Clinical trials: Nasal High Flow Therapy
Palliative Care, Breathlessness
Management of Dyspnea With High- Flow Nasal Therapy
Dyspnea in patients with incurable illness is a difficult symptom. Therefore, there is a need to identify new effective treatment modalities.
- Trial name
- HFNTpal (NCT07552935)
- Testing
- High-flow nasal therapy, Airflow directed to face by a fan
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Tampere University Hospital
Acute Respiratory Failure With Hypoxia, Oxygen Inhalation Therapy
Prehospital High-Flow Nasal Oxygen Therapy
The purpose of the present project is to compare High-Flow Nasal Oxygen therapy with Standard Oxygen therapy, initiated in the prehospital setting in patients with acute hypoxemia respiratory failure, in terms of oxygenation at…
- Conditions
- Acute Respiratory Failure With Hypoxia, Oxygen Inhalation Therapy, Prehospital Setting
- Trial name
- PRHOXY-1 (NCT03326830)
- Testing
- High-flow nasal oxygen, Standard oxygen therapy
- Where
- 2 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy
Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial
Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed.
- Conditions
- Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy, Noninvasive Ventilation, Continuous Positive Airway Pressure (CPAP)
- Trial name
- TRIPOD (NCT06795971)
- Testing
- Continuous Positive Airway Pressure, High-flow nasal oxygen, Non-invasive ventilation
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Southeast University, China
Chronic Obstructive Pulmonary Disease
Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
The investigators are looking at the effect of humidified nasal high-flow with oxygen (HNHF-O2) on air exchange during exacerbations of COPD.
- Trial name
- NCT03214458
- Testing
- Nasal high flow
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Temple University
Respiratory Insufficiency
High Flow Nasal Oxygen at Extubation for Adults Requiring a Breathing Tube for Treating Severe Breathing Difficulties
The goal of this feasibility study is to learn whether a new approach to breathing tube removal within the Intensive Care Unit is safe and acceptable to participants who require a breathing tube for the management of severe…
- Trial name
- Pre-SAFEx (NCT05904652)
- Testing
- Fisher and Paykel "HealthCare Airvo™ 3" high flow system, Conventional Oxygen Therapy
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- NHS Greater Glasgow and Clyde
Lung Diseases, Obstructive
Prospective Randomized Study of Nasal High Flow in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The main oxygen therapy to the patients with acute exacerbation of Chronic obstructive pulmonary disease, who are mild to moderate respiratory insufficiency (arterial blood gas analysis showed pH = 7.35, PO2 <…
- Trial name
- NCT02439333
- Testing
- Nasal high flow cannula (Fisher & Paykel Healthcare, Auckland, New Zealand), nasal catheter or Venturi mask
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Li Xuyan
Interstitial Lung Disease (ILD)
Nasal High-flow Oxygen Therapy During Acute Exercise in Fibrotic Interstitial Lung Disease
Hallmarks of fibrotic interstitial lung disease (f-ILD) include severe hypoxemia, dyspnea and exercise limitation. Although ambulatory oxygen (O2) therapy is widely prescribed, standard low-flow O2 systems (nasal prongs) fail to…
- Trial name
- PID-OXacute (NCT07129707)
- Testing
- Exercise testing
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Dieulefit Santé Centre de Réadaptation
Stable Chronic Hypercapnic Respiratory Failure
Home High-Flow Nasal Cannula vs. Noninvasive Ventilation for Stable Chronic Respiratory Failure
The goal of this clinical trial is to compare the effects of home high-flow nasal cannula (HFNC) therapy and noninvasive ventilation (NIV) in patients with stable chronic hypercapnic respiratory failure.
- Trial name
- NCT06872801
- Testing
- High-Flow Nasal Cannula, Noninvasive Ventilation
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Wonju Severance Christian Hospital
Post Abdominal Surgery
Comparison of HFNC and COT to Diaphragm Function of Post-upper Abdominal Surgery Patients
This study aims to compare diaphragm thickness, air lung distribution, and several clinical and laboratory parameters on post abdominal surgery patients with conventional oxygen therapy vs high-flow nasal cannula
- Trial name
- NCT04059614
- Testing
- HFNC; COT
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Respiratory Insufficiency
High Flow Nasal Oxygen Therapy in Pediatric Hypercapnic Respiratory Failure During Perioperative Stage
Humidified high flow nasal oxygen therapy decreases dilution of the inhaled oxygen and, by matching patient's peak flow, allows accurate delivery of the set FiO2 throughout the whole inspiratory phase.The purpose of this study is…
- Trial name
- NCT03534960
- Testing
- High Flow Nasal Oxygen Therapy, Nasal CPAP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Ventilator Weaning
Physiologic Effects of High-flow Nasal Cannula Versus Standard Oxygen Therapy Postextubation in Critically Ill Patients
High-flow nasal cannula (HFNC) is a rather novel system to provide oxygen therapy, which provides flows up to 60 liters/minute (LPM) of heated and humidified gas through nasal prongs.
- Trial name
- NCT04711759
- Testing
- High flow nasal cannula, Standard oxygen therapy
- Where
- Chile
- Volunteers
- 26 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Interstitial Lung Disease, Acute Respiratory Failure
NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in…
- Trial name
- IRAPIDPhysio (NCT06182956)
- Testing
- Noninvasive mechanical ventilation, Nasal high-flow oxygen therapy, Continuous positive airway pressure
- Where
- France
- Volunteers
- 18 people
- Sponsor
- ADIR Association
Respiratory Failure
Effects of Treatment With High Flow Nasal Cannulas on Respiratory Pattern and Work of Breathing Among Healthy Subjects
This study evaluates the work of breathing among healthy subjects under various conditions of treatment with high flow nasal cannulas. Ten subjects will be included.
- Trial name
- HDWOBSS (NCT02495675)
- Testing
- High flow nasal cannulas, Conventional flow via nasal prongs
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Laval University
Severe Sepsis
High Flow Nasal Cannula in Severe Sepsis
Severe sepsis leads a high morbidity and mortality by causing organ damage at distance. The treatment relies on early antibiotic therapy and hemodynamic resuscitation.
- Trial name
- OPTISEPSIS (NCT03334227)
- Testing
- High-Flow nasal cannula (HFNC)
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Respiratory Distress
Virtual Reality Application During High Flow Nasal Oxygen Therapy in Children Effect on Anxiety Levels
Determination of the effect of virtual reality goggles used during high-flow oxygen therapy on child anxiety in children
- Trial name
- NCT06886828
- Testing
- Virtual reality goggles during HFNC, HFNC oxygen therapy with routine service application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uskudar University
Respiratory Failure
Effects of Treatment With High Flow Nasal Cannulas on Respiratory Pattern and Work of Breathing Among Patients.
This study evaluates the work of breathing among patients under various conditions of treatment with high flow nasal cannulas. Sixteen spontaneously breathing patients with respiratory failure (hypercapnic or hypoxemic) will be…
- Trial name
- HDWOBPT (NCT02494154)
- Testing
- Airvo 2; Ficher and Paykel HealthCare, Oxygen delivery via conventional nasal mask
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Laval University
Respiratory Distress Syndrome, Adult, Acute Hypoxemic Respiratory Failure
Weaning From Nasal High Flow Therapy
Nasal high flow is widely used in critically ill patients admitted to the intensive care unit (ICU) for acute hypoxemic respiratory failure.
- Conditions
- Respiratory Distress Syndrome, Adult, Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome, Weaning Failure
- Trial name
- NCT05210881
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Hôpital Louis Mourier
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea
High Flow Nasal Cannula Therapy for Childhood OSA
The main objective of this study is to evaluate the efficacy of high-flow nasal cannula (HFNC) therapy in children with OSA. Children and adolescents aged 6 to 18 years old with a diagnosis of moderate-to-severe OSA requiring…
- Trial name
- NCT03933800
- Testing
- High flow nasal cannula, Continuous positive airway pressure
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Coronavirus Infection, Pneumonia, Viral
HFNC Treatment in COVID-19 Pneumonia
coronavirus disease 2019 related pneumonia is causing acute respiratory failure and this is the most common reason for ICU admission. We have several different way for respiratory support.
- Conditions
- Coronavirus Infection, Pneumonia, Viral, Acute Respiratory Failure
- Trial name
- NCT04424836
- Testing
- high flow nasal cannula device
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital