Clinical trials: Musculoskeletal Injury Trauma
Rhabdomyolysis
Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats
This study focuses on detecting the possible beneficial effect of Lactoferrin (Lf) administration on the kidney and the heart of glycerol-induced rhabdomyolysis (RM) in rats and its relation to ferroptosis and AMPK/Nrf2/ HO-1…
- Trial name
- NCT06491394
- Testing
- Lactoferrin, iron, MDA, TAC, and GSH
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Aswan University Hospital
Anterior Cruciate Ligament Injuries, Concussion, Brain
Making Football Safer for Women: Implementing an Injury Prevention Program
The aim of this study is to determine how we can best support coaches to implement an injury prevention (IP) program (Prep-to-Play) in female community Australian Football.
- Conditions
- Anterior Cruciate Ligament Injuries, Concussion, Brain, Musculoskeletal Injury
- Trial name
- Prep-to-Play (NCT04856241)
- Testing
- Coaching, Peer support, Educational materials
- Where
- Australia
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- La Trobe University
Chronic Musculoskeletal Pain, Sexual Assault
Post-traumatic Estradiol Administration and Care Evaluation (PEACE)
This pilot randomized, double-blind, placebo-controlled trial evaluates the feasibility, acceptability, and tolerability of administering a single 6 mg oral dose of 17β-estradiol (E2) to individuals assigned female at birth who…
- Conditions
- Chronic Musculoskeletal Pain, Sexual Assault, Posttraumatic Stress Disorder (PTSD)
- Trial name
- PEACE (NCT07868536)
- Testing
- 17β-estradiol
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Orthopedic Disorder
Open Reduction Internal Versus Percutaneous Sacroiliac Screw Fixation in Unstable Posterior Ring Injury of Pelvic
Surgical trearment of unstable posterior pelvic injuries can be performed with open reduction and internal fixation, closed reduction with percutaneous sacroiliac fixation.
- Trial name
- NCT05473611
- Testing
- closed reduction percutaneous fixation with open reduction internal fixation of the posterior pelvic ring
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Shoulder Impingement
Effects of PNF on Shoulder Pain in Paraplegic Manual Wheel Chair Users
This project was a Randomized control trial conducted to check the Effects of Proprioceptive Neuromuscular Facilitation on Shoulder Pain due to chronic impingement syndrome in paraplegic Manual Wheelchair users after Spinal Cord…
- Trial name
- NCT04967911
- Testing
- Rhythmic stabilization exercises, conventional treatment
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Osteoarthritis, RA
Surgical Tourniquets and Cerebral Emboli
BACKGROUND In 2012 76,497 primary total knee (TKR) replacements were performed in England, Wales and Northern Ireland . Traditionally TKR surgery is undertaken with the aid of a surgical tourniquet.
- Conditions
- Osteoarthritis, RA, Trauma
- Trial name
- NCT02240732
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Gonarthrosis, Diabetes
The Role of SCUBE-1 in Ischemia-reperfusion Injury
One consequence of tissue damage caused by tourniquet is ischemia-reperfusion injury. Short-term ischemia leads to vasodilatation and reactive hyperemia resulting in post-ischemic reperfusion microcirculation failure and tissue…
- Trial name
- NCT03389607
- Testing
- spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
ACL Injury, Meniscus Tear
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of…
- Conditions
- ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
- Trial name
- MOCHA (NCT04572256)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Austin V Stone
Fibromyalgia, Emotional Trauma
Hyperbaric Oxygen Therapy Compared to Pharmaceutical in Fibromyalgia With Emotional Trauma
The investigators have previously studied the efficacy of hyperbaric oxygen therapy (HBOT) as a treatment for Fibromyalgia syndrome (FMS) in a prospective, active control, crossover clinical trial.
- Trial name
- NCT04316702
- Testing
- Hyperbaric oxygen therapy (HBOT) treatment, Cymbalta / Lyrica - Drug treatment
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Assaf-Harofeh Medical Center
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Chronic Pain, Low Back Pain
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
The purpose of this study is to investigate, in two phases: (1) the feasibility and safety of Virtual Embodiment Therapy in treating chronic pain of lower back and upper limbs and (2) the efficacy of Virtual Embodiment Therapy on…
- Conditions
- Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction
- Trial name
- NCT04060875
- Testing
- Karuna Labs Virtual Reality Software
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karuna Labs Inc.
Musculoskeletal Injury
The DCU Running Injury Surveillance Centre Study: A Prospective Investigation of Factors Relating to Running Injuries
This study aims to prospectively investigate the relationship between a number of clinical and biomechanical variables and running-related injuries among a group of novice and recreational runners over a two year time period.
- Trial name
- DCU RISC (NCT03671395)
- Where
- Ireland
- Volunteers
- 315 people
- Sponsor
- Dublin City University
Osteoarthritis, Knee
Efficacy of Allogeneic UCMSCs for Treating Large Defects Knee Injury
In terms of the surgical treatment of the cartilage injury, various techniques and ways are created to repair or regenerate articular surface of synovial joint following traumatic damage or degeneration of the cartilage.
- Trial name
- NCT05016011
- Testing
- Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), Marrow cellution
- Where
- Malaysia
- Volunteers
- 28 people
- Sponsor
- Cytopeutics Sdn. Bhd.
Muscle Atrophy, Cachexia
Vitamin K2 Supplements for Muscle Recovery
Ankle injury is one of the most common injuries which can have long term consequences. Ankle immobilization is often applied for up to six weeks to ensure healing of the soft tissue and fractured bones after such an injury.
- Trial name
- Recovery (NCT05161975)
- Testing
- Vitamin K2
- Where
- 2 sites in Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Spinal Cord Injury, Spasticity
Co-contraction and Corticoreticular Excitability in Spinal Cord Injury
This study is to elucidate whether hyperexcitability of the cortico-reticulospinal tract leads to abnormal co-contraction and spasticity of elbow flexors in persons with cervical cervical spinal cord injury.
- Trial name
- NCT07872839
- Testing
- Corticoreticular excitability and co-contraction measurement
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Spinal Cord Injuries, Spina Bifida
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
The goal of this clinical trial is to learn about how a participation-based intervention builds capacity of youth with physical disabilities to pursue activities of their choice in the community.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT06007885
- Testing
- Pathways and Resources to Engagement and Participation (PREP)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
Pneumonia, Syncope
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness.
- Conditions
- Pneumonia, Syncope, Congestive Heart Failure, Cellulitis
- Trial name
- NDC (NCT06526884)
- Testing
- Next Day Clinic
- Where
- United States
- Volunteers
- 570 people
- Sponsor
- University of California, Los Angeles
Spine Injury, Hamstring Injury
Effect of a Flexibility Program on the Extensibility of the Hamstrings and the Thoracic and Lumbar Spinal Curvatures
The goal of this clinical trial is to analyse the effect of an intervention program based on hamstring flexibility on the extensibility and curvatures of the spine in dancers.
- Conditions
- Spine Injury, Hamstring Injury, Lumbar Hyperlordosis, Kyphosis
- Trial name
- NCT05904834
- Testing
- Flexibility training
- Where
- Spain
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Orthopedic Disorders, Trauma
A Survey of Google Glass by Orthopaedic Trauma Patients and Surgeons
Patients seen in the Orthopaedic Trauma clinic will be asked to consent for potential video/picture recording using the Google Glass device during their visit with the orthopaedic surgeon or resident.
- Trial name
- GoogleGlass (NCT02221115)
- Testing
- Google Glass
- Where
- Canada
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre