Clinical trials: Nasolacrimal Duct Obstruction
Dacryocystitis, Dacryocystitis; Chronic
Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other
The goal of this observational study is to investigate etiology and pathogenesis of nasolacrimal duct obstruction and dacryocystitis in different adult clinic groups.
- Conditions
- Dacryocystitis, Dacryocystitis; Chronic, Dacryocystorhinostomy, Epiphora
- Trial name
- NCT06810089
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Uludag University
Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases
Closed Dacryointubation vs Bicanalicular Intubation for Proximal Tear Duct Obstruction
In Mexico, upper lacrimal duct obstruction (ULDO) is a common pathology, and the standard surgical treatment is closed dracryointubation.
- Conditions
- Lacrimal Duct Obstruction, Lacrimal Apparatus Diseases, Lacrimal Stenosis, Lacrimal Elimination
- Trial name
- DICvsBIcanal (NCT06428266)
- Testing
- Bicanalicular intubation, Closed dacryointubation
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Congenital Nasolacrimal Duct Obstruction
Recanalization of Congenital Nasolacrimal Duct Obstruction by Endodiathermy Probe and Intubation Versus Intubation Only
The purpose of the current work is to assess the efficiency and success rate of endodiathermy probe followed by intubation in children more than 2 years compared to the success rate of intubation (as a standard method) which…
- Trial name
- NCT04148170
- Testing
- Endodiathermy Probe and Intubation Versus Intubation
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patient With Nasolacrimal Duct Obstruction, External Dacryocystorhinostomy Operation
Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation
Bleeding is one of the important complications during Dacryocystorhinostomy, which dissatisfy ophthalmic surgeon, reduces surgical field visualization, and increases the duration of surgery Thus, the management of this…
- Trial name
- NCT05241054
- Testing
- Bupivacaine, Nitroglycerine, Propofol
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Mansoura University
Lacrimal Duct Obstruction
Clinical Study of Lacrimal Drainage Obstruction Diseases Using Dacryoendoscopy
Nasolacrimal duct obstruction (NLDO) can manifest as epiphora or recurrent infections with mucopurulent discharge and may even cause social embarrassment.
- Trial name
- NCT05999058
- Testing
- Dacryoendoscopic-assisted laser dacryoplasty with silicone intubation
- Where
- China
- Volunteers
- 522 people
- Sponsor
- Tianjin Eye Hospital
Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions
Color Doppler Ultrasound in Lacrimal Sac Space-occupying Lesions
Dacryocystitis and nasolacrimal duct obstruction are the main common causes of epiphora. Dacryocystorhinostomy (DCR) is a widely used and effective treatment for dacryocystitis and nasolacrimal duct obstruction.
- Conditions
- Dacryocystitis; Chronic, Lacrimal Sac Space-occupying Lesions, Color Doppler Ultrasound, Computed Tomography
- Trial name
- NCT05500950
- Testing
- CDU and CT-DCG or CT examination
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Wenzhou Medical University
Epiphora, Dacryostenosis
Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT05663684
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Nasolacrimal Duct Obstruction
A Comparison of Endonasal Dacryocystorhinostomy With and Without Silicone Tubes
Aim of study is to investigate whether the use of silicone tubes in endonasal DCR surgery increases the success rate and / or complication rate compared to surgery without tubes.
- Trial name
- NCT00784992
- Testing
- Endonasal dacryocystorhinostomy
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Nasolacrimal Duct Obstruction
Study of Surgical Procedures for Treatment of Persistent Nasolacrimal Duct Obstruction in Children < 4 Years Old
The purpose of this study is: To report the success proportions for the treatment of persistent nasolacrimal duct obstruction for three surgical procedures: balloon catheter dilation, nasolacrimal intubation, and simple probing.
- Trial name
- NLD2 (NCT00315315)
- Testing
- Nasolacrimal balloon catheter dilation, Nasolacrimal intubation, Nasolacrimal duct probing
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- Jaeb Center for Health Research
Nasolacrimal Duct Obstruction, Dacryocystorhinostomy
Amniotic Membrane for Dacryocystorhinostomy
This study aims to compare the success rate of external dacryocystorhinostomy with and without amniotic membranes in patients with nasolacrimal duct obstruction.
- Trial name
- AMDCRex (NCT06226181)
- Testing
- Dacryocystorhinostomy and amniotic membrane, Conventional dacryocystorhinostomy
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Congenital Nasolacrimal Duct Obstruction
Endoscopy Assisted Probing Versus Simple Probing in Primary Congenital Nasolacrimal Duct Obstruction
The aim of this study is to compare results of endoscopy assisted nasolacrimal probing with the standard simple probing in cases with congenital nasolacrimal duct obstruction .
- Trial name
- Non (NCT03242681)
- Testing
- Endoscopy Assisted Probing procedure
- Where
- Iran
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Epiphora, Nasolacrimal Duct Obstruction
Lacrimal Drainage Resistance Study
Epiphora, or uncontrolled tearing of the eyes, represents a common presenting complaint of patients seen by ophthalmologists. Epiphora may be due to non-obstructive causes, such as tear hypersecretion or functional tear pump…
- Conditions
- Epiphora, Nasolacrimal Duct Obstruction, Canalicular Stenosis, Functional Tear Pump Failure
- Trial name
- LDRS (NCT01766232)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Primary Acquired Nasolacrimal Duct Obstruction
Comparative Outcomes of Four Versus Two Balloon Inflation Points in Dacryoplasty for Primary Acquired Nasolacrimal Duct Obstruction
Primary acquired nasolacrimal duct obstruction
- Trial name
- NCT07225244
- Testing
- 2 point balloon dacryoplasty with LacriCATH®, 4 point balloon dacryoplasty with LacriCATH®
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia
Improving the Follow up Rate for Pediatric Patients
Follow-up of pediatric patients is important for their regular ocular morbidity monitoring, especially for amblyopia management.
- Conditions
- CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia, Conjunctivitis, Eye Injuries
- Trial name
- NCT04837534
- Testing
- Counseling group, SMS and phone call reminder group
- Where
- Nepal
- Volunteers
- 264 people
- Sponsor
- Seva Foundation
Epiphora, Dacryocystorhinostomy
SLlt Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction
This project aims to test whether a newly designed lacrimal stent - the SlitStent - when placed into the lacrimal system in the standard fashion following a DCR surgery, will provide good symptomatic relief for epiphora and be…
- Trial name
- SLINDO (NCT03705000)
- Testing
- Slit Stent II, BIKA for DCR
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Gardner
Congenital Nasolacrimal Duct Obstruction
Safety and Efficacy Study of Besivance™ for Treatment of Congenital Nasolacrimal Duct Obstruction in Children
The goal of the study is to evaluate the application of Besivance™ (besifloxacin ophthalmic suspension, 0.6%) to treat congenital nasolacrimal duct obstruction in children.
- Trial name
- NCT01431170
- Testing
- Besivance Treatment Group, Polytrim Treatment Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Rutgers, The State University of New Jersey
Glaucoma, Ocular Hypertension
Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP
Glaucoma is the most frequent cause of irreversible \& preventable blindness worldwide, affecting about 2% of the world's population in people over 40.
- Conditions
- Glaucoma, Ocular Hypertension, IOP
- Trial name
- EXP-LP (NCT03318146)
- Testing
- drug delivery system, XALATAN®
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shaare Zedek Medical Center
Nasolacrimal Duct Obstruction
The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study
The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge. The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery.
- Trial name
- NCT06346561
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Acquired Nasolacrimal Duct Obstruction
Evaluation of Different Methods of Posterior Flap Management in External Dacryocystorhinostomy
The aim of DCR is to form a new, mucosa-lined pathway between the lacrimal sac and the nasal cavity where tears can bypass a lacrimal obstruction and drain directly in the nose.
- Trial name
- NCT06530264
- Testing
- DCR
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Eye Diseases, Lacrimal Duct Obstruction
Nasolacrimal Duct Obstruction
1.1 Background Obstructions of the lacrimal drainage system can be differentiated based on anatomical location or severity. But also, differentiating between congenital and acquired nasolacrimal duct obstruction (NLDO) is…
- Trial name
- NCT04931186
- Testing
- retrospective analyis
- Where
- Austria
- Volunteers
- 625 people
- Sponsor
- Medical University of Vienna