Clinical trials: Muscle Synthesis
Rehabilitative Nutrition for Muscle Recovery From ACL Reconstruction
Protein in Feeding Strategies to Accelerate Muscle Recovery From ACL Reconstruction
Musculoskeletal injury, particularly injuries requiring surgical repair, induce significant muscle atrophy, resulting in diminished physical function.
- Trial name
- NCT03492021
- Testing
- Diet Intervention_AP-CPT, Diet Intervention_PP-PPT
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscular Atrophy
Timecourse of Immobilization Experiment
The effect of unilateral lower limb immobilisation over one week on muscle atrophy
- Trial name
- TIME (NCT02984332)
- Testing
- Lower limb immobilisation (leg brace)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Glycogen Depletion
Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles
The aim of this experiment is to investigate if intake of stevioside in addition to a carbohydrate-containing composition after work related depletion of muscle glycogen will increase the rate of glycogen re-synthesis as compared…
- Trial name
- steviagly (NCT02146183)
- Testing
- Carbohydrate steviol glycosides
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Per Bendix Jeppesen
Sarcopenia
Impact of Carbohydrate Co-ingestion on the Post-prandial Anabolic Response of Protein in Young and Elderly Men
Rationale: Age related muscle loss (sarcopenia) is assumed to be related to the impaired postprandial muscle protein synthetic response to protein and/or amino acid administration in the elderly vs the young.
- Trial name
- PRO-CARB (NCT01576848)
- Testing
- Protein, Protein + carbohydrate
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Protein Metabolism
Validating IAAO for Muscle Outcomes
Consuming dietary protein stimulates whole-body and muscle protein synthesis, the latter of which is typically measured using invasive primed constant infusions of stable isotopes with concurrent muscle biopsies.
- Trial name
- VIM (NCT07317921)
- Testing
- Protein + Stable Isotope Tracer Beverage
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Resistance Training, Muscle Damage
Protein Supplementation and Recovery of Muscle Function
The focus is performance nutrition. Resistance exercise can induce low level muscle damage in conjunction with impaired contractile function.
- Trial name
- NCT03297151
- Testing
- CONTROL, Whey Protein Concentrate, Whey Protein Hydrolysate
- Where
- Ireland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Insulin Sensitivity
mTOR as Mediator of Insulin Sensitivity Study
The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise.
- Trial name
- NCT05233722
- Testing
- Exercise, Insulin infusion, Rapamycin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Muscle Atrophy
Beta-lactoglobulin, Immobilisation and Muscle Protein Synthesis
The objectives of this study are to: 1. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living…
- Trial name
- NCT05496452
- Testing
- Beta-lactoglobulin, Carbohydrate
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- King's College London
No Condition, Healthy Individuals
Protein Intake Distribution to Support Muscle Anabolism in Healthy Young Adults
The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.
- Trial name
- NCT07245199
- Testing
- protein intake
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypertrophy
D2O Dosing Strategies to Assess Muscle Protein Synthesis
Skeletal muscle mass is regulated by the balance of muscle protein synthesis (MPS) and muscle protein breakdown (MPB). MPS is sensitive to exogenous stimuli, particularly exercise and protein ingestion.
- Trial name
- D2O-MPS (NCT04256343)
- Testing
- Deuterium Oxide (D2O) Dose
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Determining the Muscle Anabolic Properties of Phosphatidic Acid.
Ageing is characterized by a loss of muscle mass that is detrimental for physical function and metabolic health and increases the risk of mortality.
- Trial name
- PA-AGE (NCT03446924)
- Testing
- Phosphatidic Acid, Rice flour
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham