Clinical trials: Myocardial Ischaemia
Acute Coronary Syndrome
FRANCIS-ACS Trial: A Study of the Safety and Efficacy of A 002 in Subjects With Acute Coronary Syndromes
The objective of this study is to evaluate the safety and efficacy of A 002 when added to high dose atorvastatin in subjects with an acute coronary syndrome (ACS)
- Trial name
- FRANCIS-ACS (NCT00743925)
- Testing
- Varespladib Methyl (A-002)
- Where
- 44 sites in Georgia, Russia and 1 more
- Volunteers
- 625 people
- Sponsor
- Anthera Pharmaceuticals
Coronary Artery Disease
Sirolimus-Eluting BX VELOCITYTM Balloon-Expandable Stent in a Compassionate Use Registry (SECURE)
The objective of this study is to allow treatment with the sirolimus-eluting Bx VELOCITYTM stent in patients with a serious disease or condition for which there is no generally acceptable alternate treatment available.
- Trial name
- NCT00231244
- Testing
- CYPHER Sirolimus-Eluting Coronary Stent
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Cordis US Corp.
Angina, Unstable, Angioplasty, Transluminal, Percutaneous Coronary
A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-platelet Therapy, in Patients Undergoing High-risk Coronary Angioplasty
The purpose of this study is to evaluate the effectiveness and safety of abciximab (an anti-platelet therapy) versus placebo in patients undergoing high risk coronary angioplasty.
- Trial name
- NCT00269893
- Testing
- Abciximab
- Volunteers
- 2,038 people
- Sponsor
- Centocor, Inc.
Cardiomyopathies, Heart Failure, Congestive
A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart Failure When Natrecor (Nesiritide) is Added to Standard-Care Therapy, Compared to Administration of Placebo With Standard-Care Therapy
The purpose of this pilot study is to compare the clinical effects, safety profile, and economic impact of standard therapy plus Natrecor® (nesiritide, a recombinant form of the natural human peptide normally secreted by the…
- Conditions
- Cardiomyopathies, Heart Failure, Congestive, Dyspnea, Paroxysma
- Trial name
- NCT00270387
- Testing
- Natrecor (nesiritide)
- Volunteers
- 250 people
- Sponsor
- Scios, Inc.
Coronary Artery Disease
Safety and Preliminary Effectiveness Study of Mesenchymal Stem Cells, HeXell-2020, in Patients With Stable Coronary Artery Disease
This is a phase I/IIa study to investigate the safety, tolerability, and preliminary effectiveness of HeXell-2020 in patients with stable coronary artery disease (CAD).
- Trial name
- NCT07137104
- Testing
- HeXell-2020
- Where
- Taiwan
- Volunteers
- 39 people
- Sponsor
- Hexun Biosciences Co., LTD.
Coronary Artery Disease
V-Flex Plus PTX Drug Eluting Coronary Stent
The study is intended to collect data to evaluate effectiveness and safety of drug eluting stent devices in a dose ranging assessment.
- Trial name
- ELUTES III (NCT00225693)
- Testing
- drug eluting coronary stent
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Cook Group Incorporated
Coronary Artery Disease
Study of ONO-1101 in Patients Scheduled for Coronary Angiography
The purpose of this study is to evaluate the efficacy and safety of ONO-1101 in patients scheduled for coronary angiography, in a double-blind, randomized, placebo-controlled, parallel group, multi-center study.
- Trial name
- NCT00560209
- Testing
- ONO-1101
- Where
- Japan
- Volunteers
- 183 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Coronary Artery Disease
ADVANCE MPI 1: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI)
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately.
- Trial name
- NCT00208299
- Testing
- Regadenoson, Adenosine
- Where
- United States
- Volunteers
- 1,231 people
- Sponsor
- Gilead Sciences
Angina, Stable
Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease
The purpose of this study is to determine whether a single intracoronary infusion of Ad5FGF-4, delivered during induced transient ischemia, is effective in improving myocardial perfusion, angina functional class, patient…
- Trial name
- ASPIRE (NCT01550614)
- Testing
- Alferminogene tadenovec
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- Cardium Therapeutics
Coronary Disease, Coronary Artery Disease
EXecutive Registry: Evaluating XIENCE V® in a Multi Vessel Disease
The purpose of this two part study is the assessment of the performance of the XIENCE V® Everolimus Eluting Coronary Stent System (XIENCE V® EECSS) in the treatment of the specific setting of patients with Multi-Vessel Coronary…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis
- Trial name
- EXecutive (NCT01310309)
- Testing
- Coronary artery placement of a drug-eluting stent
- Where
- 23 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
A Trial of DCB vs DES in the Treatment of de Novo Large Diameter Coronary Atherosclerotic Stenosis(LARGE ONE)
For the treatment of primary large-diameter coronary atherosclerosis through percutaneous coronary intervention (PCI), the use of a drug balloon (DCB) is not inferior to the placement of a drug-eluting stent (Firehawk™ family).
- Trial name
- LARGE-ONE (NCT05961787)
- Testing
- SeQuent® Please drug coating balloon(DCB)，Firehawk family drug eluting stent(DES)
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Healthy Volunteers
Study to Compare the Pharmacodynamics and Pharmacokinetics of Acetylsalicylic Acid Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Healthy Adults.
The goal of this clinical trial is to compare the pharmacodynamics (PD), pharmacokinetics (PK), safety, and tolerability of acetylsalicylic acid powder for oral inhalation (i-ASA) with non-enteric-coated chewable aspirin (C-ASA)…
- Trial name
- NCT05625334
- Testing
- ASA, non-enteric-coated chewable aspirin
- Where
- 2 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Vectura, Inc.
Coronary Artery Disease
Supralimus-Core™ Pharmacokinetic (PK) Study
The primary objective of this study is to evaluate the pharmacokinetic (PK) and safety associated with Supralimus-Core™ Sirolimus Eluting Coronary Stent system in the treatment of single de novo lesions in native coronary…
- Trial name
- NCT01121744
- Testing
- Supralimus-Core™ Sirolimus eluting Coronary Stent
- Where
- 4 sites in India
- Volunteers
- 20 people
- Sponsor
- Sahajanand Medical Technologies Limited
Coronary Atherosclerotic Disease, Coronary Occlusive Diseases
COMPETE: A Clinical Evaluation of Chrono Carbostent Carbofilm™ Coated Stent
The COMPETE study is a prospective,randomized,two-arm multi-center clinical trial comparing two commercially available coronary stents: Chrono Carbostent Carbofilm™ Coated vs Driver/Micro-Driver Coronary Stent System.
- Conditions
- Coronary Atherosclerotic Disease, Coronary Occlusive Diseases, Coronary Artery Diseases, Myocardial Ischemia
- Trial name
- COMPETE (NCT00920283)
- Testing
- Chrono Carbostent Carbofilm™ Coated Coronary Stent, Driver Cobalt Alloy Coronary Stent
- Where
- 6 sites in Italy
- Volunteers
- 205 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI
The purpose of this study is to see whether apadenoson is as effective as adenosine when used as a pharmacological stress agent in myocardial SPECT-imaging (SPECT-MPI)to detect defects in the supply of blood to the heart muscle…
- Trial name
- ASPECT2 (NCT01313572)
- Testing
- Apadenoson SPECT-MPI, Adenosine SPECT-MPI
- Where
- 86 sites in United States, Argentina and 3 more
- Volunteers
- 197 people
- Sponsor
- Forest Laboratories
Coronary Artery Disease
FAME II-10-year Follow-Up
The FAME-II trial was a prospective, multicenter, multinational, multi-continental, randomized clinical trial with an 'all comers' design.
- Trial name
- FAME2-10yFU (NCT06159231)
- Where
- 16 sites in United States, Belgium and 9 more
- Volunteers
- 888 people
- Sponsor
- CoreAalst BV
Ischemic Heart Disease, Stenotic Coronary Lesion
China Resolute Integrity 34/38 mm Study
To evaluate the clinical safety and efficacy in Chinese subjects, eligible for percutaneous transluminal coronary angioplasty (PTCA) in lesions amenable to treatment with a 34/38 mm Medtronic Resolute Integrity™…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03118531
- Testing
- Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System(34/38 mm)
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Medtronic Vascular
Coronary Artery Disease
Vascular Evaluation for Revascularization: Defining the Indications for Coronary Therapy: A Pilot Study
The present prospective, multicenter study will therefore be performed with the primary objective of establishing the correlation between fractional flow reserve (FFR) and intravascular ultrasound with virtual histology…
- Trial name
- VERDICT (NCT01158053)
- Testing
- FFR and VH-IVUS, IVUS and FFR
- Volunteers
- 291 people
- Sponsor
- Volcano Corporation
STEMI
The First-In-Man Use of Coronary Sinus Balloon Pump in STEMI Patients Treated by Primary PCI
This is a prospective, multicenter clinical investigation aiming to evaluate the safety and efficacy of the coronary sinus balloon pump in its first application in patients with acute ST-segment elevation myocardial infarction…
- Trial name
- REVIVE-FIM (NCT07082153)
- Testing
- the coronary sinus balloon pump
- Volunteers
- 10 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Stable Coronary Artery Disease
A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Coronary Artery Disease
The goal of this study is to find out if a drug called selatogrel (ACT-246475) can prevent platelets from binding together when administered by an injection under the skin in the thigh or in the belly.
- Trial name
- NCT03384966
- Testing
- Selatogrel
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 346 people
- Sponsor
- Viatris Innovation GmbH
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