Clinical trials: Natriuretic Peptides
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Cardiovascular Diseases
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood.
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease
- Trial name
- NCT04055428
- Testing
- Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity, Cardiovascular Diseases
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death.
- Conditions
- Obesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood Pressure
- Trial name
- PRECISION-BP (NCT04971720)
- Testing
- Sacubitril-Valsartan 49 Mg-51 Mg Oral Tablet, Valsartan 80 mg Oral Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Natriuretic Peptides, Cardiovascular Diseases
CARBON: UAB Cardiovascular Research Biobank
The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time.
- Conditions
- Natriuretic Peptides, Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- CARBON (NCT05067231)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Natriuretic Peptides, Obesity
The Diurnal Rhythm in Natriuretic Peptide Levels
The purpose of the study to assess the diurnal rhythm in natriuretic peptide levels and its temporal relationship with nocturnal blood pressure in obese and African-American individuals as compared with lean and white individuals.
- Conditions
- Natriuretic Peptides, Obesity, Nocturnal Blood Pressure
- Trial name
- NCT03834168
- Testing
- standardized Study Diet
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy, Natriuretic Peptides
Racial Differences in the Natriuretic Peptide Response to Glucose Challenge
The purpose of the study is to discover any racial dissimilarity in the response of Natriuretic peptide (NP) system to acute metabolic influences such as a high carbohydrate challenge
- Conditions
- Healthy, Natriuretic Peptides, Metabolic Syndrome
- Trial name
- NCT03072602
- Testing
- Study diet, Glucose Challenge
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Polycystic Ovary Syndrome, c Type Natriuretic Peptide
Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women
Recent studies have shown that C natriuretic peptide is produced from granulosa cells, increasing cumulative guanosine monophosphate (cGMP) production by affecting cumulus cells through natriuretic peptide receptors.
- Conditions
- Polycystic Ovary Syndrome, c Type Natriuretic Peptide, Menstrual Irregularity, Hyperandrogenism
- Trial name
- CNP (NCT04006171)
- Testing
- C type natriuretic peptide
- Where
- Cyprus
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Troponin, Natriuretic Peptide, Brain
Myocardial Injury is Not Related to Training Levels Among Recreational Participants in the Silicon Valley Marathon
To determine if pre-race training effects heart damage induced by marathon running.
- Conditions
- Troponin, Natriuretic Peptide, Brain, Exercise, Echocardiography
- Trial name
- NCT00560040
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Stanford University