Clinical trials: Myocardial Protection
Myocardial Protection, Minimally Invasive Surgery
Myocardial Protection in Minimally Invasive Mitral Valve Surgery
Perfusion strategies and aortic clamping techniques for right mini-thoracotomy mitral valve (MV) surgery have evolved over time and remarkable short- and long-term results have been re-ported.
- Conditions
- Myocardial Protection, Minimally Invasive Surgery, Mitral Valve Prolapse
- Trial name
- NCT04231903
- Testing
- Aortic clamp
- Volunteers
- 116 people
- Sponsor
- University of Turin, Italy
Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding
Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction
This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction…
- Trial name
- PCAB-AMI (NCT07467213)
- Testing
- Zastaprazan, Proton Pump Inhibitors (PPI)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center
Rheumatic Valve Disease
Clinical Trial of Electro-Acupuncture Preconditioning in Patients Underwent Heart Valve Replacement Surgery
The purpose of this study is to investigate the protective effect of electro-acupuncture preconditioning in patients underwent cardiac surgery.
- Trial name
- NCT00732459
- Testing
- Electro-acupuncture preconditioning
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Myocardial Protection
Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass
The goal of this clinical trial is to evaluate whether the addition of adenosine to standard cardioplegia improves myocardial protection in adult patients undergoing on-pump cardiac surgery.
- Trial name
- ADENOCARDIO (NCT07426237)
- Testing
- Adenoseine
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Coronary Artery Bypass, Myocardial Ischemia
Glutamate for Metabolic Intervention in Coronary Surgery
The main purpose of this study is to determine whether intravenous glutamate infusion given in association with surgery for unstable coronary artery disease can protect the heart from myocardial injury, postoperative heart…
- Conditions
- Coronary Artery Bypass, Myocardial Ischemia, Myocardial Infarction, Coronary Artery Disease
- Trial name
- GLUTAMICS (NCT00489827)
- Testing
- Intravenous infusion of saline, Intravenous glutamate infusion
- Where
- 3 sites in Sweden
- Volunteers
- 865 people
- Sponsor
- University Hospital, Linkoeping
Complication of Extracorporeal Circulation, Complication of Coronary Artery Bypass Graft
Combined Use of a Novel Cardioplegic Formula With Myocardial Protection System (MPS)® Versus Cardioplexol ® in Isolated Coronary Artery Bypass Grafting (CABG) Using MiECC;
Combined use of a novel cardioplegic formula with MPS® (Myocardial protection system) versus Cardioplexol ® (colloid solution with Procaine, magnesium and potassium) in isolated CABG (coronary artery bypass grafting) using MiECC…
- Trial name
- MiECC (NCT03612388)
- Testing
- use of a cardioplegic formula in isolated CABG (coronary artery bypass grafting) using MiECC (Minimal extracorporeal circulation
- Where
- Switzerland
- Volunteers
- 211 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 2 Diabetes
Can Enhanced Glycemic Control in Type II Diabetics Improve Myocardial Protection During Coronary Artery Bypass Grafting?
The investigators have previously demonstrated that the administration of insulin in the form of an infusion with additional sugar and potassium may improve cardiovascular performance and reduce biochemical evidence of heart…
- Trial name
- GUIDE (NCT00899483)
- Testing
- Glucose potassium insulin solution
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham
ST-segment Elevation Myocardial Infarction
Distal Protection Device in ST-elevation Myocardial Infarction (STEMI)
The investigators examined the mechanism underlying the lack of benefit from distal protection and thrombus aspiration (DP-TA) in 126 patients with ST-elevation Myocardial Infarction (STEMI) in a prospective, randomized trial.
- Trial name
- NCT01384019
- Testing
- distal protection and thrombus aspiration (The GuardWire Plus (Medtronic Inc.)), c-PCI
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Bundang Hospital
Breast Cancer
Follow up Study of Crocin on Cardiac Function Protection in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy Based on Color Doppler Ultrasound Combined With Myocardial Zymogram
Foreign data show that: 1807 tumor patients were followed up for 7 years, 33% of them died of heart disease and 51% of them died of the tumor itself.
- Trial name
- NCT06187818
- Testing
- Crocin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Mei Zhang
Acute Coronary Syndrome
Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome
Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium.
- Trial name
- NCT01384656
- Testing
- GIK solution
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction
The purpose of this study is to evaluate the clinical, echocardiographic and angiographic outcome of distal protection in the infarct related coronary artery and implantation of drug eluting versus bare metal stents in patients…
- Trial name
- NCT00192868
- Testing
- Distal protection and drug eluting stent
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mitral Insufficiencies, Myocardial Protection
Comparison of Blood Cardioplegia and Custodiol
Thru the last 20 years it has been a discussion witch solution that gives the best myocardial protection during cardiac arrest by heart operations.
- Trial name
- NCT01941459
- Where
- Norway
- Volunteers
- 76 people
- Sponsor
- Ullevaal University Hospital
Aortic Valve Stenosis
Desflurane-induced Myocardial Protection
This study examines pharmacological preconditioning and post conditioning of desflurane by comparing cardiac troponin release in patients receiving either desflurane or propofol for the aortic valve surgery.
- Trial name
- NCT02019797
- Testing
- Desflurane
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Nobuyuki Katori
Ischemic Heart Disease, Valvular Heart Disease
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its…
- Conditions
- Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Diseases, Surgery-Complications
- Trial name
- THERMIC-4 (NCT05996120)
- Testing
- Hypothermic Cardiopulmonary Bypass, Normothermic Cardiopulmonary Bypass
- Where
- 11 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester
Myocardial Injury
Continuous Versus Repetitive Sevoflurane Administration for Preconditioning
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective…
- Trial name
- NCT00569816
- Testing
- Sevoflurane
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
Anesthesia
Volatile Anesthetics in Cardiac Protection
Patients undergoing stenting procedures, or cardiac or non-cardiac surgery could develop myocardial damage as testified by cardiac troponin release.
- Trial name
- NCT00364637
- Testing
- Sevoflurane (Volatile Anesthetic), Total intravenous anesthesia
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
Myocardial Ischemia, Cardiovascular Morbidity
The Effect of Peri-percutaneous Coronary Intervention Oxygenation on Myocardial Protection & Cardiovascular Fitness
Elective percutaneous coronary intervention (PCI) is often associated with myocardial necrosis evidenced by peri-procedural troponin release. This is a surrogate for subsequent cardiovascular events.
- Trial name
- NCT03256175
- Testing
- Percutaneous Coronary Intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Unstable Angina
PROTECT-TIMI 30 Trial
The primary purpose of this study was to compare the efficacy and safety of bivalirudin to eptifibatide (with or without unfractionated heparin or enoxaparin)given to subjects at high risk for heart attack and other…
- Trial name
- NCT00250471
- Testing
- Percutaneous Coronary Intervention (PCI)
- Volunteers
- 900 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Cardiac Surgical Procedures
Trial of Cyclosporine for Myocardial Protection During Open Heart Surgery
Administration of cyclosporine has been found to have a myocardial protective effect, improving post-operative cardiac function in patients undergoing percutaneous coronary interventions by diminishing infarct size.
- Trial name
- CYCLO1 (NCT00990795)
- Testing
- cyclosporine, saline solution
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Artery Disease
TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effect resulted in better cardiac…
- Trial name
- NCT00286585
- Testing
- Inhalational anesthetic, Intravenous anesthetic, propofol
- Where
- 3 sites in Switzerland
- Volunteers
- 385 people
- Sponsor
- University Hospital, Basel, Switzerland