Clinical trials: Nasal Polyp
Nasal Polyps, Asthma
Assessment of Oral and Nasal Breathing With Sensors Analyzing Algorithm
The goal of this observational study is to learn about the agreement between sensors analyzing algorithm and body plethysmography in measuring oral and nasal breathing in healthy adults, and in patients with chronic…
- Conditions
- Nasal Polyps, Asthma, COPD, Allergic Rhinitis
- Trial name
- NCT05869071
- Testing
- Sensor analyzing software (own development), Body plethysmograph
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Nasal Polyps
Mint Tea for the Treatment of Nasal Polyps
The purpose of this study is to evaluate the safety and efficacy of a new treatment for nasal polyps as compared to placebo (an inactive substance). The treatment involved is mint tea high in rosmarinic acid.
- Trial name
- NCT00465543
- Testing
- Mint tea high in rosmarinic acid, Mint tea low in rosmarinic acid
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
COVID-19, Temporomandibular Disorder
Temporomandibular Joint and COVID-19
There is evidence that CV-19 is associated with joint symptoms, but there are no specific data on the temporomandibular joint (TMJ). It is also known that the systemic health status can impact the immune system.
- Conditions
- COVID-19, Temporomandibular Disorder, ASA Triad
- Trial name
- NCT05077189
- Testing
- Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) scale
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Nasal Polyps, Chronic Sinusitis
Wound Healing After Endoscopic Sinus Surgery
This study aims to determine the effect of Thymoquinone (0.5%) and olive oil ointment on Wound healing after Endoscopic sinus surgery.
- Trial name
- NCT06070311
- Testing
- Thymoquinone (0.5%) and Olive oil ointment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Smell Loss, Chronic Rhinosinusitis (CRS)
Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss.
- Trial name
- CIPOD (NCT07681973)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Nasal Polyps
Retrospective Study for Recurrent Nasal Polyposis
A retrospective study for patients with recurrent nasal polypi operated at Otorhinolaryngology Department, Sohag University Hospital will be carried out.
- Trial name
- NCT04804488
- Testing
- nasal polyp surgery
- Where
- Egypt
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Sohag University
Healthy, Chronic Rhinosinusitis With Nasal Polyps
Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis
The purpose of this study is to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06817024 in healthy volunteers, in participants with chronic rhinosinusitis, with nasal polyps and in participants with…
- Conditions
- Healthy, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis
- Trial name
- NCT02743871
- Testing
- PF-06817024
- Where
- 20 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hyperactivity, Allergic Rhinitis Due to House Dust Mite
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Allergic Rhinitis Due to House Dust Mite, Chronic Rhinosinusitis With Nasal Polyps
- Trial name
- NCT04286542
- Testing
- Cold, dry air
- Where
- Belgium
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Chronic Rhinosinusitis (Diagnosis), Nasal Polyposis
Mometasone vs Budesonide in CRS With Polyposis
The principal objective is to compare the use of mometasone nasal spray to budesonide irrigations in patients suffering from CRSwNP who have never been operated.
- Trial name
- NCT03323866
- Testing
- Budesonide 0.5 MG/ML, Mometasone nasal spray
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Rhinosinusitis (Diagnosis)
Viral and Epigenetic Influences in CRSwNP
Background/rationale While multiple disorders feature a Type 2 (T2) inflammation, triggers for T2 remains unknown. In Chronic Rhinosinusitis with Nasal Polyposis CRSwNP), a classic Type 2 disorder, dysfunction of the epithelial…
- Trial name
- NCT05857228
- Testing
- Endoscopic sinus surgery (ESS)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Nasal Polyps, Sinusitis
Dupixent Study for Alternate Administration
Investigators will investigate an alternate Dupilumab administration schedule in patients with recurrent chronic rhinosinusitis with nasal polyposis, who have a history of full endoscopic sinus surgery and are on appropriate…
- Conditions
- Nasal Polyps, Sinusitis, Chronic Disease
- Trial name
- NCT06750471
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Patients With Nasal Polyps
Compare the Effects of Fluticasone Furoate Nasal Spray vs Placebo in Patients With Nasal Polypoid Disease
Fluticasone furoate is being studied to determine whether treatment with a topical nasal steroid, in patients with existing nasal polyps , can not only improve symptoms but also suppress the recurrence of clinically significant…
- Trial name
- NCT01013701
- Testing
- fluticasone furoate
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Rhinosinusitis With Nasal Polyps
The Role of Budesonide Intrapolyp Injection in the Management of Type 2 Chronic Rhinosinusitis
To investigate the usage of budesonide as an agent in the injection of Type 2 chronic rhinosinusitis with nasal polyps
- Trial name
- NCT05931744
- Testing
- Budesonide, Prednisone, Saline
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Chronic Rhinosinusitis (CRS) with and Without Nasal Polyps
Correlation of Preoperative Indices (serum Vit D, Calcium, Phosphorus, FAR, PLR, SII) on Intraoperative Bleeding in CRS
The purpose of this observational study was to examine whether preoperative indicators correlate with intraoperative bleeding to facilitate control of intraoperative bleeding.
- Trial name
- NCT06737198
- Testing
- without interventios.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Chronic Rhinosinusitis With Nasal Polyps
th2 Modulation CRSwNP
Chronic rhinosinusitis (CRS) is a condition of persistent sinonasal mucosal inflammation which affects 11.9% of the US population.
- Trial name
- NCT06107101
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Paul's Sinus Centre
Asthma Persistent, Asthma, Allergic
Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma
The aim of this study is to determine and compare serum cytokine levels of six different severe asthma inflammatory phenotypes differentiated by their atopy, peripheral eosinophilia and/or chronic rhinosinusitis and/or nasal…
- Conditions
- Asthma Persistent, Asthma, Allergic, Eosinophilic Asthma, Chronic Rhinosinusitis (Diagnosis)
- Trial name
- NCT03563521
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Chronic Sinusitis, Rhinosinusitis
Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study
This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis.
- Conditions
- Chronic Sinusitis, Rhinosinusitis, Nasal Polyps
- Trial name
- NCT00841802
- Testing
- Prednisone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Nasal Polyps, Sinusitis
Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps
Endoscopic sinus surgery (ESS) has become the standard of care for patients suffering of chronic rhinosinusitis with nasal polyposis (CRSwP) who have failed medical therapy.
- Trial name
- NCT02855931
- Testing
- Middle turbinate resection
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Allergic Rhinitis, Non-Allergic Rhinitis
Detection and Use of Nasal Nitrous Oxide and the Electronic Nose
Introduction: Rhinitis, sinonasal polyposis (SP) and asthma are diseases whose pathogenesis is based on inflammation. This will determine the presence of disease, its evolution and its treatment.
- Conditions
- Allergic Rhinitis, Non-Allergic Rhinitis, Nasal Polyps
- Trial name
- EPONA (NCT02476929)
- Testing
- Nasal nitrous oxide, Electronic nose
- Where
- Spain
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau