Clinical trials: Muscular Atrophy
Muscle Atrophy, Myotonia
Electromyostimulation (EMS) of Astronauts in Spaceflight (Easymotion-2)
This is a prospective spaceflight study involving an investigational non-risk device called the EasyMotionSkin for whole body electric muscle (myo) stimulation (WB-EMS) onboard the International Space Station (ISS).
- Conditions
- Muscle Atrophy, Myotonia, Stiffness; Spine, Exercise Overtraining
- Trial name
- Easymotion-2 (NCT06492057)
- Testing
- Electromyostimulation (EMS), Myoton, Electromyography (EMG)
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hip Injuries, Muscular Atrophy
Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players
At this investigation we want to find out whether there is a difference in muscle strength of the internal and external rotation hip muscles between soccer players and non-soccer players caused by typical movement patterns seen…
- Conditions
- Hip Injuries, Muscular Atrophy, Dysfunction
- Trial name
- NCT01821183
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Sarcopenia, Spinal Disease
Spinal Sarcopenia Cohort Study (SarcoSpine)
Sarcopenia on lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there are few studies on the precise concept and diagnostic criteria for spinal sarcopenia.
- Trial name
- SarcoSpine (NCT03962530)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Muscle Loss
Muscle Mass During Space Exploration
The investigators will test the following hypotheses: 1. Bedrest will blunt the anabolic response to a mixed nutrient meal, facilitating a loss of muscle mass and functional capacity that is only partially restored during…
- Trial name
- NCT00968344
- Testing
- Leucine, Alanine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Lower-limb Orthoses, Frailty/Sarcopenia
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses
The overall goal of this project is to develop modular, lower-limb, powered orthoses that fit to user-specific weakened joints and control force/torque in a manner that enhances voluntary motion in broad patient populations.
- Conditions
- Lower-limb Orthoses, Frailty/Sarcopenia, Chronic Overuse Musculoskeletal Injuries
- Trial name
- NCT05240014
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoporosis, Sarcopenia
Bone Microstructure After Gastrectomy Evaluating by Using HR-pQCT
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03398226
- Where
- Japan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nagasaki University
Myotonic Dystrophy 1, DM1
The Spanish National Registry for Myotonic Dystrophy Type 1
Myotonic Dystrophy Type 1 (DM1) is a rare genetic neuromuscular condition that can affect multiple organs and varies widely in how it presents.
- Conditions
- Myotonic Dystrophy 1, DM1, Myotonic Dystrophy Type 1, Myotonic Dystrophy, Congenital
- Trial name
- DM1-Hub (NCT07385443)
- Testing
- Patient Registry
- Where
- 8 sites in Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
Sarcopenia
Modulation of Muscle Protein Synthesis With Diet and Exercise in Old Aged Women
In this study will measure differences in how muscle responds to both exercise and protein supplements in healthy women aged 60-69.
- Trial name
- NCT02053441
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Inflammation, Sarcopenia
The Combined Effects of Resistance Training and Flax Oil Supplementation Upon Inflammation in Older Adults
Loss of muscle mass and functional ability is a major concern for older individuals. Aging is associated with increased inflammation caused by release of hormone-like compounds termed "cytokines" which are involved in muscle…
- Trial name
- NCT00465153
- Testing
- flax oil containing alpha linolenic acid, Resistance exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Old Age
Modulation of Muscle Protein Metabolism by Essential Amino Acids
The investigators plan to explore the ability of amino acids, the building blocks of proteins in our bodies and in the food we eat, to stimulate muscles to grow and stay strong.
- Trial name
- Aj1B (NCT01890369)
- Testing
- 15g Mixed Essential Amino Acids, 3g Leucine, 15g Mixed Essential Amino Acid REFEED
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Age-Related Loss of Skeletal Muscle Mass, Aging
Agility Training for Older Adults to Improve Fall Risk Factors
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as…
- Conditions
- Age-Related Loss of Skeletal Muscle Mass, Aging, Sarcopenia, Cognitive Decline
- Trial name
- AgilE (NCT05727254)
- Testing
- Agility training, Exercise recommendations, Exercise diary
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Oliver Faude
Aging, Muscle Loss
Protein Intake and Step Reduction in Older Adults
Sarcopenia, the loss in muscle mass with age, is associated with several negative health outcomes including cancer, stroke, cardiovascular disease and diabetes.
- Trial name
- DRI (NCT03285737)
- Testing
- Whey, Collagen
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Creatine-Guanidinoacetic Acid Supplementation for Sarcopenia (CREGAAS)
Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target…
- Trial name
- CREGAAS (NCT04652921)
- Testing
- Creatine-guanidinoacetic acid, Inulin
- Where
- Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics
Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly
Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge…
- Conditions
- Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics, Sarcopenia
- Trial name
- NCT01640145
- Testing
- Protein, Exercise
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Muscle Atrophy, Surgery
Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
The loss of muscle mass post-surgery confounds recovery efforts and leads to a delay in patient's ability to return to activities.
- Conditions
- Muscle Atrophy, Surgery, Knee Injuries and Disorders, Complication of Surgical Procedure
- Trial name
- NCT04456530
- Testing
- Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Stone Research Foundation for Sports Medicine and Arthritis
Duchenne Muscular Dystrophy (DMD)
To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20
This study will evaluate the pharmacokinetics plasma profile of 3 treatments: ISO 20, IBU 200 and IBU and ISO combinations (200 +20) given in single dose.
- Trial name
- ISOFEN1 (NCT01478022)
- Testing
- Isosorbide Dinitrate, Ibuprofen, Ibuprofen and Isosorbide Dinitrate combination
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Parent Project, Italy
Sarcopenia
Neuromuscular Electrical Stimulation and Physical Function in Older Adults
The purpose of this placebo controlled clinical trial is to examine the effects of of neuromuscular electrical stimulation (NMES) training on physical activity, muscle function, self-efficacy, and blood markers [e.g.…
- Trial name
- NCT03509519
- Testing
- NMES-Millicurrent
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas State University
Duchenne Muscular Dystrophy
Dual Task in Duchenne Muscular Dystrophy
This study was planned to determine the effects of the dual-task performance of children with DMD with motor dysfunction and varying degrees of cognitive impairment compared to their healthy peers, to compare the dual-task…
- Trial name
- NCT05575648
- Testing
- 10 meter walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Hacettepe University