Clinical trials: Muscle Wasting
Spinal Muscular Atrophy Type 3, Mitochondrial Myopathy
Oxidative Capacity and Exercise Tolerance in Ambulatory SMA
This proposal will focus on (1) estimating oxidative capacity of specific muscle groups during exercise using near infrared spectroscopy and (2) describing body composition to better understand exercise capacity and mitochondrial…
- Trial name
- NCT02895789
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sarcopenia
Auto-regulated Resistance-training for Older Adults
This research study is comparing the effect of traditional standardized, subjective auto-regulated, and objective auto-regulated resistance training on physiological adaptations and performance measures in adults aged 50 years or…
- Trial name
- NCT05580913
- Testing
- Resistance training
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Spinal Muscular Atrophy
Motor Unit Number Estimation (MUNE) in Adults With Spinal Muscular Atrophy (SMA)
The primary objective of this research protocol is to study and follow the course of motor neuron loss in individuals with spinal muscular atrophy (SMA) using the electrophysiological technique of motor unit number estimation…
- Trial name
- NCT04139343
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Aging, Frailty
A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle Health in Older Adults
This study is a randomized controlled trial where participants would be randomly assigned to one of 2 groups. One group would receive Whole body vibration therapy and usual care and the other group only usual care.
- Conditions
- Aging, Frailty, Sarcopenia, Muscle Strength
- Trial name
- NCT07205133
- Testing
- Whole Body Vibration Training, Otago Exercise
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Sarcopenia, Aging
The Study of Sarcopenia and Aging Biomarkers by the Metabolomics
With the rapid growth of the global elderly population, the studies of the biomarkers of the sarcopenia and aging are under investigation in different ways.
- Trial name
- NCT03121326
- Testing
- blood and urine sampling
- Where
- Taiwan
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Frailty, Sarcopenia
FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
This study is looking at whether older people could benefit from an online monitoring platform to support their individual ambitions to maintain or improve functional ability.
- Conditions
- Frailty, Sarcopenia, Aging
- Trial name
- FACET (NCT03707145)
- Testing
- Consultation, Online Support, Empowered
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Sarcopenia
MRI-Based Paraspinal Fatty Degeneration and Its Association With BMD and Sarcopenia
This cross-sectional study aims to investigate the relationship between MRI-based paraspinal muscle fatty degeneration, bone mineral density (BMD), and sarcopenia parameters in postmenopausal women.
- Trial name
- NCT07238777
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beylikduzu State Hospital
Sarcopenia
A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
- Trial name
- NCT05869526
- Testing
- Fish oil, Kril oil, Vegetable oil
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Sarcopenia, Chronic Lung Disease
Feasibility of Proteomics in Chronic Lung Disease With Sarcopenia
Sarcopenia, the loss of muscle mass and strength with ageing, is a prevalent condition in older adults, particularly those with chronic lung diseases like COPD and interstitial lung disease.
- Trial name
- NCT06312774
- Testing
- This is observational study
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University College, London
Cognition Disorders in Old Age, Cognitive Function
Impact of Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in Older Adults
The goal of this prospective, single site, interventional randomized control trial is to treat age related health conditions in adults older than 65 years and functional independence.
- Conditions
- Cognition Disorders in Old Age, Cognitive Function, Frailty/Sarcopenia, MCI
- Trial name
- INSPIOR (NCT06135740)
- Testing
- Fitbit wearing, with notification for sleep, activity and nutrition based fitbit data, Routine care
- Where
- Japan
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Tokyo University
Sarcopenia
Effect of Ursolic Acid of Loquat Extract on Function of Muscle
This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults.
- Trial name
- NCT02401113
- Testing
- UA group
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Frailty, Sarcopenia
Study of The Effects of Testosterone in Frail Elderly Men
The study aims to determine the effects of testosterone on muscle function, mobility, activities of daily living and overall quality of life
- Trial name
- NCT00190060
- Testing
- Transdermal testosterone gel (Testogel 1% )
- Where
- United Kingdom
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Muscular Atrophy, Sensitivity Training Groups
Effects of Inspiratory Muscle Training in Elders
Aging causes anatomical and physiological changes in the respiratory system and respiratory muscle strength with decline in its maximum function.
- Conditions
- Muscular Atrophy, Sensitivity Training Groups, Aging
- Trial name
- NCT01791010
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Sarcopenia, Frailty
Oral Nutritional Supplementation With HMB Enhance Muscle Quality in Sarcopenic Surgical Patients
Aims: Clinical frailty severely impacts the physical, functional and physiological reserves necessary for the recovery after surgery.
- Trial name
- HEROS (NCT05344313)
- Testing
- Ensure Plus Advance
- Where
- Singapore
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Sarcopenia, Diabetes Mellitus
Identifying Therapeutic Targets of Accelerated Sarcopenia
The proposed research is designed to identify the mechanisms that can accelerate loss of muscle size, strength and physical function in type 2 diabetes and with hospitalization in older persons.
- Conditions
- Sarcopenia, Diabetes Mellitus, Aging
- Trial name
- NCT03118050
- Testing
- Resistance exercise training, Bed rest, Intensive physical therapy
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Spinal Muscular Atrophy, Neonatal Hyperbilirubinemia
Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform.
In this, here we want to present a new method for analysis variation in gene copy number for patients and carriers of SMA. This is a relative quantitation method and, therefore, relies on the inclusion of one or more internal…
- Conditions
- Spinal Muscular Atrophy, Neonatal Hyperbilirubinemia, Colon Cancer
- Trial name
- NCT00154960
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sarcopenia
The Extremities Rehabilitation Training System for Sarcopenic Hospitalized Aged 80+ Years
Most previous clinical trials that addressed the rehabilitation training system for sarcopenic elderly subjects focused on community-dwelling older adults who were relatively healthy.
- Trial name
- NCT04497480
- Testing
- Motor-Assisted and Active Resistive Upper/Lower Extremities Rehabilitation Training System
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuxiang Liang
Sarcopenia, Possible Sarcopenia
HB05P on Muscle Health
The purpose of this pilot study is to evaluate whether HB05P, a health functional food ingredient containing pasteurized Akkermansia muciniphila HB05, improves muscle strength, and to evaluate its safety.
- Trial name
- NCT07749118
- Testing
- HB05P
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Malnutrition, Frailty
Feasibility of Estimating the Prevalence of Malnutrition, Frailty and Sarcopenia in Older People in UK Biobank, Cross-sectional Study: A Study Protocol
Background: measuring the prevalence of malnutrition, frailty and sarcopenia in same group of older adults is effective in understanding the relation between these conditions.
- Conditions
- Malnutrition, Frailty, Sarcopenia
- Trial name
- NCT04655456
- Where
- United Kingdom
- Volunteers
- 381,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Sarcopenia
Study of Inactivity on Metabolism of Elderly Muscles
Skeletal muscle mass declines with inactivity (casting is a good example) and increases with activity (such as weightlifting). Whether muscle mass increases or decreases, is determined by whether more new proteins within muscle…
- Trial name
- NCT01818609
- Testing
- Step reduction
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University