Clinical trials: Myocardial Function
Chronic Ischaemic Heart Failure
Bone Marrow Derived Adult Stem Cells for Chronic Heart Failure
The purpose of this study is to determine whether adult bone marrow derived stem/progenitor cells improve cardiac function and symptoms in patients with heart failure and to establish the optimal method of delivery of these…
- Trial name
- REGEN-IHD (NCT00747708)
- Testing
- Granulocyte-colony stimulating factor, Percutaneous intracoronary injection, Percutaneous intramyocardial injection
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Barts & The London NHS Trust
Androgen Deficiency, AD
Hormones and Sexual Function Predict Outcomes in Revascularized Men With Diabetes
The purpose of this study is to find out if androgen deficiency (low levels of testosterone, a male hormone produced by the sex glands) and erectile dysfunction (sexual dysfunction) will predict over time the development of a…
- Conditions
- Androgen Deficiency, AD, Erectile Dysfunction, ED
- Trial name
- HEART-MEND (NCT01190904)
- Where
- 5 sites in United States
- Volunteers
- 568 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Artery Disease
Effect of Folic Acid Treatment in Coronary Artery Disease
We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function
- Trial name
- NCT00300352
- Testing
- Folic Acid
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Coronary Artery Disease
Platelet Function Assessment for Atherothrombotic Patients
Background-Despite the pivotal pathogenic role of platelets in atherothrombosis has been widely recognized, there is a striking lack of consensus regarding how to measure platelet function and how to monitor the effects of…
- Trial name
- NCT00513149
- Testing
- Clopidogrel
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Myocardial Infarction
EMpagliflozin to PREvent worSening of Left Ventricular Volumes and Systolic Function After Myocardial Infarction
The addition of the SGLT2 inhibitor empagliflozin 10mg once daily to standard-of-care therapy administered early following acute myocardial infarction will result in a greater attenuation of adverse left ventricular remodelling…
- Trial name
- EMPRESS-MI (NCT05020704)
- Testing
- Empagliflozin 10 MG
- Where
- 3 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- NHS Greater Glasgow and Clyde
Type 2 Diabetes Mellitus
Insulin Effects on Metabolism and Cardiovascular Function in Type 2 Diabetes
Compared to human insulins analogue insulins offer the option of optimizing metabolism also in type 2 diabetes. Especially, fast acting insulin analogues lower postprandial glucose levels more effectively than human regular…
- Trial name
- NCT00747409
- Testing
- insulin aspart and detemir (NovoRapid, Levemir), human regular insulin and NPH insulin (Actrapid, Protaphne)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Munich Municipal Hospital
Myocardial Infarction
Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
The broad objective is to advance our understanding of both in vivo anatomical and functional changes that are present in the coronary arteries in women who have an acute coronary syndrome.
- Trial name
- NCT00587002
- Testing
- IVUS
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic
Peripheral Artery Disease
Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety
Based upon evidence of efficacy and safety of both cilostazol and probucol administration in independent randomized controlled trials in PAD and CAD, the present trial seeks to investigate the effect of concomitant administration…
- Trial name
- NCT01142284
- Testing
- Cilostazol, Probucol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Coronary Artery Disease, Aortic Valve Stenosis
Functional Assessment in TAVI: FAITAVI
The aim of this study is to compare the clinical outcome of patients with severe aortic valve stenosis and associated significant coronary artery disease treated with TAVI and a percutaneous myocardial revascularization dictated…
- Trial name
- FAITAVI (NCT03360591)
- Testing
- Physiologically-guided strategy
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Universita di Verona
Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention
The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease
The purpose of this study is to investigate the effect of percutaneous coronary intervention (PCI) on cardiac function in multi-vessel disease patients with concurrent chronic total occlusion (CTO) lesion.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Coronary Artery Disease, Viable Myocardium
- Trial name
- SOS-moral (NCT03372785)
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. stents or coronary balloons
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
Impact of Vascular Reparative Therapy on Vasomotor Function and Myocardial Perfusion:a Randomized H215O PET/CT Study
The purpose of this study is to examine the improvement of myocardial blood flow induced by regained vasomotor functions of the stented coronary segment after resorption of BVS over time.
- Trial name
- VANISH (NCT01876589)
- Testing
- Bioresorbable vascular scaffold, Xience Prime
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Anterior Myocardial Infarction, Heart Failure
RIGENERA 2.0 Trial
Study Objectives: To determine whether, in patients with large acute myocardial infarction undergoing primary or rescue angioplasty, the administration of subcutaneous Lenograstim [recombinant human Granulocyte-Colony Stimulating…
- Trial name
- RIGENERA (NCT02502747)
- Testing
- rhu G-CSF, optimal standard of care, Myocardial Contrast Echocardiography
- Where
- Italy
- Sponsor
- Catholic University of the Sacred Heart
Myocardial Infarct, Remodeling, Left Ventricle
Heart Attack Blood Oxygen Therapy Trial
'Heart attack', known as acute ST-segment elevation myocardial infarction, is a leading cause of heart failure and death. A lack of blood and oxygen damages the heart muscle potentially causing heart failure and premature death.
- Trial name
- SSO2 Radial MI (NCT06662890)
- Testing
- Supersaturated oxygen
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- NHS National Waiting Times Centre Board
Stable Angina
Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina
ORBITA-FIRE is a randomised, double-blinded, placebo controlled experimental study that will identify the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) thresholds that correlate with symptoms of angina for…
- Trial name
- ORBITA-FIRE (NCT05459051)
- Testing
- Rest-angina physiological assessment, Exercise-angina physiological assessment
- Where
- 6 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- Imperial College London
Acute Coronary Syndrome
Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment For Acute Coronary Syndromes Trial
This study investigates whether a platelet function testing guided approach with a short-term (1 week) prasugrel treatment and a switch over to clopidogrel treatment in adequate responders to clopidogrel is non-inferior regarding…
- Trial name
- TROPICAL-ACS (NCT01959451)
- Testing
- Prasugrel, Clopidogrel
- Where
- 33 sites in Austria, Germany and 2 more
- Volunteers
- 2,600 people
- Sponsor
- LMU Klinikum
Healthy
Myocardial Fibrosis, Function and Aging
In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age.
- Trial name
- MARVEL (NCT03064503)
- Testing
- Blood sampling, MRI, Skin auto-fluorescence
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cardiac Surgery Subjects
Effect of PEEP on Cardiac Function
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.
- Trial name
- NCT07531602
- Testing
- EIT Guided PEEP Trial
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiovascular Diseases, Hypertension
IV Hydrogen Nanobubbles for Cardiac Function and QoL
The goal of this clinical trial is to learn if intravenous hydrogen nanobubbles (HNBs) improve cardiovascular function and quality of life in adults.
- Conditions
- Cardiovascular Diseases, Hypertension, Blood Pressure
- Trial name
- HNB (NCT07085637)
- Testing
- intravenous infusion of hydrogen nanobubbles (HNB) administered twice weekly over a 5-week period
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Indonesia Molecule Institute
Chronic Liver Disease, Thyroid Disease
The Development of Quantitative Ultrasound Imaging Software Platform
The goal of this observational study is to compare the image differences between conventional ultrasound and artificial intelligence-based ultrasound software in conscious adults.
- Conditions
- Chronic Liver Disease, Thyroid Disease, Benign Breast Disease, Malignant Breast Neoplasm
- Trial name
- NCT05836246
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function
The study aims to investigate whether oral betablocker (BB) therapy is superior to no such treatment following an acute myocardial infarction (AMI).
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- BETAMI (NCT03646357)
- Testing
- Non-betablocker, Betablocker
- Where
- 20 sites in Norway
- Volunteers
- 2,895 people
- Sponsor
- Oslo University Hospital