testing
- Videolaryngoscope
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Muscle Relaxants
The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy
This study aimed to compare the effect of no muscle relaxants and reduced-dose rocuronium on the anesthetic induction and emergence with fentanyl in children undergoing adenotonsillectomy.
- Trial name
- NCT02467595
- Testing
- Rocuronium bromide 0.15 mg kg-1, Rocuronium bromide 0.3 mg kg-1, Fentanyl
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Muscle Relaxants
Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle relaxants are medications used during surgery to facilitate surgical access. The effect of the muscle relaxant medications is measured by stimulation a motor nerve and measuring the force of the resultant muscle…
- Trial name
- NCT02425449
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Pain, Postoperative
Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty
This is a prospective, cluster-randomized, two-arm, comparative study aimed at determining whether addition of tizanidine ( an oral muscle relaxant) to a multimodal pain regimen following primary TKA reduces opioid consumption.
- Trial name
- NCT04574791
- Testing
- TiZANidine 2 MG Oral Capsule
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Anesthesia Intubation Complication
Fentanyl and Propofol for Tracheal Intubation During Sevoflurane Induction Without Muscle Relaxants in Children
Several methods have been proposed to improve intubating conditions and minimize sevoflurane induction time during sevoflurane induction in children.
- Trial name
- NCT02442128
- Testing
- propofol /Fentanyl, Fentanyl / propofol
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Saud University
Muscle Relaxant, General Anesthesia
Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose
This study aimed to evaluate the effect of Neostigmine partial dose towards neuromuscular blockade of rocuronium
- Trial name
- NCT03058263
- Testing
- Dose of Neostigmine
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Anesthesia, Bronchoscopy
Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for Bronchoscopy
The goal of this clinical trial is to evaluate whether mivacurium chloride and succinylcholine can provide effective and safe muscle relaxation in adult patients aged 18-60 years undergoing bronchoscopy who require muscle…
- Conditions
- Anesthesia, Bronchoscopy, Muscle Relaxants
- Trial name
- NCT06709066
- Testing
- mivacurium chloride, succinylcholine
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peng Liang
TOF, Sex
Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System
To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.
- Trial name
- NCT02364934
- Testing
- Propofol, Sevoflurane
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital