Clinical trials: Myocardial Diseases
Coronary Artery Disease
CompArison of PCI in NaTive Arteries Versus ByPAss Grafts In PatieNts With Prior CABG (CAPTAIN)
Coronary atherosclerotic heart disease (CAD) has been considered the leading cause of death in both developed and developing countries.
- Trial name
- NCT05368597
- Testing
- PCI in native vessel or in bypass graft
- Where
- China
- Volunteers
- 1,491 people
- Sponsor
- Beijing Anzhen Hospital
Cardiovascular Diseases, Heart Diseases
Epidemiology of Coronary Heart Disease in Blacks
To conduct an analysis of the epidemiology of coronary heart disease (CHD) in Blacks using data collected from the 'Survival and Ventricular Enlargement (SAVE) Following Myocardial Infarction' study.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00005410
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Apposition Assessed Using Optical Coherence Tomography of Chromium Stents Eluting Everolimus From Cobalt Versus Platinum Alloy Platforms
The purpose of the trial is to directly compare the Cobalt Chromium platform everolimus-eluting stent, Xience Prime™, with the Platinum Chromium platform everolimus-eluting stent, Promus Element™, in relation to stent scaffolding…
- Trial name
- APPOSE (NCT01776567)
- Testing
- Everolimus eluting stents
- Where
- 4 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Northern Hospital, Australia
Chest Pain, Acute Coronary Syndrome
Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
This multi-center, randomized, controlled trial conducted in Emergency Departments (ED) compares computed tomography (CT) coronary angiography with the traditional approach (usual care) for low- to intermediate-risk chest pain…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT00933400
- Testing
- CT Coronary Angiography (CTCA), Traditional Strategy
- Where
- 5 sites in United States
- Volunteers
- 1,392 people
- Sponsor
- American College of Radiology
Cardiovascular Diseases, Hypertension
Children's Activity and Nutrition III
To track blood pressure from childhood through adolescence.
- Conditions
- Cardiovascular Diseases, Hypertension, Coronary Disease
- Trial name
- NCT00007111
- Sponsor
- Augusta University
Coronary Artery Disease
Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease
The recommended antiplatelet treatment regimen for patients affected by acute coronary syndromes (ACS) and those undergoing percutaneous coronary intervention (PCI) consists in the combination of aspirin and a P2Y12 receptor…
- Trial name
- SWAP-4 (NCT02287909)
- Testing
- Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Florida
Cardiogenic Shock
Scoring Model for Predicting Outcome in Patients With Cardiogenic Shock
This study aims to develop a predictive model for the outcomes of patients with cardiogenic shock
- Trial name
- NCT04850248
- Testing
- no intervention, this is an observational study
- Volunteers
- 999 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease (CAD), Atherosclerosis of Coronary Artery
High Risk Atherosclerosis Identified at Cardiac CT Among Patients With vs Without Family History of CAD
Acute coronary syndrome often represtent the first drammatic manifestation of coronary atherosclerosis. Cardiac computed tomography angiography (CCTA) has recently gained a pivotal role in the evalution of patients with suspected…
- Trial name
- NCT07172308
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Coronary Disease, Weight Loss
Time Restricted Feeding for Weight Loss and Cardio-protection
Time restricted feeding (TRF) is a novel form of intermittent fasting that involves confining the period of food intake to 8 h/d (e.g. 10 am to 6 pm) without calorie counting.
- Trial name
- NCT02948517
- Testing
- Time restricted feeding
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Myocardial Infarction
Changes in Regional and Global Cardiac Contractility After Stimulation in Scar Zone With the NOGA System
Despite a decrease in voltage amplitude in post-infarction scar areas, greater voltage amplitudes are sometimes observed at the time of local extrasystoles mechanically induced by catheters.
- Trial name
- SCARPACE (NCT04757168)
- Testing
- NOGA TM probe
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
MACE, Cardiac Death
Real-World Cohort Study of Cardiopulmonary Function in Chinese Patients With Cardiovascular Disease: CPET Evaluation and Five-Year Prognostic Follow-Up Based on a Multicenter Structured Data Platform
The goal of this observational study is to observe the characteristics of cardiopulmonary exercise testing (CPET) parameters in patients across different cardiovascular diseases and to evaluate the predictive value of…
- Conditions
- MACE, Cardiac Death, Unplanned Repeat Revascularization, Cardiac Rehospitalization
- Trial name
- China-CPET (NCT07130968)
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Dilated Cardiomyopathy
Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy
This study is designed to assess the safety profile and the efficacy of cardiac repair cells (CRCs) administered via catheter in treating patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT01020968
- Testing
- Ixmyelocel-T, Vehicle Control
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Vericel Corporation
Myocardial Injury, Connective Tissue Diseases
Effect of Sacubitril/Valsartan on Reduced Right Ventricular Ejection Fraction in Patients With CTD
Heart failure, one of the leading causes of connective tissue disease (CTD) mortality, has attracted increasing attention. Currently, no known study had focused on the effect of sacubitril/valsartan on right ventricular…
- Trial name
- EARLY-MYO-CTD (NCT04197050)
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Hypertrophic Cardiomyopathy (HCM)
The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction
This study is a prospective interventional cohort study aimed at evaluating the therapeutic efficacy and clinical utility of Mavacamten-a targeted myosin inhibitor specifically developed for obstructive hypertrophic…
- Trial name
- BRAVE-HCM (NCT07103655)
- Testing
- mavacamten, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol, diltiazem
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Myocardial Ischaemia
The FAVOR III China Study
The overall purpose of the FAVOR III China trial is to investigate if a strategy of quantitative flow ratio (QFR)-guided percutaneous coronary intervention (PCI) yields superior clinical outcome and cost-effectiveness compared to…
- Conditions
- Coronary Artery Disease, Myocardial Ischaemia, Coronary Circulation, Coronary Stenosis
- Trial name
- FAVORIII (NCT03656848)
- Testing
- QFR, Angiography
- Where
- China
- Volunteers
- 3,847 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
The Association Between Central Aortic Blood Pressure Indices and Severity of Coronary Artery Disease
Abstract Objectives: Primary: To study the association between central aortic blood pressure indices and coronary artery disease in patients undergoing elective angiography.
- Trial name
- CAPCAD (NCT02471768)
- Testing
- CORONARY ANGIOGRAM AND CENTRAL AORTIC WAVEFORM ANALYSIS
- Volunteers
- 623 people, healthy volunteers welcome
- Sponsor
- Government Medical College, Kozhikode
Coronary Artery Disease, Coronary Stenosis
Reverse T-stenting and Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation
The Reverse T-stenting And Minimal Protrusion (Reverse TAP) is an up-front 2-stent technique that treats complex coronary bifurcation.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Coronary Disease
- Trial name
- T-REX (NCT05782738)
- Testing
- Percutaneous Coronary Intervention
- Where
- 5 sites in Italy
- Volunteers
- 361 people
- Sponsor
- San Luigi Gonzaga Hospital
Acute Coronary Syndrome, Myocardial Infarction
Cangrelor vs. Ticagrelor for Early Platelet Inhibition in STEMI
This randomized, controlled trial compares the anti-thrombotic effect of cangrelor and ticagrelor on platelet activity in patients with acute ST-elevation myocardial infarction.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- CanTi (NCT03182855)
- Testing
- Ticagrelor, Cangrelor Tetrasodium
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Sudden Cardiac Death, Myocardial Infarction
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
Patients who have survived a myocardial infarction (MI) are at increased risk for sudden cardiac death (SCD) caused by ventricular tachycardia and ventricular fibrillation.
- Trial name
- PROFID EHRA (NCT05665608)
- Testing
- Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT)
- Where
- 86 sites in Austria, Belgium and 11 more
- Volunteers
- 3,595 people
- Sponsor
- Charite University, Berlin, Germany
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter
The purpose of this study is to assess the safety and feasibility of the investigational catheter for mapping the atrial and ventricular regions of the heart.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- FEATHER (NCT07116525)
- Testing
- Paddle-Shaped, High-Density, Multi-Electrode Mapping Catheter
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 90 people
- Sponsor
- Biosense Webster, Inc.