Clinical trials: Nasal Bleeding
Hereditary Hemorrhagic Telangiectasia, Epistaxis Nosebleed
Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)
This study will investigate the effectiveness of oral low-dose tacrolimus for the treatment of recurrent nasal hemorrhage in HHT subjects.
- Trial name
- NCT04646356
- Testing
- Tacrolimus capsule (low-dose)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Epistaxis
Risk Factors of Epistaxis Recurrence in Adults
We study all patients admitted to the Emergency Department in the Institution between 01/2022 and 07/2023. The information about the recurrence of nose bleeding was searched on their medical file and by calling the patient to…
- Trial name
- FREA (NCT06657053)
- Where
- France
- Volunteers
- 145 people
- Sponsor
- University Hospital, Grenoble
Telangiectasia, Hereditary Hemorrhagic
Efficacy of Nintedanib for Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Patients
Patients affected by hereditary hemorrhagic telangiectasia (HHT) very often suffer from recurrent nosebleeds called epistaxis. There is no treatment currently available to reduce the frequency or severity of epistaxis.
- Trial name
- EPISTOP (NCT04976036)
- Testing
- Nintedanib
- Where
- 3 sites in France, Switzerland
- Volunteers
- 48 people
- Sponsor
- Dr. Romain Lazor
Intraoperative Bleeding
The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.
Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of…
- Trial name
- NCT06427707
- Testing
- Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Telangiectasia, Hereditary Hemorrhagic
Pomalidomide for the Treatment of Bleeding in HHT
This is a Phase II placebo-controlled double-blind study of pomalidomide in patients with hereditary hemorrhagic telangiectasia (HHT) with moderate to severe epistaxis who have anemia and/or require parenteral iron infusions or…
- Trial name
- PATH-HHT (NCT03910244)
- Testing
- Pomalidomide Oral Product
- Where
- 14 sites in United States
- Volunteers
- 145 people
- Sponsor
- The Cleveland Clinic
Epistaxis Nosebleed, Pharyngeal Bleeding
Guidewire Use in Nasotracheal Intubation
During nasotracheal intubation, nasopharyngeal trauma and associated bleeding may occur. The investigators think that some of this bleeding is due to trauma to the posterior wall of the nasopharynx.
- Trial name
- NCT05937516
- Testing
- Nasotracheal intubation with conventionally, Nasotracheal intubation with angled ETT using guidewire
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Hereditary Hemorrhagic Telangiectasia, Osler Weber Rendu Disease
Propranolol for Epistaxis in Hereditary Hemorrhagic Telangiectasia Patients
Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder of angiogenesis associated with disabling epistaxis. Management of these nose bleedings requires more effective treatment.
- Trial name
- EPERO (NCT04113187)
- Testing
- Propranolol treatment
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Bordeaux
Nasopharyngeal Carcinoma Patients Treated With Curative Radiotherapy
Massive Nasal Bleeding in Patients With NPC Received Curative RT
To investigate the incidence, predictive markers, and survival impact of massive nasal bleeding in nasopharyngeal carcinoma (NPC) patients who received curative radiotherapy (RT) with/without chemotherapy.
- Trial name
- NCT06348485
- Testing
- Patients without massive nasal bleeding, Patients with massive nasal bleeding
- Where
- Taiwan
- Volunteers
- 1,327 people
- Sponsor
- Taichung Veterans General Hospital
Epistaxis, Intubation
Nasal Ointment on Epistaxis of Nasotracheal Intubation in Children
Nasotracheal intubation is one of the anesthetic procedures required for oral surgery. It allows the surgeon easier access to the surgical site than the orthotracheal intubation.
- Trial name
- NCT04426409
- Testing
- tarivid ointment
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Ajou University School of Medicine
Epistaxis
The Roles of Hilotherapy in the Management of Epistaxis and Nasal Fractures
The Investigators aimed to assess primarily whether or not Hilotherapy masks are a tolerable treatment for the conservative management of epistaxis and nasal fractures.
- Trial name
- NCT04279288
- Testing
- Hilotherm mask
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Manchester University NHS Foundation Trust
Epistaxis Nosebleed
Coblation Versus Bipolar Diathermy in Management of Refractory Idiopathic Recurrent Anterior Epistaxis in Children.
The aim of this study is to compare the outcomes of coblation technique versus bipolar technique in management of RAE in children regarding the following: 1. Efficacy of each method to stop bleeding. 2. Technical feasibility. 3.
- Trial name
- NCT06651840
- Testing
- bipolar diathermy "Standard technique"., coblation technique.
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Nasal Obstruction, Rhinitis, Vasomotor
Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer
The purpose of this study is to learn whether nasal saline irrigation is beneficial to patients undergoing radiation therapy for oropharyngeal cancer.
- Conditions
- Nasal Obstruction, Rhinitis, Vasomotor, Epistaxis
- Trial name
- NCT02338102
- Testing
- Saline mixture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Lisa Shnayder
Upper GI Bleeding
Inhalation of Sevoflurane Versus Intravenous Midazolam,Ketamine,Propofol For Pediatrics Undergoing Upper GI Endoscopy
In the field of pediatric gastroenterology, upper gastrointestinal endoscopy has established itself as a diagnostic and therapeutic tool. In order to increase patient tolerance during this procedure, deep sedation is essential.
- Trial name
- NCT05474937
- Testing
- Sevoflurane Inhalation Solution, Midazolam, Ketamine and Propofol
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Zagazig University
HHT, Morbus Osler
Intranasal Submucosal Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
In a case series intranasal submucosal bevacizumab has been shown to reduce epistaxis in patients suffering from Hereditary Haemorrhagic Telangiectasia together with KTP Laser therapy.
- Conditions
- HHT, Morbus Osler, Epistaxis
- Trial name
- NCT01314274
- Testing
- Bevacizumab, NaCl
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University of Vienna
Computed Tomography-guided Nasotracheal Intubation, The Space Where the Tube Will be Passed in the Internal Nasal Valve Region
Computed Tomography-Guided Nasotracheal Intubation Procedure
Background: Nasotracheal intubation can lead to severe complications like epistaxis with excessive bleeding. The advancement difficulty of the tube faced during nasal intubation is one of the fundamental causes of this condition.
- Trial name
- NCT05525754
- Testing
- computed tomography-guided nasotracheal intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Ecchymosis
The Utility of Peri-operative Arnica Montana for Reduction of Ecchymosis in Rhinoplasty Surgery
Arnica montana is a homeopathic drug that is made in accordance with the official methods of the Homeopathic Pharmacopoeia of the United States (HPUS) and is commonly used by cosmetic surgeons throughout the world, although there…
- Trial name
- NCT01164644
- Testing
- Arnica montana
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wisconsin, Madison
Nasal Bleeding
Determining the Effects of Foley Catheter-assisted Nasal Intubation on Nasal Bleeding in Adult Patients
Nasal endotracheal intubation is a well-utilized and important endotracheal intubation route to allow good surgical access for operations involving the oral cavity.
- Trial name
- NCT05072392
- Testing
- Foley catheter
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Mount Sinai Hospital, Canada
Maxillofacial Injuries, Nasal Bleeding
Comparison Between Nasal and Oropharyngeal Bleeding in Video Laryngoscopy and Direct Laryngoscopy for Nasal Intubation
The objective of this study is to compare the effectiveness and safety of video laryngoscopy versus direct laryngoscopy for nasal intubation in patients with maxillofacial fractures regarding less bleeding to oral and nasal…
- Conditions
- Maxillofacial Injuries, Nasal Bleeding, Intubation Complication
- Trial name
- NCT06386757
- Testing
- Combined Video Laryngoscopy (VL) and Bougie, Combined Direct Laryngoscopy (DL) and Bougie
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Aswan University
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Prospective Pilot Study of Floseal for the Treatment of Anterior Epistaxis in Patients With (HHT)
Current management strategies for severe and recurrent epistaxis secondary to Hereditary hemorrhagic telangiectasia (HHT) include surgical procedures, and uncomfortable nasal packing, both of which are often only short-term…
- Trial name
- NCT02638012
- Testing
- Floseal, Packing
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Epistaxis, Anterior Ethmoid Artery
Cauterization of the Anterior Ethmoidal Artery by Transconjunctival Approach
The incidence of epistaxis varies from 7 to 14% in the general population and represents 30 per 100,000 emergency room admissions in adults. Most nasal bleeding is self-limiting without the need for specific medical treatment.
- Trial name
- AEA (NCT05663099)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France