Clinical trials: Myocardial Fractional Flow Reserve
Perfusion Imaging, MRI
MRI Perfusion Imaging at 3Tx Compared to Invasive FFR Measurements
Coronary artery disease (CAD) has a great significance concerning prevalence and mortality in the western world. It is usually diagnosed by catheterization and coronary arteries are visually assessed by the examiner.
- Conditions
- Perfusion Imaging, MRI, Myocardial Fractional Flow Reserve, Myocardial Ischemia
- Trial name
- Vision MRT (NCT01277055)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heart Center Bogenhausen
ST Segment Elevation Myocardial Infarction
Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Non Culprit Lesions in Patients With ST-segment Elevation Myocardial Infarction
Functional assessment of non-culprit lesions during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome could improve risk stratification and shorten the duration of hospital stay by decreasing the…
- Trial name
- WAVE (NCT02869906)
- Testing
- FFR and iFR
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Coronary Artery Disease
Comparison of Cardiac Imaging Techniques for Diagnosing Coronary Artery Disease
A large number of cardiac catheterizations are performed each year, primarily to diagnose heart disease. However, a cardiac catheterization is an invasive procedure which is associated with serious complications such as heart…
- Trial name
- PACIFIC (NCT01521468)
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Vessels, Endothelins
Endothelin-Receptor Blockade in Coronary Heart Disease
Endothelin is a hormon that causes acute and chronic narrowing of heart vessels. The purpose of this study is to assess whether suppression of this activity by using two types of receptor antagonists can reduce this effect and…
- Conditions
- Coronary Vessels, Endothelins, Vascular Resistance
- Trial name
- NCT00427232
- Testing
- BQ-123 and BQ-788
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Diagnostic Accuracy of CFD-Based Fractional Flow Reserve Derived From Coronary Angiography
This is a prospective, multicenter, self-control clinical trial designed to assess the efficacy of AccuFFRangio, a novel method for evaluating the functional significance of coronary stenosis from coronary angiography, with FFR…
- Trial name
- ACCURATE (NCT04814550)
- Testing
- FFR
- Where
- China
- Volunteers
- 318 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Non-obstructive Coronary Disease, Acute or Chronic Coronary Artery Disease
Simultaneous Measurement of EpicArdial and Microvascular ResisTance Via Angiographic FLOW Study
The aim of this study is to establish the diagnostic performance of the AngioAI+ System (AngioInsight, Inc, USA) for estimating: 1. Fractional flow reserve (FFR) and 2.
- Trial name
- SMARTFLOW (NCT07676097)
- Testing
- Patients with intermediate coronary artery stenosis with clinically indicated FFR assessment., Microvascular assessment
- Where
- 9 sites in United States
- Volunteers
- 620 people
- Sponsor
- AngioInsight
Coronary Artery Stenosis
Fractional Flow Reserve and Intravascular Ultrasound in Evaluating Intermediate Coronary Lesions
Recent studies have shown that optimal IVUS criteria defining the functional significance (FFR < 0.8) of intermediate coronary stenoses is different according to their locations of the coronary tree.
- Trial name
- NCT01414361
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Fracational Flow Reserve, Coronary Artery Disease
Preoperative Use of Fractional Flow Reserve in CABG Use and Effectiveness of FFR-based CABG in Real-life Practice
The use of fractional flow reserve (FFR) to guide coronary artery bypass graft (CABG) is controversial and not ubiquitously adopted across the units.
- Conditions
- Fracational Flow Reserve, Coronary Artery Disease, Coronary Artery Bypass Surgery
- Trial name
- NCT04379947
- Testing
- Fractional Flow reserve
- Sponsor
- University of Glasgow
Coronary Artery Disease, Coronary Stenosis
Comparison of Devices Evaluating Fractional Flow Reserve in Coronary Arteries
The aim of the study is to compare different devices available to measure fractional flow reserve (FFR) in coronary arteries.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Myocardial Ischemia
- Trial name
- FFR-DS (NCT03052803)
- Testing
- Fractional flow reserve measure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease, Echocardiography, Stress
New Three-dimensional Methods of Analysis for the Detection of Coronary Artery Disease by Dobutamine Stress Echocardiography
The investigators are going to recruit patients who have a scheduled elective coronary angiography and going to do a dobutamin stress echography (DSE) before the coronary examination.
- Trial name
- 3-DSE (NCT02240745)
- Testing
- Stress-echocardiography
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Functional Assessment of Coronary Artery Disease by CTA Flow Encoding
The purpose of this pilot study proposal is to test the ability of Transluminal Flow Encoding (TAFE) to evaluate vessel specific ischemia in patients with a clinical indication for invasive coronary angiography (ICA) with…
- Trial name
- NCT02286401
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Acute ST-segment Elevation Myocardial Infarction
Prognostic Implication of Angiography-Derived IMR in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of STEMI patients. Previous study presented that index of microcirculatory resistance (IMR) in culprit vessel of STEMI…
- Trial name
- NCT04628377
- Testing
- Angiography-drived Index of Microcirculatory Resistance
- Volunteers
- 333 people
- Sponsor
- Samsung Medical Center
Fractional Flow Reserve
DSE vs Invasive FFR vs CT-FFR
Data are limited regarding the optimal treatment of the non-culprit lesions (NCL) after myocardial infarction (MI). The NON-CULPRIT study is a prospective cohort study with a primary aim to compare invasive fractional flow…
- Trial name
- NON-CULPRIT (NCT03988881)
- Testing
- Revascularization
- Where
- 2 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Coronary Artery Disease
Vascular Evaluation for Revascularization: Defining the Indications for Coronary Therapy: A Pilot Study
The present prospective, multicenter study will therefore be performed with the primary objective of establishing the correlation between fractional flow reserve (FFR) and intravascular ultrasound with virtual histology…
- Trial name
- VERDICT (NCT01158053)
- Testing
- FFR and VH-IVUS, IVUS and FFR
- Volunteers
- 291 people
- Sponsor
- Volcano Corporation
Angina
Ranolazine Among Unrevascularized Chronic Stable Angina Patients
This is a prospective, double-blind, placebo-controlled, randomized, single-center (North Florida- South Georgia VA Medical Center) study.
- Trial name
- IMWELL (NCT02265796)
- Testing
- Ranolazine, Sugar pill
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Florida Foundation for Research and Education
Coronary Angiography, Fractional Flow Reserve, Myocardial
Fractional Flow Reserve Derived From CT Related Treatment
This study is a retrospective, single-center study.This experiment aims to explore the influence of CT-FFR as a relevant for revascularization on the prognosis of patients with coronary heart disease, assessing concurrent on…
- Conditions
- Coronary Angiography, Fractional Flow Reserve, Myocardial, Coronary Artery Disease
- Trial name
- NCT05319119
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease
The Effect of GRAVITY on Physiological Measurements During Invasive Coronary Angiography and Intervention
This is a single centre observational study on the impact of change in patient position and hence gravity, on physiological measurements in coronary arteries.
- Trial name
- GRAVITY (NCT03097172)
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Coronary Artery Disease
Influence of Lipid Lowering on Impaired Coronary Flow
This study assess in patients with stable chest pain and coronary artery disease (CAD) determined by coronary CTA whether cholesterol lowering with regression of coronary adverse plaque characteristics is associated with recovery…
- Trial name
- NCT05368545
- Testing
- High intensity lipid lowering
- Where
- Denmark
- Volunteers
- 109 people
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease (CAD)
Evaluation of XTR004 as a Novel 18F-labeled PET MPI Tracer in Diagnosis of Known or Suspected CAD
The diagnostic efficacy and safety of the XTR004 myocardial perfusion PET imaging tracer are evaluated for known or suspected CAD with the use of invasive coronary angiography as the reference standard for the diagnosis of CAD…
- Trial name
- NCT05885841
- Testing
- XTR004
- Where
- 2 sites in China
- Volunteers
- 83 people
- Sponsor
- Sinotau Pharmaceutical Group
Coronary Artery Disease
CABG Based on CT-FFR Versus Conventional Coronary Angiography
The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed…
- Trial name
- NCT06028165
- Testing
- Coronary artery bypass grafting based on conventional coronary angiography, Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Myongji Hospital