Clinical trials: Myocardial Stunning
End Stage Renal Disease, Acute Kidney Injury
Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients
Hemodialysis is a therapy that filters waste, removes extra fluid and balances electrolytes. In hemodialysis, blood is removed from the body and filtered through a man-made membrane called a dialyzer, and then the filtered blood…
- Conditions
- End Stage Renal Disease, Acute Kidney Injury, Chronic Kidney Disease Stage 5
- Trial name
- ESRD (NCT03539861)
- Testing
- Hemodialysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Myocardial Stunning
Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
This study aims to confirm the safety and efficacy of diazoxide as an additive to hyperkalemic cardioplegia in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT04830982
- Testing
- IV Diazoxide
- Where
- United States
- Sponsor
- Johns Hopkins University
Myocardial Ischemia
Adenosine's Effect on STunning Resolution in Acute Myocardial Infarction
The aim of this study is to evaluate the effect of adenosine on the recovery of myocardial akinesia in ST-elevation myocardial infarction (STEMI).
- Trial name
- A-STAMI (NCT05014061)
- Testing
- Adenosine
- Sponsor
- Vastra Gotaland Region
Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
Myocardial stunning during chronic intermittent hemodialysis is a well-described phenomenon. Little case series of patients presenting myocardial stunning during renal replacement therapy for acute kidney injury in critically ill…
- Conditions
- Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency, Myocardial Stunning
- Trial name
- MS-CRRT (NCT05209230)
- Testing
- Continuous renal replacement therapy, Control group
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Coronary Arteriosclerosis, Heart Failure, Congestive
Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study)
Viability assessment remains a clinical challenge in patient with coronary artery disease and left ventricular dysfunction. Several imaging modalities are available for evaluating myocardial viability, based either on perfusion…
- Conditions
- Coronary Arteriosclerosis, Heart Failure, Congestive, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT00213746
- Where
- 8 sites in Belgium, France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Rouen
Myocardial Ischemia, Exercise
Exercise-induced Changes in Cardiac Function & Morphology
Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity.
- Conditions
- Myocardial Ischemia, Exercise, Myocardial Contraction, Myocardial Stunning
- Trial name
- NCT01179802
- Testing
- Strenuous Endurance exercise
- Where
- Switzerland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Myocardial Stunning
Stunning in Takotsubo Versus Acute Myocardial Infarction
The Stunning in Takotsubo versus Acute Myocardial Infarction (STAMI) Study Background: Acute myocardial stunning, herein defined as the reversible loss of myocardial function, occurs in both takotsubo syndrome (TS) and…
- Trial name
- STAMI (NCT04448639)
- Testing
- Echocardigraphy (ECHO), Bloodtest
- Where
- Sweden
- Volunteers
- 125 people
- Sponsor
- Vastra Gotaland Region
Myocardial Stunning, End-stage Renal Disease
Myocardial Stunning During Hemodialysis: Role of Dialyste Calcium Concentration
Chronic kidney disease (CKD) is linked to elevated mortality rate, and cardiovascular disease is the main cause related to this outcome.
- Trial name
- NCT02545426
- Testing
- Change the dialysate calcium concentration
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke, Ischemic, Cardiac Complication
Cardiomyocyte Injury Following Acute Ischemic Stroke
The primary goal of the CORONA-IS study is to characterize stroke-associated acute myocardial injury (elevated hs-cardiac troponin) using different diagnostic examinations in order get a better understanding of it's underlying…
- Trial name
- CORONA-IS (NCT03892226)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Myocardial Stunning, Transesophageal Echocardiography
Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation.
The rational of the study is the description of the evolution of systolic cardiac function post-stunning, evaluated by transesophageal minimally invasive echocardiography (hTEE).
- Conditions
- Myocardial Stunning, Transesophageal Echocardiography, Circulation, Extracorporeal
- Trial name
- Imacor-1 (NCT02770183)
- Testing
- Imacor
- Sponsor
- University Hospital, Geneva
Myocardial Infarct
STunning in Acute Myocardial Infarction - BAS
The objective of this trial is to examine the effect of immediate versus late administration of beta blockers, angiotensin converting enzyme inhibitors (ACEI), and sodium/glucose cotransporter 2 (SGLT2) inhibitors on…
- Trial name
- STAMI-BAS (NCT06562582)
- Testing
- Bisoprolol Oral Tablet, Ramipril Oral Product, Dapagliflozin Oral Product
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Myocardial Infarction, Myocardial Ischemia
Co-transplantation of Mesenchymal Stem Cell Derived Exosomes and Autologous Mitochondria for Patients Candidate for CABG Surgery
Heart failure (HF) and acute myocardial infarction that often follows are among the main causes of disability and death worldwide.
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Myocardial Stunning
- Trial name
- NCT05669144
- Testing
- mitochondria and MSC-derived exosomes
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Acute Myocardial Infarction, Hemorrhagic Myocardial Infarction
Novel Imaging Biomarkers for Mechanical Complications in Acute Myocardial Infarction
Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients.
- Conditions
- Acute Myocardial Infarction, Hemorrhagic Myocardial Infarction, Myocardial Stunning, Myocardial Hemorrhage
- Trial name
- MIRON-RUPTURE (NCT06450912)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rohan Dharmakumar
Myocardial Stunning
Intracoronary Administration of Levosimendan in Cardiac Surgery Patients
Incomplete recovery from ischemia causes stunned myocardium. Ischemia may be due to coronary artery disease or aortic cross-clamping during surgery. Stunning leads to myocardial dysfunction.
- Trial name
- NCT01500785
- Testing
- levosimendan, Vitamin B 12
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Tampere University Hospital
Coronary Artery Disease
STunning After Balloon Occlusion
The aim of this study is to examine in-depth cardiac function and morphology after short-term coronary occlusion by balloon inflation in patients with stable coronary artery disease (CAD) who undergo percutaneous coronary…
- Trial name
- STABO (NCT05023629)
- Testing
- Intracoronary balloon inflation
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Vastra Gotaland Region
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hibernation, Myocardial, Complete Occlusion of Coronary Artery
The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy)
The purpose of this study is to investigate the effect of percutaneous coronary intervention (PCI) on myocardial viability in coronary artery disease patients with single coronary total occlusion (CTO) lesions.
- Trial name
- NCT02767401
- Testing
- stenting or balloon expansion, aspirin, clopidogrel, ticagrelor, atorvastatin, rosuvastatin, betaloc
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Activity, Motor, Health Behavior
Mechanism for Exercise to Delay Cardiac Aging
The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle…
- Trial name
- NCT06031675
- Testing
- Vigorous intermittent lifestyle physical activity
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xiao-dong Zhuang
Hemodialysis
Intradialytic Exercise and Remote Ischaemic Preconditioning: a Cardioprotective Role ?
The aim of this clinical trial is to evaluate whether intermittent exercise and remote ischaemic preconditioning (rIPC) during haemodialysis (HD) can provide cardioprotection in adult patients (aged 20-79 years) undergoing HD for…
- Trial name
- EXPI-DIAL (NCT06856512)
- Testing
- Remote ischaemic preconditioning, Exercise, standard dialysis
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Avignon
Subarachnoid Hemorrhage, Myocardial Stunning
Serial Echocardiography After Subarachnoid Hemorrhage
There is increasing interest in myocardial abnormalities following central nervous system events, such as subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Myocardial Stunning, Takotsubo Cardiomyopathy
- Trial name
- SEAS (NCT00123695)
- Where
- 6 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Amsterdam UMC, location VUmc