Clinical trials: Muscle Relaxants
Anesthesia, Bronchoscopy
Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for Bronchoscopy
The goal of this clinical trial is to evaluate whether mivacurium chloride and succinylcholine can provide effective and safe muscle relaxation in adult patients aged 18-60 years undergoing bronchoscopy who require muscle…
- Conditions
- Anesthesia, Bronchoscopy, Muscle Relaxants
- Trial name
- NCT06709066
- Testing
- mivacurium chloride, succinylcholine
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peng Liang
Muscle Relaxation
Interindividual Variability in Duration of Action of Rocuronium in Pediatric Patients
Muscle relaxants represent an important part of general anesthesia in adult and pediatric patients. Their role is to facilitate intubation and enable some surgical interventions.
- Trial name
- DurAct (NCT05529420)
- Testing
- measurement of the depth of neuromuscular blockade
- Where
- Czechia
- Volunteers
- 107 people
- Sponsor
- Brno University Hospital
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Chronic Kidney Disease
Measuring Sleep Quality With Puki in Hemodialysis Patients Performing Progressive Muscle Relaxant Exercises
Chronic kidney disease is a chronic disease that negatively affects the quality of life of individuals, physically, socially and psychologically.
- Trial name
- NCT05604833
- Testing
- Progressive Muscle Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Anesthesia Intubation Complication
Fentanyl and Propofol for Tracheal Intubation During Sevoflurane Induction Without Muscle Relaxants in Children
Several methods have been proposed to improve intubating conditions and minimize sevoflurane induction time during sevoflurane induction in children.
- Trial name
- NCT02442128
- Testing
- propofol /Fentanyl, Fentanyl / propofol
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Saud University
Muscle Relaxant
Small Doses Muscle Relaxant in General Anesthesia
This study will be held to assess the effect of minimal dose muscle relaxant on postoperative pulmonary function. The time to extubation in minutes will be the primary outcome as a clinical indicator of the return of muscle…
- Trial name
- relaxant (NCT04344262)
- Testing
- Atracurium Besylate regular dose, Atracurium Besylate minial dose
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Neuromuscular Blockade
Myorelaxation Practice in Paediatric Anesthesia
In retrospective data search the investigators will identified the percentage of patients with muscle relaxants administered during perioperative period.
- Trial name
- PAMPE (NCT03086915)
- Testing
- Neuromuscular Blocking Agent
- Where
- Czechia
- Volunteers
- 1,650 people
- Sponsor
- Brno University Hospital
Nondepolarising Muscle Relaxants
Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)
The aim of this research was to determine the influence of ulinastatin on nondepolarising muscle relaxants Rocuronium and Cisatracurium.
- Trial name
- NCT05716256
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia
Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia
Myorelaxation is generally used as a part of general anesthesia for interventional rigid bronchoscopy. Succinylcholine is most often used because its short duration of action but rocuronium can be used since sugammadex permits a…
- Trial name
- Broncho-SR (NCT01579864)
- Testing
- succinylcholine, rocuronium
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Hopital Foch
Sugammadex
Effectiveness of Sugammadex on Muscle Relaxant Reversal in Preterm Neonates
The primary aim of the work is to compare the efficacy of Sugammadex and neostigmine in reversing rocuronium-induced muscle relaxation to reach complete recovery of neuromuscular block (TOF ratio≥ 0.9) in preterm neonates.
- Trial name
- NCT04566796
- Testing
- Sugammadex, Neostigmine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Laryngeal Mask Airway
Effect of Muscle Relaxants on Postoperative Sore Throat in Video Laryngeal Mask Airway(LMA) Use
Video laryngeal masks (VLMAs) are increasingly used as a minimally invasive alternative in airway management. The use of neuromuscular blocking agents can affect VLMA placement and airway physiology.
- Trial name
- NCT07838051
- Testing
- using rocuronium before vide laryngeal mask airway
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun University
Acute Low Back Pain
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Low back pain causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In a general low back pain (LBP) population, prognosis is poor.
- Trial name
- NCT01587274
- Testing
- Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Montefiore Medical Center
Pain, Disability
Do Benzodiazepines Improve the Outcome of Mechanical Physiotherapy for Lumbar Disk Prolapse
Sixty patients were randomized to receive either placebo or diazepam in addition to mechanical physiotherapy and analgesics for the first 7 days of conservative treatment of clinically and radiologically confirmed lumbar disk…
- Conditions
- Pain, Disability, Paresis
- Trial name
- NCT00533286
- Testing
- benzodiacepine
- Sponsor
- University Hospital Tuebingen
Neuromuscular Block
Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
The magnesium sulfate and lidocaine have been increasingly used alone or in combination during anesthesia procedure to meet various objectives, such as reduction of pain, use of smaller anesthetic doses and stabilization of…
- Trial name
- NCT02483611
- Testing
- Magnesium Sulfate, Lidocaine, Isotonic Solution
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
TOF, Sex
Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System
To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.
- Trial name
- NCT02364934
- Testing
- Propofol, Sevoflurane
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Hypersalivation, Prevention of Drooling
Efficacy of Intravenous Glyco-P® in Patients Undergoing Procedure That Require Anesthesia Service
This observational study was designed to prove clinical efficacy of the well known "glycopyrrolate" which is considered an orphan drug in Thailand.
- Conditions
- Hypersalivation, Prevention of Drooling, Bradycardia, Reversal of Muscle Relaxants
- Trial name
- NCT02102542
- Where
- Thailand
- Volunteers
- 65 people
- Sponsor
- Mahidol University
Postcardiac Arrest Therapeutic Hypothermia
When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?
After successful resuscitation from cardiac arrest, cooling the whole body is a well established treatment that improves the chances of the brain recovering.
- Trial name
- NCT02033733
- Testing
- Cisatracurium infusion, Cisatracurium prn bolus
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
ARDS
Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients
The use of neuromuscular blocking agents (NMBA) in ARDS patients has not been extensively investigated. The aim of the study is to show a reduction of the mortality rate of ARDS patients.
- Trial name
- NCT00299650
- Testing
- cisatracurium, Cisatracurium besilate
- Where
- 20 sites in France
- Volunteers
- 340 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Muscle Relaxation, Sex
Sex-related Differences in the Response to the Muscle Relaxant Drug Mivacurium
Muscle relaxants are drugs providing muscle relaxation during surgical treatment. Previous studies have shown that males and females respond differently to this kind of drug.
- Trial name
- NCT01906528
- Testing
- Mivacurium
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bradycardia, Neostigmine Adverse Reaction
0.6 vs. 1.2 mg Atropine Together With Neostigmine 2.5 mg on Heart Rate in Patient Receiving Muscle Relaxant
Balanced general anesthesia with neuromuscular blocking agents has been widely used for surgery.. At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects…
- Conditions
- Bradycardia, Neostigmine Adverse Reaction, Adverse Reaction to Belladonna or Atropine
- Trial name
- NCT02186132
- Testing
- Atropine 0.6 mg, Atropine 1.2 mg
- Volunteers
- 40 people
- Sponsor
- Mahidol University