Clinical trials: Narcotic Use
Pregnancy Related, Narcotic Use
Determining the Effect of an "Alternate Recovery Protocol" Versus Current Standard of Care After Cesarean Section
This randomized controlled trial will compare two different approaches to patient recovery after cesarean section: the current standard of care versus an alternate management protocol.
- Trial name
- NCT03330119
- Testing
- Alternate Management, Control
- Where
- United States
- Volunteers
- 1,494 people, healthy volunteers welcome
- Sponsor
- Brest, Norman A., M.D.
Alcohol Drinking, Opioid Use
Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention
The goal of this treatment development project is to develop and pilot an adaptive mobile health (mHealth) intervention that targets the co-use of alcohol and opioids in young adults.
- Trial name
- NCT07663448
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brown University
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Stress Reaction, Opioid Use
Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.
Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human…
- Trial name
- NCT03248076
- Testing
- Fentanyl Citrate
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Papanicolaou Hospital
Opioid-Related Disorders, Opioid Dependence
An Innovative Intervention for OUD Treatment
The Bridge Device (BD) is a neuromodulator medical device that has been cleared by the FDA for Opioid Use Disorder (OUD) treatment.
- Conditions
- Opioid-Related Disorders, Opioid Dependence, Opioid Addiction, Opioid Withdrawal
- Trial name
- Bridge (NCT04325659)
- Testing
- Bridge Device, Lofexidine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Use, Kidney Diseases
Enhanced Recovery After Surgery in Kidney Transplant Donors
Enhanced recovery after surgery (ERAS) pathways are designed to optimize perioperative management, improving patient outcomes and satisfaction through multimodal techniques.
- Conditions
- Opioid Use, Kidney Diseases, Pain, Postoperative, Postoperative Complications
- Trial name
- NCT04110080
- Testing
- multimodal pain management, goal directed fluid management, preoperative carbohydrate loading
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Food Security
Novel Intervention to Improve Food Insecurity Among Individuals With Opioid Use Disorder
The adverse consequences of illicit opioid use (e.g., overdose, premature death) are the focus of intensive research efforts. However, other serious health problems among individuals with opioid use disorder (OUD) have received…
- Trial name
- NCT06374303
- Testing
- NE + Meal Delivery (NE+MD) intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Opiod Use Disorder
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Background: Opioids are medicines that control pain. But they are often misused, which can lead to illness and death. Opioids increase dopamine to the brain, which makes people feel good and often causes them to crave drugs…
- Trial name
- NCT03831971
- Testing
- ANS-6637
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Gynecologic Cancer, Endometrial Cancer
Mindfulness in Endometrial and Cervical Cancer
Patients with endometrial cancer who will be undergoing surgery or patients with cervical cancer who will be treated with chemoradiation will be randomized to utilize the Headspace smartphone application or not prior to their…
- Conditions
- Gynecologic Cancer, Endometrial Cancer, Cervical Cancer, Quality of Life
- Trial name
- MECCA (NCT04512144)
- Testing
- Headspace Smartphone Application
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Stimulant Use Disorder
Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment
This project will evaluate the ability of Mirtazapine (MZP), a pharmacologically unique medication with a growing body of evidence to support its efficacy and safety for the treatment of methamphetamine (MA) use among medication…
- Trial name
- MIRROM (NCT06323837)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington State University
Opioid-use Disorder, Opioid Use
The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis
Pregnant women with a history of opioid use disorder, chronic opioid use or those who are on medication assisted treatment will be randomly assigned to receive either a sub-fascial continuous infusion of bupivacaine or…
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Dependence, Opioid Abuse
- Trial name
- NCT04033562
- Testing
- Lidocaine patch, Ambu ACTion pump, 0.125% bupivacaine at 8cc/hr
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Opioid Use Disorder
Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study
This study proposes to examine the safety, tolerability, and pharmacokinetics (PK) of NYX-783 50 mg and 150 mg versus Placebo (PBO) in combination with acute Oxycodone 15 mg and 30 mg in an inpatient randomized, cross-over study…
- Trial name
- NCT05447286
- Testing
- NYX-783, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use
A Study to Evaluate Unintended Prolonged Opioid Use
Researchers are trying to better understand how people who are prescribed opioids for short-term use, go on to receive this type of medication on a longer-term basis.
- Trial name
- NCT04024397
- Where
- United States
- Volunteers
- 1,796 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Opioid Use
Opioid Consumption and Disposal After Shoulder Arthroplasty
Opioid medications are widely used after many orthopedic procedures and are routinely prescribed after shoulder replacement surgery.
- Trial name
- NCT05525975
- Testing
- Educational materials
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Brendan M. Patterson
Acute Pain
Evaluation of the Analgesic Efficacy of Multimodal Pain Control Regimens That Aim to Limit the Use of Narcotics in Cholecystectomy and Hernia Repairs
Subjects were patients of the five surgeons with Surgical Associates of Mansfield (SAM) who underwent an elective or urgent laparoscopic cholecystectomy; or elective or urgent laparoscopic or open hernia repair (inguinal…
- Trial name
- NCT06095453
- Testing
- Pain control regimens
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Pelvic Pain, Endometriosis
Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery
This will be a prospective, randomized, double blinded placebo-controlled study at Erlanger hospital. Eligible patients who provide consent will be randomized into one of two arms receiving continuous intra-peritoneal local…
- Conditions
- Pelvic Pain, Endometriosis, Pelvic Prolapse
- Trial name
- NCT04118777
- Testing
- Ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tennessee, Chattanooga
Total Knee Replacement, Post Operative Pain
Effect of Mindfulness on Pain After Total Knee Arthroplasty
This study will be a prospective randomized controlled trial evaluating the effectiveness of using Headspace before and after undergoing total knee replacement surgery.
- Conditions
- Total Knee Replacement, Post Operative Pain, Opioid Use
- Trial name
- NCT06118073
- Testing
- Headspace, Total Knee Replacement
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Opioid-use Disorder
Evaluation of Intranasal Naltrexone and Naloxone
This study will be to determine the pharmacokinetics of naltrexone and naloxone when administered via intranasal separately and in combination in healthy volunteers.
- Trial name
- NCT03851731
- Testing
- Naltrexone, Naloxone, Naltrexol
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)