Clinical trials: Natriuretic Peptide Brain
Heart Failure, Congestive
Catheterization Laboratory Study: Acute Responses in Diastolic Heart Failure
1. Research question: What is the response of the heart's pumping function to changes in heart chamber pressures? 2. Experimental design: Patients undergoing routine cardiac catheterization will be studied.
- Trial name
- NCT00204945
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Heart Decompensation
A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure
The purpose of this study is to find out if nesiritide (a human B-type natriuretic peptide/hBNP) as compared to placebo, plus the usual treatment for acute decompensated heart failure, helps to improve breathing difficulties…
- Trial name
- NCT00475852
- Testing
- Nesiritide
- Where
- 328 sites in United States, Argentina and 26 more
- Volunteers
- 7,141 people
- Sponsor
- Scios, Inc.
Pulmonary Hypertension
Natrecor for Pulmonary Hypertension in Lung Transplants
This study seeks to demonstrate that Natrecor® (nesiritide) is safe and effective and has a favorable hemodynamic profile in lung transplant recipients that will allow for the avoidance of inhaled nitric oxide (iNO) use.
- Trial name
- NCT00205426
- Testing
- Natrecor
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Wisconsin, Madison
Chronic Right-Sided Heart Failure, Pulmonary Arterial Hypertension
Spironolactone Therapy in Chronic Stable Right HF Trial
The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right heart function and remodeling in…
- Conditions
- Chronic Right-Sided Heart Failure, Pulmonary Arterial Hypertension, Pulmonary Hypertension, Primary, 2, Pulmonary Hypertension, Primary, 3
- Trial name
- STAR-HF (NCT03344159)
- Testing
- Spironolactone, PET/CT Scan: Two PET scans using 1. C-11 HED and 2. N-13 Ammonia or rubidium-82, Cardiac MRI (Gadolinium enhanced)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Ottawa Heart Institute Research Corporation
IUGR, Fetal Growth Retardation
Cardiac Displacement From Third Trimester to Early Childhood
The aim is to increase awareness of the relationship between (IUGR) and cardiac function in the foetus, the development of cardiac function over time after delivery and what significance a possible early disturbed myocardial…
- Conditions
- IUGR, Fetal Growth Retardation, Intrauterine Growth Restriction
- Trial name
- CADETTE (NCT02583763)
- Testing
- Echocardiography, Blood sample
- Where
- 2 sites in Sweden
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Cardiovascular Disease, Acute Renal Failure
The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure
The purpose of this trial is to study the use of nesiritide in thoracic aneurysm repair to prevent acute renal failure. The study hypothesis: Nesiritide, given prophylactically prior to surgery may prevent acute renal failure…
- Conditions
- Cardiovascular Disease, Acute Renal Failure, Death
- Trial name
- NCT00110201
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Ejaz, Abulate A, MD
Hypertension Stage 1
B-type Natriuretic Peptide (BNP) in Human Hypertension
The investigators working hypothesis is that human hypertension is in part due to a derangement in the endocrine function of the heart - a primary or secondary mechanism - resulting in a relative deficiency of the natriuretic…
- Trial name
- NCT00953472
- Testing
- brain natriuretic peptide, no-added salt diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Cardiac Ischemia, Thoracic Cancer
Perioperative Troponin I and NT Pro-BNP in Lung Resection
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery.
- Conditions
- Cardiac Ischemia, Thoracic Cancer, Complication,Postoperative
- Trial name
- NCT04749212
- Testing
- serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)
- Where
- Spain
- Volunteers
- 475 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Heart Failure, Congestive, Dyspnea
Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF
Heart failure (HF) is a disease that is caused by a reduced heart muscle function. Reduced heart muscle function can occur as a consequence of reduced pumping activity from a weak heart muscle or because of a stiff heart muscle.
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00505791
- Testing
- Nesiritide
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Heart Failure With Preserved Ejection Fraction
Exploration of Dyspnea at Non-high Brain Natriuretic Peptide (BNP)
Patients with unexplained stress dyspnea ( ≥ stage 2 NYHA), no significant underlying lung disease, with an ejection fraction > 50%, normal resting filling pressures, NTproBNP < 220 pg/ml in < 75 years, and < 450 pg/ml in ≥ 75…
- Trial name
- NEON HFpEF (NCT03550235)
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
A Study to Evaluate the Effects of EECP in Patients With Heart Failure
The aims of this proposal are to investigate whether external enhanced counterpulsation (EECP) can facilitate heart failure (HF) patient weaning from intravenous infusion of positive inotropic agent, and thus decrease the length…
- Trial name
- NCT03857022
- Testing
- Enhanced External Counterpulsa
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Renal Insufficiency, Chronic
Is Hemodialysis Associated With Cardiac Markers Change?
Hemodialysis (HD) triggers recurrent and cumulative ischemic insults to the brain and the heart. Cooled dialysate may have a protective effect on major organs and improve hemodynamic tolerability of dialysis.
- Trial name
- NCT04929366
- Testing
- Hypothermic dialysis followed with routine dialysis, Routine dialysis followed with hypothermic dialysis
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Ziv Hospital
Congestive Heart Failure, Renal Dysfunction
Study of Low Dose Nesiritide With or Without Sildenafil in Congestive Heart Failure Patients With Renal Dysfunction
The purpose of the study is to show that low dose recombinant BNP coupled with phosphodiesterase V inhibition will improve renal dysfunction and promote relief of volume overload in patinets with acute decompensated heart failure…
- Trial name
- BNP+PDEVI (NCT00818701)
- Testing
- low dose Nesiritide, nesiritide, Sildenafil
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Healthy
Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes.
- Trial name
- BNP/Appetite (NCT01375153)
- Testing
- BNP, 0.9% NaCl
- Where
- 2 sites in Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Heart Failure, Arrhythmias
Comparison Study of BNP and Thoracic Impedance Measurements on Arrhythmias
It is hypothesized that elevated BNP level correlate with an elevated thoracic impedance/fluid index as measured separately by CRT-D devices and external impedance cardiography.
- Trial name
- NCT00580255
- Where
- United States
- Sponsor
- University of California, Davis
Congestive Heart Failure, Renal Insufficiency
Nesiritide Infusion for the Treatment of Decompensated Heart Failure and Renal Dysfunction
The researchers hypothesize that the addition of nesiritide to standard therapy will prevent worsening of renal function in patients admitted to the hospital with decompensated heart failure and renal dysfunction relative to…
- Trial name
- NCT00119691
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Brigham and Women's Hospital
Diagnostic Tests
AQT90 FLEX NTproBNP (N-terminal Pro-brain Natriuretic Peptide) 2 Test Kit - Clinical Evaluation Study Protocol - China
To validate the NTproBNP2 Test Kit by using the test results of the predicate device as a reference. It will be demonstrated that the investigational product (NTproBNP2 Test Kit) and the predicate are equivalent.
- Trial name
- NCT07208877
- Volunteers
- 120 people
- Sponsor
- Radiometer Medical ApS
Hypertension
Nesiritide in Resistant Hypertension
Hypothesis: If the use of B-type natriuretic peptide (BNP) is proven to be effective in controlling high blood pressure, it may lead to a reduction of standard therapy and improved cardiovascular and kidney protection.
- Trial name
- NCT01514357
- Testing
- Nesiritide (BNP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- John C Burnett
Heart Failure, Congestive
A Safety Study Comparing Natrecor (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive Heart Failure
The purpose of this study is to compare the effects on heart rate and ventricular arrhythmias (irregular heart beats) of two doses of Natrecor® (a recombinant form of the natural human peptide normally secreted by the heart in…
- Trial name
- NCT00270400
- Testing
- nesiritide
- Volunteers
- 255 people
- Sponsor
- Scios, Inc.
Breast Cancer
Kinetics of Troponin and BNP in Breast Cancer Chemotherapy With Adriamycin and Trastuzumab
This pilot study involves very frequent monitoring of breast cancer patient blood levels of hs-cTnT Troponin and n-t-BNP (Brain Natriuretic Peptide) before and after initiation of chemotherapy with either adriamycin or…
- Trial name
- NCT01771549
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Mayo Clinic