Clinical trials: Muscle Synthesis
Menstrual Cycle Phase, Muscle Protein Synthesis
The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis
The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been…
- Trial name
- NCT06268678
- Testing
- Phase of the menstrual cycle
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Soreness
Vegan Whey Protein for Muscle Anabolism and Post-exercise Recovery
This study will be a randomised, double-blind trial where participants will be randomly assigned to consume either a i) vegan whey protein; ii) a whey protein; or iii) a non-protein carbohydrate control supplement for 3 days…
- Trial name
- NCT07119749
- Testing
- Stable isotope tracer consumption, DXA scan, Controlled diet
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Dairy Products, Muscle Protein Synthesis
The Effect of Whole Milk to Improve Muscle Health in Older Women
Muscle and strength begin to noticeably decline around 50 years of age, increasing an individual's risk for disease and disability.
- Conditions
- Dairy Products, Muscle Protein Synthesis, Aging, Physical Activity
- Trial name
- NCT04981652
- Testing
- Whole Milk, Skim Milk, Almond Beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Volunteers, Female
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM®) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
- Conditions
- Healthy Volunteers, Female, Progesterone, Premenopausal
- Trial name
- MP4 MPS (NCT07173361)
- Testing
- Micronized progesterone (oral capsules)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia, Dietary Protein
Dietary Protein Quality for Skeletal Muscle Anabolism in Older Adults
Dietary proteins potently augment muscle protein synthesis. Because of poorer anabolic sensitivity with ageing, studies and guidelines recommend higher dietary protein intake for older adults.
- Conditions
- Sarcopenia, Dietary Protein, Resistance Exercise
- Trial name
- NCT05574205
- Testing
- Resistance Exercise, Protein supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Aging, Sarcopenia
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.
- Trial name
- NCT04015479
- Testing
- Peanut Protein Powder, Full body resistance training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Auburn University
Nutritional Intervention
The Effect of Ingesting a Novel Algae Protein Source on Rested and Exercised Muscle Protein Synthesis Rates in Older Adults.
To assess the rested and postexercise muscle protein synthetic response following the ingestion of a flavourless algae protein source compared with whey protein in older adults.
- Trial name
- CALM (NCT06852547)
- Testing
- protein
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Effect of Food
Nutrient Profile and Muscle Protein Synthesis in Response to Corn Bread Made From Refined Versus Whole Grain Maize Flour
The purpose of the study is to quantify and compare the serum nutrient and hormonal profile, and muscle protein synthesis rates, in response to consuming isonitrogenous amounts of a traditional East African meal, mung bean stew…
- Trial name
- PRO-CORN (NCT06662214)
- Testing
- Refined maize flour, Whole grain flour
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Muscle Mass, Protein Intake
Distribution of Nutrient Derived Amino Acids
The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.
- Conditions
- Muscle Mass, Protein Intake, Diet Modification, Protein Synthesis
- Trial name
- NCT03870425
- Testing
- Distribution pattern of dietary proteins (minced meat)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Older Adults, Muscle Protein Synthetic Response to Protein
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
As the loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the primary outcome of the trial is to…
- Conditions
- Older Adults, Muscle Protein Synthetic Response to Protein, Reduced Physical Activity
- Trial name
- NCT02347137
- Testing
- step-reduction, step-reduction plus resistance exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
Using stable isotope methodology, investigators will determine the postabsorptive and postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: <30 kg/m2) immediately after an acute bout of resistance…
- Trial name
- NCT02918981
- Testing
- Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy Males
The Importance of Non-essential Amino Acids for Maintaining Skeletal Muscle Protein Synthesis Rates in Healthy Young Men
Background: Protein intake is important for maintaining skeletal muscle mass. These proteins consist of a collection of small building blocks which are called amino acids.
- Trial name
- NEAA (NCT06687343)
- Testing
- EAA Supplement, NEAA Supplement, Maltodextrin Supplement
- Where
- Netherlands
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Inflammaging, Sarcopenia
Inflammaging and Muscle Protein Metabolism
The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments.
- Trial name
- NCT03308747
- Testing
- Instantized Whey Protein Isolate
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Type 2 Diabetes
"Effect of High Fat and High Glycemic Diets
The investigators will determine whether people with high muscle mitochondrial capacity produce higher amount of reactive oxygen species (ROS) on consuming high fat /high glycemic diet and thus exhibit elevated cellular oxidative…
- Trial name
- NCT01494935
- Testing
- High Glycemic Diet, Control diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Older Adults Without Any Specific Clinical Condition
Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults
Healthy older adults and those who have acute and chronic conditions suffer from reduced protein intake and are at risk of developing both chronic and acute sarcopenia.
- Trial name
- NCT07754760
- Testing
- Essential amino acid supplement
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Muscle Protein Synthesis
The Effect of Mealworm Protein Ingestion on Muscle Protein Synthesis After Running Exercise in Humans
Rationale: Consumption of sufficient dietary protein is fundamental to skeletal muscle mass maintenance and overall health. Conventional animal-based protein sources such as meat, poultry, fish, eggs, and dairy are considered…
- Trial name
- Centurion (NCT05353595)
- Testing
- Insect protein, Running exercise
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
The Effects Potato Protein on Rates of Myofibrillar Muscle Protein Synthesis in Young Women
This study will investigate the effects of potato protein on muscle protein synthesis over a short-term (a few hours after eating) and longer term (after two weeks of unilateral resistance exercise).
- Trial name
- APRE (NCT04302038)
- Testing
- Protein
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Skeletal Muscle, Extracellular Matrix
Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men
The purpose of this study is to assess which amino acids are affecting acute muscle collagen synthesis in response to supplementation and exercise.
- Conditions
- Skeletal Muscle, Extracellular Matrix, Amino Acids Metabolism, Exercise
- Trial name
- PECS (NCT04596553)
- Testing
- Essential Amino Acid, Collagen Peptide
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Muscle Protein Synthesis
Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women
This study investigates whether a protein-nutrition beverage can increase muscle protein synthesis to a similar magnitude as a control beverage.
- Trial name
- NCT02282566
- Testing
- Protein-nutrition beverage
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy
Effect of Whey Protein Hydrolysate on Human Muscle Protein Synthesis
Muscle protein synthesis can be stimulated by ingestion of protein sources, such as whey, casein or soy. Protein supplementation can be useful to restore protein turnover after exercise but also to preserve skeletal muscle mass…
- Trial name
- NCT03313830
- Testing
- Whey Protein Hydrolysate (WPH), Intact Whey Protein (WHEY)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston