Clinical trials: NSTEMI
Myocardial Infarction
Utility of Residual Syntax Score to Predict Outcome After Acute Myocardial Infarction
The aim of this study is to evaluate the utility of residual syntax score after PCI of the culprit vessel for patients with AMI (STEMI or NSTEMI) to predict 6-months clinical outcomes.
- Trial name
- NCT05392777
- Testing
- Residual syntax score
- Where
- Egypt
- Volunteers
- 490 people
- Sponsor
- Cairo University
Acute Myocardial Infarction, ST Elevation Myocardial Infarction
A Polypill for Secondary Prevention of Ischemic Heart Disease
Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. The most important aspect of CVD secondary prevention is adherence to guideline-indicated pharmacological therapy which globally remains…
- Conditions
- Acute Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
- Trial name
- NCT03541109
- Testing
- Polypill
- Where
- 2 sites in Iran
- Volunteers
- 1,200 people
- Sponsor
- Isfahan University of Medical Sciences
Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction (nSTEMI)
Prehospital Risk Stratification in Acute Coronary Syndromes
A feasibility study of prehospital echocardiographic examination and point-of-care troponin analysis, conducted by paramedics, in patients with suspected acute coronary syndrome.
- Trial name
- Pre-ACS (NCT04223986)
- Testing
- Ultrasound, Troponin- T quick test
- Where
- Norway
- Volunteers
- 126 people
- Sponsor
- Sorlandet Hospital HF
Stable Angina, Unstable Angina, NSTEMI
Evaluation of a Novel Non-Invasive Automated Fractional Flow Reserve Software System in Patients With Coronary Artery Disease
This retrospective study will evaluate the coronary angiograms of approximately 100 patients who have undergone invasive angiography and fractional flow reserve (FFR).
- Trial name
- NCT06183294
- Testing
- Collecting invasive FFR measurements.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Non ST Segment Elevation Acute Coronary Syndrome, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
Prasugrel Or Ticagrelor De-escalation in NSTE-ACS
The PROTEUS study is a randomized, cross-over, open-label, pharmacodynamic trial designed to compare the antiplatelet effect of reduced maintenance doses of prasugrel and ticagrelor in stable patients who recently had…
- Conditions
- Non ST Segment Elevation Acute Coronary Syndrome, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Unstable Angina
- Trial name
- PROTEUS (NCT05779059)
- Testing
- De-escalation to ticagrelor 60 mg at day 30, De-escalation to prasugrel 5 mg at day 30, Switch to ticagrelor 60 mg at day 45
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Acute Coronary Syndrome, NSTEMI - Non-ST Segment Elevation MI
Safety of Accelerated Rule-out Protocols in Patients Admitted With Chest Pain to a Crowded Chest Pain Unit (CPU)
The aim of this observational study registry is to assess the safety of a Non-ST-elevation myocardial infarction (STEMI) rapid rule-out strategy as proposed by European Guidelines in patients presenting with suspected acute…
- Trial name
- NCT03111862
- Testing
- NSTEMI Rule-Out according to hs-TnT
- Where
- Germany
- Volunteers
- 3,567 people
- Sponsor
- University Hospital Heidelberg
ST Elevation (STEMI) Myocardial Infarction, Non ST Elevation Myocardial Infarction (NSTEMI)
Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome
This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS).
- Conditions
- ST Elevation (STEMI) Myocardial Infarction, Non ST Elevation Myocardial Infarction (NSTEMI), Unstable Angina Pectoris
- Trial name
- NCT07366684
- Testing
- Percutaneous Coronary Intervention (PCI), Conservative Medical Therapy
- Where
- Serbia
- Volunteers
- 550 people
- Sponsor
- Clinical Center Niš
Unstable Angina or Non ST Elevated Myocardial Infarction
Downstream Versus Upstream Strategy for the Administration of P2Y12 Receptor Blockers
To evaluate the impact on outcomes of the currently accepted antithrombotic strategies based on the administration of newer P2Y12 receptor blockers (prasugrel and ticagrelor) in a population of non ST elevated ACS (NSTEACS)…
- Trial name
- DUBIUS (NCT02618837)
- Testing
- Downstream strategy, Upstream strategy
- Where
- Italy
- Volunteers
- 2,520 people
- Sponsor
- University of Padova
Heart Attack, Cardiac Event
Mobile Advanced Multi-Parameter Reporting in Patients Wearing a Novel Device: Utilization During Cardiac Rehabilitation
Advanced remote multi-parameter reporting during cardiac rehabilitation (MAPS-III). The primary purpose of this observational study is to collect baseline information of cardiac rehabilitation usage in the US for post-myocardial…
- Conditions
- Heart Attack, Cardiac Event, Cardiac Disease, Cardiac Infarct
- Trial name
- MAPS-III (NCT05957172)
- Testing
- ZOLL Arrhythmia Management System
- Sponsor
- Zoll Medical Corporation
Coronary Stenosis, Acute Coronary Syndrome
Systemic, Pancoronary and Local Coronary Vulnerability
The aim of the VIP study is to investigate the impact of vulnerability markers (inflammatory serum biomarkers for systemic vulnerability, coronary shear stress and vulnerability mapping for pancoronary vulnerability, and…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- VIP (NCT03606330)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Acute Myocardial Infarction
OPTical Coherence Tomography IMAging in Patients With Acute myocardiaL Infarction (OPTIMAL)
The purpose of the study is to investigate the clinical outcomes, safety and cost-effectiveness of intravascular OCT imaging in patients with acute myocardial infarction undergoing percutaneous coronary intervention (PCI).
- Trial name
- OPTIMAL (NCT03084991)
- Where
- 20 sites in China
- Volunteers
- 4,500 people
- Sponsor
- Harbin Medical University
Myocardial Infarction (MI), Dyslipidemias
Germany on Target Registry
Germany on Target Registry (DaZiR) is a prospective, Germany-wide patient registry designed to assess lipid management and low-density lipoprotein cholesterol ( LDL-C) target attainment in adults following acute myocardial…
- Trial name
- DaZiR (NCT07835282)
- Testing
- No study-assigned intervention
- Volunteers
- 10,000 people
- Sponsor
- Deutsche Gesellschaft für Lipidologie e. V. (DGFL) - Lipid-Liga
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Coronary Artery Disease, Acute Myocardial Infarction
Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI
Coronary flow reserve is an important measure of the integrity of the coronary microcirculation. Moreover, impaired coronary flow reserve is a predictor of future cardiovascular events and poor prognosis in patients after acute…
- Trial name
- REPAIR-ACS (NCT00711542)
- Testing
- autologous bone marrow-derived progenitor cells
- Where
- 2 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Acute Coronary Syndrome, STEMI
EKG Criteria and Identification of Acute Coronary Occlusion
The objective of this research study is to test the accuracy of preexisting criteria versus expert interpretation for the diagnosis of acute coronary occlusion (major heart attack due to a completely blocked blood vessel).
- Conditions
- Acute Coronary Syndrome, STEMI, STEMI - ST Elevation Myocardial Infarction, Acute Coronary Artery Thrombosis (Diagnosis)
- Trial name
- NCT03863327
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stony Brook University
Non-ST Elevation Myocardial Infarction (nSTEMI)
Risk-score Based ICU Triage
The investigators have created a new risk score that predicts whether initially stable patients with myocardial infarctions (heart attacks) will require intensive care while they are in the hospital.
- Trial name
- NCT03390270
- Testing
- Admission with NSTEMI
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Duke University
ST Elevated Myocardial Infarction, Sleep-Disordered Breathing
PRedictOrs, PHEnotypes and Timing of Obstructive Sleep Apnea in Acute Coronary Syndrome
Obstructive Sleep Apnea (OSA) is a well-known disorder of upper airways collapse during sleep time leading to oxygen desaturation and sleep fragmentation.
- Conditions
- ST Elevated Myocardial Infarction, Sleep-Disordered Breathing, Sleep, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- PROPHET-ACS (NCT04002739)
- Testing
- Polygraphy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiogenic Shock, Acute Myocardial Infarction
Can Escalation Reduce Acute Myocardial Infarction Mortality in Cardiogenic Shock
The CERAMICS study is designed to more clearly delineate the current care of acute myocardial infarction with cardiogenic shock (AMICS) patients who are treated with mechanical circulatory support (MCS) devices in the United…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- CERAMICS (NCT05800951)
- Where
- 17 sites in United States
- Volunteers
- 124 people
- Sponsor
- Henry Ford Health System
Coronary Artery Calcification, Ischemic Heart Disease
The Influence of Modifying Highly Calcified Coronary Lesions on Coronary Microcirculation
This is a prospective, single-center, three-arm study to evaluate the impact of severely calcified coronary lesions treatment on microvascular circulation.
- Conditions
- Coronary Artery Calcification, Ischemic Heart Disease, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Coronary Artery Disease
- Trial name
- NCT06507449
- Testing
- Lithotripsy, Orbital atherectomy, High-pressure non-compliant balloon
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Silesia
Unstable Angina, Non-ST-Elevation Myocardial Infarction
Diagnosis and Treatment of Acute Coronary Syndrome in the ED & the Impact of Rapid Bedside cTnl on Outcome.
The primary outcome in this study will be time to discharge for low-risk patients and therapeutic turnaround time for patients with NSTEMI or unstable angina.
- Trial name
- NCT00276432
- Testing
- iSTAT point of care analyzer
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Mayo Clinic