Clinical trials: NSAIDs
NSAID (Non-Steroidal Anti-Inflammatory Drug), Lumbar Spine Fusion
NSAIDS Following Elective Lumbar Spine Fusion
This study will compare two common approaches to pain control after lumbar spinal fusion surgery. Participants will be randomly assigned to receive either standard pain medication alone or standard pain medication plus a short…
- Conditions
- NSAID (Non-Steroidal Anti-Inflammatory Drug), Lumbar Spine Fusion, Ketorolac, Postoperative Pain
- Trial name
- NCT07743606
- Testing
- Ketorolac, Naproxen, Standard Postoperative Pain Management
- Where
- United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
NSAID-Associated Gastropathy
Observational Study on Monitoring NSAID-Induced Gastropathy in Patients Using Magnetically-Controlled Capsule Gastroscopy
The objective of this study is to observe gastric mucosal injuries in NSAID and non-NSAID users with magnetically-controlled capsule gastroscopy, and explore the effects of NSAIDs on gastric mucosal damage.
- Trial name
- NCT06027060
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Spine Fusion, NSAID (Non-Steroidal Anti-Inflammatory Drug)
Pain Control After Lumbar Spine Fusion
The purpose of this randomized controlled trial is to determine if patients who receive non-steroidal anti-inflammatory medications (NSAIDs) following elective lumbar spinal fusion have increased rates of symptomatic nonunion…
- Conditions
- Spine Fusion, NSAID (Non-Steroidal Anti-Inflammatory Drug), Postoperative Pain
- Trial name
- NCT06484192
- Testing
- Naproxen 500 Mg, Ketorolac, OxyCODONE 5 mg Oral Tablet
- Where
- United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Non-steroidal Anti-inflammatory (NSAID), Analgesic
Bioequivalence Study to Compare Diclofenac Potassium Coated Tablet Versus Cataflam® 50 Coated Tablet
Randomized, four-way, four-period, fully-replicated, single oral dose, open-label, crossover, bioequivalence study to compare Diclofenac Potassium coated tablet (50 mg Diclofenac Potassium) versus Cataflam® 50 coated tablet (50…
- Conditions
- Non-steroidal Anti-inflammatory (NSAID), Analgesic, Antipyretic
- Trial name
- NCT05082662
- Testing
- Diclofenac Potassium coated tablet (50 mg Diclofenac Potassium), Cataflam® 50 coated tablet
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Renal Impairment, Gout
Evaluation of Colchicine and Nonsteroidal Anti-inflammatory Drug Combination Therapy and Renal Function in Gout Patients
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment…
- Conditions
- Renal Impairment, Gout, Colchicine Adverse Reaction, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT05006001
- Testing
- Colchicine and NSAID
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- En Chu Kong Hospital
Rheumatoid Arthritis, Osteoarthritis
Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy
The purpose of this study is to evaluate the efficacy of eupatilin on the prevention of gastroenteropathy in patients with NSAIDs and low dose steroid by comparing with rebamipide.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Other Musculoskeletal Disorder
- Trial name
- CEERS (NCT04885751)
- Testing
- Eupatilin, Rebamipide
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul National University Boramae Hospital
NSAID, Pain Management
Pre-emptive Analgesics in Orthodontic Treatment
This study is designed to determine if the preemptive use of a combination of acetaminophen and ibuprofen is more effective in reducing pain following orthodontic tooth movement when compared to the use of acetaminophen and…
- Trial name
- NCT03523988
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Washington
NSAID-associated Gastroduodenal Injury
A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601
This is a phase IV clinical study to evaluate the preventive effectiveness of NSAID-Associated Gastroduodenal Injury. The study is consisted of multi-center, doubleblind, active-controlled, stratified randomized, parallel group.
- Trial name
- NCT01912066
- Testing
- Stillen, Cytotec (reference drug), NSAID (Aceclofenac)
- Where
- South Korea
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
NSAID Related Gastric Irritation
Pilot Study of OXP001 and Brufen in Healthy Subjects
Oxford Pharmascience (the sponsor) is developing a new formulation of Ibuprofen (OXP001 - the study drug) which it is proposed will have less of the side effects than are currently reported with standard prescription strength…
- Trial name
- NCT02050958
- Testing
- OXP001, Ibuprofen
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Oxford Pharmascience Ltd
Platelet Dysfunction, Hemodilution
Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction
Study hypothesis: Desmopressin (DDAVP) can improve platelet function under influence of aspirin, hemodilution and mild hypothermia Mild hypothermia (34-35oC) is known to cause platelet dysfunction.
- Conditions
- Platelet Dysfunction, Hemodilution, Mild Hypothermia, NSAID
- Trial name
- NCT01382134
- Testing
- Aspirin, desmopressin
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
NSAID Induced Gastropathy
Randomized Double-Blind Clinical Trial of Rebamipide vs Esomeprazole in the Treatment of NSAID-induced Gastropathy
Primary objective: To determine the levels of malondialdehyde (MDA) and immunohistochemistry surrogate of inflammation in patients with NSAID-induced gastric mucosal injury treated with Rebamipide 3x a day vs Esomeprazole 40mg…
- Trial name
- NCT00641004
- Testing
- Rebamipide and Esomeprazole
- Where
- 4 sites in Philippines
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical, Inc., Philippines
Aspirin Hypersensitivity, NSAIDs Hypersensitivity
Nasal Provocation Test With Lysine-Acetylsalicylate (ASA) in Patients With Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Hypersensitivity
This study aims to compare the efficacy of nasal provocation test with Lysine-Acetylsalicylate in patients with history of NSAIDs hypersensitivity between mucocutaneous symptoms and respiratory symptoms and laboratory outcomes.
- Trial name
- NCT00815126
- Testing
- Lysine-ASA Nasal ProvocationTest
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University