Clinical trials: Nail Diseases
Onychomycosis
A Study to Evaluate Efficacy and Safety of Four Posaconazole Regimens With Placebo and Terbinafine in the Treatment of Toenail Onychomycosis (Study P05082AM2)(COMPLETED)
The purpose of this study is to evaluate the efficacy, safety, and tolerability of oral administration of four dosing regimens of posaconazole relative to placebo and terbinafine, in the treatment of toenail onychomycosis.
- Trial name
- NCT00491764
- Testing
- SCH 56592, Terbinafine
- Volunteers
- 218 people
- Sponsor
- Merck Sharp & Dohme LLC
Paronychia, Epidermal Growth Factor Receptor Inhibitor
Efficacy and Safety of Kinesiology Tape Wrapping for Paronychia Induced by Epidermal Growth Factor Receptor Inhibitors
Epidermal growth factor receptor inhibitors(EGFRIs) have been applied in several common malignancies including advanced non-small cell lung cancer.
- Trial name
- NCT06411093
- Testing
- Kinesiology tape wrapping, Conventional treatment including silver nitrate cauterization
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Non-Metastatic Breast Cancer
Study of Chemotherapy-Induced Hair Changes and Alopecia, Skin Aging and Nail Changes in Women With Non-Metastatic Breast Cancer
The purpose of this study is to see how many patients develop hair, skin and nail changes due to cancer treatments. The investigators would like to study the clinical factors, genetic markers, and impact on patients'…
- Trial name
- NCT02530177
- Testing
- Clinical Assessments, Questionnaires, Saliva sample
- Where
- United States
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Onychomycosis of Toenail
To Evaluate Hallux Terbinafine Subungual Gel (HSG) in the Treatment of Onychomycosis
The key objective is to establish the efficacy, safety, tolerability, and pharmacokinetics of investigational drug Hallux Terbinafine Subungual Gel (HSG) administered over 44 weeks to patients with distal-lateral subungual…
- Trial name
- NCT05135910
- Testing
- Hallux Terbinafine Subungual Gel
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Hallux, Inc.
Onychomycosis
Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis
The purpose of this study is to determine if the iontophoretic application of terbinafine gel is safe and effective for teh treatment of distal subungual onychomycosis
- Trial name
- NCT01080079
- Testing
- Terbinafine Hydrochloride, Purified Water
- Where
- 9 sites in United States, Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Nitric BioTherapeutics, Inc
Onychomycosis
Alpha-bisabolol for Onychomycosis Treatment
Clinical, interventional, longitudinal study with random sampling. 60 patients will be divided into three groups, group A: control group, drug recommended by the Brazilian Society of Dermatology, group B: alpha bisabolol-based…
- Trial name
- NCT04940520
- Testing
- Drug recommended by the Brazilian Society of Dermatology, Alpha bisabolol product and laser, Alpha bisabolol product
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade do Vale do Sapucai
Fungal Infection, Onychomycosis
Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis
The randomized control trial study aimed to evaluate effectiveness and safety of amphotericin B in 30% DMSO solution comparing with 30% DMSO solution in NDMs onychomycosis treatment.
- Conditions
- Fungal Infection, Onychomycosis, Fungus, Nail
- Trial name
- amphotericin (NCT03814343)
- Testing
- amphotericin B in 30% DMSO, 30% DMSO
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Mahidol University
Healthy Volunteers
Skin Barrier Function in Women Using UV Nail Lamps
The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.
- Trial name
- NCT07700186
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Onychomycosis
Cumulative Irritation Test
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT00680095
- Testing
- AN2690, AN2690 Solution, Vehicle, Sodium Lauryl Sulfate, 0.5%
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pfizer
Ingrown Toe Nail, Flat Foot
Association of Ingrown Toenails With Flat Foot, Hallux Abducto Valgus and Hallux Limitus
This study will have implications for any healthcare professionals who routinely manage ingrown toenails. Although different conservative and surgical treatment have been suggested, the recurrent rate is still high ranging from…
- Conditions
- Ingrown Toe Nail, Flat Foot, Hallux Abductovalgus, Hallux Limitus
- Trial name
- NCT03843177
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Tibial Fractures, Pain
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs.
- Trial name
- NSAID (NCT07006675)
- Testing
- 600 mg Ibuprofen
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Onychomycosis
The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis
The purpose of this study is to evaluate the safety and efficacy of topical application of IDP-108 versus vehicle in treating patients with onychomycosis.
- Trial name
- NCT01007708
- Testing
- IDP-108, Vehicle
- Where
- 44 sites in United States, Canada
- Volunteers
- 780 people
- Sponsor
- Dow Pharmaceutical Sciences
Psoriasis, Psoriatic Arthritis
Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging
OptiSkin is now enrolling a new study to monitor nail changes in patients with nail psoriasis treated with Enbrel® (etanercept) with optical coherence tomography (OCT).
- Conditions
- Psoriasis, Psoriatic Arthritis, Psoriatic Nail
- Trial name
- NCT05135312
- Testing
- Etanercept, OCT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- OptiSkin Medical
Nail Diseases, Nail Abnormality
Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia
The purpose of this study is to assess the safety and efficacy of ropivacaine and hydrocodone for nail-procedure associated pain management.
- Trial name
- NCT05544734
- Testing
- Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Acetaminophen 1000mg, Ibuprofen 400 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Psoriasis, Psoriasis Vulgaris
A Pilot Study to Explore the Role of Gut Flora in Psoriasis
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Psoriasis.
- Conditions
- Psoriasis, Psoriasis Vulgaris, Psoriasis Universalis, Psoriasis Face
- Trial name
- NCT04099979
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Onychomycosis of Toenails
Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail
The purpose of this study is to determine whether AN2690 topical solution is a safe and effective treatment for onychomycosis of the toenail.
- Trial name
- NCT01270971
- Testing
- AN2690 Topical Solution, 5%, Solution Vehicle
- Where
- 27 sites in United States
- Volunteers
- 594 people
- Sponsor
- Pfizer
Paronychia
Effect of Zanthoxylum Nitidum Tincture for Paronychia Caused by Afatinib
This is a randomized control trial evaluating the efficacy of zanthoxylum nitidum tincture on preventing progression of paronychia caused by afatinib from grade 1 to grade 2/3.
- Trial name
- NCT03908892
- Testing
- zanthoxylum nitidum tincture, tetracycline ointment
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Psoriasis Circinata, Psoriatic Arthritis
Clinical and Dermoscopic Comparison of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriasis Patients' Nails
This study evaluates the fingernail findings of the rheumatoid arthritis, spondylopathy and psoriatic arthritis patient groups with the fingernails of psoriasis patients clinically and dermatoscopically and investigates the…
- Conditions
- Psoriasis Circinata, Psoriatic Arthritis, Rheumatoid Arthritis, Spondylarthropathies
- Trial name
- NCT04709354
- Testing
- Dermoscopic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Onychomycosis
Using Light Therapy to Treat Toe Nail Fungus
To see if four sessions of light therapy successfully treats nail fungus.
- Trial name
- NCT00771732
- Testing
- light therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nomir Medical Technologies
Subtalar Arthritis, Ankle Arthritis
Compression Nail for Tibiocalcaneal Arthrodesis
The purpose of this study is to determine the clinical efficacy of a novel dynamic compression intramedullary nail for tibiotalocalcaneal (TTC) arthrodesis
- Trial name
- NCT03780452
- Testing
- novel dynamic compression intramedullary nail
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Alabama at Birmingham