Clinical trials: Nasal Polyps
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Nasal Polyps
Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis With Nasal Polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease of the sinonasal mucosa whose metabolic and immunologic mechanisms are incompletely understood.
- Trial name
- NCT07860411
- Testing
- Nasal polyp tissue and blood sampling, Nasal mucosa and blood sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Harran University
Nasal Obstruction, Septal Defect
Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?
The objective of this study is to compare the effectiveness of batten grafts plus septoplasty and turbinate reduction (intervention arm) compared to septoplasty and turbinate reduction alone (control arm), both in terms of…
- Conditions
- Nasal Obstruction, Septal Defect, Allergic Rhinitis, Nasal Polyps
- Trial name
- NCT05287841
- Testing
- Batten batten graft, Septoplasty, Inferior Turbinate Reduction
- Where
- 3 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics
This project will focus on rehabilitation of olfactory dysfunction in patients with chronic rhinosinusitis with polyps given biological treatment based on functional magnetic resonance imaging.
- Conditions
- Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07819162
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid Asthma
This study is a randomized, double-Blind, placebo-controlled, Single and Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in…
- Trial name
- NCT07436949
- Testing
- BBT002
- Where
- 12 sites in China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bambusa Therapeutics
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Smell Loss, Chronic Rhinosinusitis (CRS)
Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss.
- Trial name
- CIPOD (NCT07681973)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS).
- Trial name
- IMMUNODOR (NCT06776042)
- Testing
- Nasal brushing of the olfactory cleft, Smell testing
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Rhinosinusitis With Nasal Polyps, Severe Eosinophilic Asthma
Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma
The goal of this observational study is to learn about clinical and functional outcomes in patients with Chronic rhinosinusitis with nasal polyps and comorbid Severe Eosinophilic Asthma and patients with Chronic rhinosinusitis…
- Conditions
- Chronic Rhinosinusitis With Nasal Polyps, Severe Eosinophilic Asthma, Chronic Rhinosinusitis Without Nasal Polyps
- Trial name
- MepoRiNaPAs (NCT06069310)
- Testing
- Mepolizumab 100 MG
- Where
- 2 sites in Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Chronic Obstructive Pulmonary Disease (COPD), Asthma Patients
Evaluation of Nasal Biomarkers for Objective Assessment of Disease Severity in Respiratory Disorders
This research study is an observational, single site study quantifying expression of biomarkers of respiratory disease in nasal fluid using the ABEL microsampler device.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma Patients, Asthma and Rhinitis, Asthmatic Patients
- Trial name
- ENBOARD (NCT06661252)
- Testing
- ABEL microsampler device
- Where
- Australia
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Diag-Nose Medical Pty Ltd
Chronic Asthma
Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry
Primary objective To study the stability of different phenotypes and endotypes of asthma at 3, 5, and 7 years of follow-up and - in MEGA COHORT and in patients on biologic treatment Secondary objective(s) To study biomarkers…
- Trial name
- MEGA (NCT06163807)
- Testing
- Antiasthmatic
- Where
- 8 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Nasal Polyps, Aspirin-exacerbated Respiratory Disease
Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant…
- Trial name
- RECAP-5 (NCT05672030)
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Rhinosinusitis Without Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps
Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS).
Chronic rhinosinusitis (CRS) is a disease associated with impaired quality of life and substantial societal costs. Much is still uncertain regarding the underlying etiology of the disease.
- Trial name
- NCT07184684
- Testing
- Sinonasal microbiome transplant procedure.
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Region Skane
Nasal Polyps, Sinusitis
Dupixent Study for Alternate Administration
Investigators will investigate an alternate Dupilumab administration schedule in patients with recurrent chronic rhinosinusitis with nasal polyposis, who have a history of full endoscopic sinus surgery and are on appropriate…
- Conditions
- Nasal Polyps, Sinusitis, Chronic Disease
- Trial name
- NCT06750471
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Chronic Rhinosinusitis (CRS) with and Without Nasal Polyps
Correlation of Preoperative Indices (serum Vit D, Calcium, Phosphorus, FAR, PLR, SII) on Intraoperative Bleeding in CRS
The purpose of this observational study was to examine whether preoperative indicators correlate with intraoperative bleeding to facilitate control of intraoperative bleeding.
- Trial name
- NCT06737198
- Testing
- without interventios.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Chronic Rhinosinusitis With Nasal Polyps
Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
The study will be conducted to identify factors predicting the response of chronic rhinosinusitis with nasal polyps ( CRSwNP) to oral corticosteroids.
- Trial name
- NCT06459622
- Testing
- Serum IL_25 and eosinophils in nasal polyp tisuee
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Katrina Atef Habashy
Chronic Rhinosinusitis With Nasal Polyps
th2 Modulation CRSwNP
Chronic rhinosinusitis (CRS) is a condition of persistent sinonasal mucosal inflammation which affects 11.9% of the US population.
- Trial name
- NCT06107101
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Paul's Sinus Centre
Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected…
- Trial name
- NCT06129552
- Testing
- Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Correlation Between the Microbiome and Type 2 Inflammatory Diseases of CRSwNP
Nasal microorganisms, exfoliated cells, nasal secretions, fetal microorganisms and blood were collected from patients with chronic sinusitis with nasal polyps before medication.
- Trial name
- NCT06231004
- Testing
- glucocorticosteroid and surgery
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Nasal Polyps
Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is indicated in diseases such as chronic sinusitis refractory to medical treatment, nasal polyposis, mass lesions in the nasal cavity.
- Trial name
- NCT02484859
- Testing
- Remifentanil, Tramadol, Metoprolol
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Nasal Polyps, Asthma
Assessment of Oral and Nasal Breathing With Sensors Analyzing Algorithm
The goal of this observational study is to learn about the agreement between sensors analyzing algorithm and body plethysmography in measuring oral and nasal breathing in healthy adults, and in patients with chronic…
- Conditions
- Nasal Polyps, Asthma, COPD, Allergic Rhinitis
- Trial name
- NCT05869071
- Testing
- Sensor analyzing software (own development), Body plethysmograph
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital