Clinical trials: Muscle Synthesis
Protein Metabolism
Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides
Skeletal muscle quality is an important determinant of exercise performance and overall health. It is vital for not just movement, but also metabolizing nutrients.
- Trial name
- NCT03952884
- Testing
- Resistance Exercise, No Resistance Exercise, Leucine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Muscle Anabolism
A Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (MK-0000-064)
This is a study to evaluate the use of fractional synthetic rate as an early biomarker of muscle anabolism (muscle build-up).
- Trial name
- NCT00816712
- Testing
- Comparator: Testosterone 300 mg, intramuscular injection, Comparator: Testosterone 100 mg, Intramuscular injection
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Omega-3 Fatty Acids and Muscle Protein Synthesis
The purpose of this study is to determine whether omega-3 fatty acid supplementation influences muscle protein synthesis rates in young and older adults.
- Trial name
- NCT00794079
- Testing
- omega-3 fatty acids, corn oil
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Muscle, Skeletal, High-Intensity Interval Training
Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT
High intensity interval training (HIIT) has recently emerged as a time efficient alternative to conventional endurance exercise, conferring similar or superior benefits in terms of metabolic and performance adaptations in both…
- Conditions
- Muscle, Skeletal, High-Intensity Interval Training, Exercise
- Trial name
- NCT03570424
- Testing
- Nutrient support to HIIT
- Where
- Ireland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Healthy
Effect of Amino Acid on Muscle Damage
The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.
- Trial name
- NCT03319147
- Testing
- Active
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
25-hydroxyvitamin D Concentration (Vitamin D Status)
D-Light Intervention
Vitamin D insufficiency has become a global concern, with low vitamin D status associated with bone disorders, cardiovascular disease and certain cancers.
- Trial name
- D-Light (NCT02495584)
- Testing
- Fortified milk (10µg vitamin D3), 10µg vitamin D3 supplement
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Nutritional Intervention
The Effect of Ingesting a Novel Algae Protein Source on Rested and Exercised Muscle Protein Synthesis Rates in Older Adults.
To assess the rested and postexercise muscle protein synthetic response following the ingestion of a flavourless algae protein source compared with whey protein in older adults.
- Trial name
- CALM (NCT06852547)
- Testing
- protein
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy
The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing
Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year.
- Trial name
- NCT02152839
- Testing
- Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic…
- Trial name
- NCT01489930
- Testing
- Endurance exercise, Resistance exercise, Control/Combined training
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Vitamin D Supplementation in Healthy Adults in Prolonged Endurance Exercise
The purpose of this study is to investigate the effects of vitamin D supplementation on biochemistry response and skeletal muscle synthesis in prolonged endurance exercise.
- Trial name
- NCT05781620
- Testing
- Vitamin D, Medium-chain triglycerides
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Regulation of Muscle Protein Synthesis
Role of Leucine in the Regulation of Human Myofibrillar Protein Synthesis at Rest and Following Resistance Exercise
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01492010
- Testing
- whey protein, whey protein supplemented with leucine, whey protein supplemented with essential amino acids
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Protein Quality to Support Increased Muscle Protein Synthesis
The age-related decline in muscle mass and strength is collectively referred to as sarcopenia. Canadian recommended daily allowance (RDA) for protein intake (0.8 g/kg/d), however, many expert groups have advocated that older…
- Trial name
- NCT04026607
- Testing
- Protein Supplementation
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Meat Protein Supplements, Protein Absorption and Amino Acid Availability
Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef
To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males.
- Conditions
- Meat Protein Supplements, Protein Absorption and Amino Acid Availability, Muscle Protein Synthesis
- Trial name
- NCT02732353
- Testing
- Minced beef, Hydrolyzed beef
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kasper Dideriksen
Protein, Diet
A Meal-based Comparison of Protein Quality, Complementary Proteins and Muscle Anabolism
To highlight the importance of protein quality rather than the total protein content of a meal, the investigators will demonstrate that unlike high quality proteins, a single meal containing 30 g of an incomplete protein source…
- Conditions
- Protein, Diet, Skeletal Muscle
- Trial name
- MAPP (NCT03816579)
- Testing
- PRO-A, PRO-B, PRO-C
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Healthy, Skeletal Muscle Atrophy
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse
Skeletal muscle plays a critical role in supporting human health. Beyond its role in providing the force to move, skeletal muscle accounts for a large proportion of metabolic rate, glucose disposal, and amino acid storage.
- Conditions
- Healthy, Skeletal Muscle Atrophy, Skeletal Muscle Hypertrophy
- Trial name
- NCT06350591
- Testing
- Immobilization, Resistance training
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Queen's University
Muscle Protein Synthesis, Amino Acid
Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP)
10 young males will be recruited to participate in a randomized double blinded crossover study to investigate the influence of concomitant intake of two different types of carbohydrate with protein hydrolysate on the absorption…
- Trial name
- ICADP (NCT03303729)
- Testing
- Meat Hydrolysate, Cluster Dextrin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Muscle Loss, Muscle Anabolism
Essential Amino Acids Supplementation and Muscle Protein Synthesis
The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and…
- Trial name
- NCT01366924
- Testing
- Essential Amino Acids, Endurance exercise
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Aging, Sarcopenia
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.
- Trial name
- NCT04015479
- Testing
- Peanut Protein Powder, Full body resistance training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Auburn University