Clinical trials: Muscular Disorders, Atrophic
Chronic Kidney Disease, Sarcopenia
The QUALITY Vets Project: Muscle Quality and Kidney Disease
Currently there is no standard way to detect age-related skeletal muscle loss in patients with chronic kidney disease. Investigators are working on finding rapid and inexpensive ways to measure muscle size and fat within the…
- Trial name
- NCT03160326
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Muscular Atrophy, Spinal
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy
This is an open-label, single-arm, multicenter clinical study to evaluate the effectiveness and safety of risdiplam administered in pediatric participants with SMA and 2 SMN2 copies who previously received onasemnogene…
- Trial name
- HINALEA 2 (NCT05861999)
- Testing
- Risdiplam
- Where
- 17 sites in United States, Germany and 4 more
- Volunteers
- 19 people
- Sponsor
- Hoffmann-La Roche
Vitamin D Deficiency, Sarcopenia
Impact of Vitamin D on 25-hydroxyvitamin D Levels and Physical Function
This one-year study will test the hypothesis that supplementation with vitamin D will improve lower extremity muscle performance in older men and women with vitamin D insufficiency.
- Trial name
- NCT02293187
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tufts University
Gastric Cancer, Nutrition Related Cancer
Effect of Exercise and Enteral Nutrition on Survival
The present clinical trial was designed to explore the effect of postoperative physical exercise combined with enteral nutritional supplement on 3-year disease-free survival in patients with advanced gastric cancer.
- Conditions
- Gastric Cancer, Nutrition Related Cancer, Sarcopenia
- Trial name
- ENERGY (NCT05959226)
- Testing
- Exercise Intervention, Nutrition Intervention
- Volunteers
- 960 people
- Sponsor
- The First Hospital of Jilin University
Anterior Cruciate Ligament (ACL) Reconstruction
Subdermal Implant-bioabsorbable Oxandrolone Pellet For Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction
Rehabilitation of knee stability and function after anterior cruciate ligament (ACL) reconstruction is slow and costly. The use of anabolic steroids, such as oxandrolone, may aid in the recovery of muscle mass and strength, as…
- Trial name
- IMOX (NCT06974526)
- Testing
- Oxandrolone
- Where
- 6 sites in Brazil
- Volunteers
- 96 people
- Sponsor
- Science Valley Research Institute
Spinal Muscular Atrophy Type 3
Whole Body Vibration Therapy in Children With Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) are one of the common physical disabilities in childhood. For SMA, progressive muscle weakness and early fatigue hamper the mobility of the sufferers.
- Trial name
- NCT03056144
- Testing
- whole body vibration therapy
- Where
- Hong Kong
- Volunteers
- 1 people
- Sponsor
- The Hong Kong Polytechnic University
Sarcopenic Obesity, Sarcopenia
Lifestyle Modifications for the Treatment of Sarcopenic Obesity
This study evaluates the addition of a high-protein energy-restricted diet to exercise in the treatment of sarcopenic obesity in people aged 65 and over.
- Conditions
- Sarcopenic Obesity, Sarcopenia, Obesity
- Trial name
- NCT02379026
- Testing
- Protein Drink/Diet, Exercise, Vitamin D3
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Facioscapulohumeral Muscular Dystrophy
Bone Health in Facioscapulohumeral Muscular Dystrophy
This is a cross-sectional single visit study to determine bone health in individuals with FSHD.
- Trial name
- FSHD (NCT02413190)
- Where
- 2 sites in United States, Australia
- Volunteers
- 94 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
SMARD1, CMT2S
Gene Therapy for IGHMBP2-Related Diseases
Open-label, single intrathecal injection study of a AAV9 vector carrying the IGHMBP2 gene for IGHMBP2-related diseases.
- Trial name
- NCT05152823
- Testing
- Gene Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Megan Waldrop
Type 2 Diabetes, Sarcopenia
Sarcopenic Index and Related Factors in Patients With Type 2 Diabetes
Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is particularly common in individuals with T2DM and is often associated with insulin resistance, chronic inflammation and oxidative stress.
- Trial name
- NCT06539923
- Testing
- retrieving data
- Where
- Turkey (Türkiye)
- Volunteers
- 839 people
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Sarcopenia
Yijinjing Exercise for Musculoskeletal Health in Adults With Sarcopenia
Sarcopenia is a condition involving loss of muscle mass and strength that can make walking and other daily activities more difficult.
- Trial name
- NCT07871240
- Testing
- Modified Yijinjing Exercise, Progressive Resistance Training, Dietary Counseling and Health Education
- Where
- 6 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Stroke, Osteoporosis
Sarcopenia and Risk of Falls in Patients With Major Chronic Diseases
The objective of this study is to investigate the effects of therapeutic exercise and nutrition intervention for sarcopenia and risk of falls in patients with major chronic diseases.
- Conditions
- Stroke, Osteoporosis, Chronic Kidney Diseases, Cancer
- Trial name
- NCT03798418
- Testing
- elastic band strengthening exercise, diet counseling
- Where
- Taiwan
- Volunteers
- 186 people
- Sponsor
- Changhua Christian Hospital
Muscle Loss
Branched Chained Amino Acid Supplement in Patients Undergoing Lower Limb Bone Cancer Curettage for Bone Metastasis
Postoperative muscle loss is common in patients with bone metastases undergoing lower limb bone cancer curettage, affecting both limb skeletal muscles and potentially swallowing-related muscles.
- Trial name
- NCT06604910
- Testing
- branched chained amino acid
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Sarcopenia, Atrophy
Leucine Supplementation in Elderly Men
In the present study the investigators aim to determine whether leucine supplementation can augment muscle mass and strength and improve body composition in healthy elderly men
- Conditions
- Sarcopenia, Atrophy, Aging
- Trial name
- NCT00807508
- Testing
- leucine
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
FSHD, FSHD1
Phase 1/2 Study of AOC 1020 in Participants With Facioscapulohumeral Muscular Dystrophy (FSHD)
A Randomized, Double-blind, Placebo-controlled, Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Exploratory Efficacy of AOC 1020 Administered Intravenously to Participants with…
- Conditions
- FSHD, FSHD1, FSHD2, FMD
- Trial name
- FORTITUDE (NCT05747924)
- Testing
- AOC 1020
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 90 people
- Sponsor
- Avidity Biosciences, Inc.
Sarcopenia
Measurement of Sarcopenia at Post-stroke Rehabilitation Outcome
The purposes of this study are 1. To explore effect of sarcopenia on recovery of post stroke hemiplegia 2. To explore the effect of stroke on sarcopenia and relationship between the degree of sarcopenia and respiration and…
- Trial name
- NCT02793362
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bucheon St. Mary's Hospital
Rheumatoid Arthritis, Muscle Atrophy
Muscle Wasting and Rheumatoid Arthritis Flares
People living with Rheumatoid Arthritis (RA) often present with low muscle mass compared to their healthy counterparts. This affects their mobility, overall health and quality of life.
- Trial name
- NCT06400316
- Testing
- Amino Acid Supplement
- Volunteers
- 40 people
- Sponsor
- Leeds Beckett University
Glycogen Storage Disease Type 2, Dystrophia Myotonica
An MRI Study on Muscular Diseases -Pompe Disease and Dystrophia Myotonica-
The aim of the project is to develop new Magnetic Resonance (MR) imaging techniques for better diagnosis and monitoring of patients with muscular disorders.
- Trial name
- NCT02708784
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Metabolic Disorder, Lipid Metabolism Disorders
Randomized Clinical Trial of HMR(Home Meal Replacement)-Type Omega-3-balanced-diet
Investigate whether HMR(Home meal replacement)-type omega-3-balanced-diet can improve clinical laboratory values related to chronic metabolic diseases through reducing lipids and chronic inflammation, and can prevent muscle loss.
- Conditions
- Chronic Metabolic Disorder, Lipid Metabolism Disorders, Sarcopenia
- Trial name
- NCT04552574
- Testing
- HMR(Home meal replacement)-type omega-3-balanced diet
- Where
- South Korea
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Chungbuk National University Hospital
Spinal Muscular Atrophy Type I, Scoliosis
The Effect of Spinal Orthosis on the Development of Scoliosis and Chest Deformity in Type I Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a serious neuromuscular disease characterized by the degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle atrophy and denervation.
- Conditions
- Spinal Muscular Atrophy Type I, Scoliosis, Chest Deformities, Spinal Orthosis
- Trial name
- NCT05878418
- Testing
- Thoracolumbosacral Spinal Orthosis (TLSO), Trunk Exercise (TE), Pulmonary Rehabilitation(PR) and Pulmonary Care (PC)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medipol University