Clinical trials: Nausea and Vomiting, Postoperative
Prolonged QTc Interval
Granisetron Versus Ondansetron: Comparative Effects on ECG, QTc
Postoperative nausea and vomiting [PONV] are common and distressing symptoms after surgery performed under general anaesthesia. 5HT3 antagonists are routinely used for prevention as well as treatment of PONV.
- Trial name
- NCT01352130
- Testing
- Ondansetron, Granisetron
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Tata Memorial Hospital
PONV
Phase IIIb Study of APD421 in Combination as PONV Prophylaxis
A comparison of the efficacy of APD421 and placebo when combined with a standard anti-emetic in the prevention of PONV in patients at high risk of Post-operative Nausea and Vomiting (PONV).
- Trial name
- NCT02337062
- Testing
- APD421
- Where
- 25 sites in United States, France and 1 more
- Volunteers
- 1,147 people
- Sponsor
- Acacia Pharma Ltd
Menstrual Cycle, Optic Nerve Sheath Diameter
Effects of Menstrual Cycle on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery
This observational study aims to evaluate the effect of menstrual cycle phase on optic nerve sheath diameter (ONSD) in women undergoing elective laparoscopic gynecologic surgery.
- Conditions
- Menstrual Cycle, Optic Nerve Sheath Diameter, Postoperative Nausea and Vomiting
- Trial name
- NCT07539831
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Konya City Hospital
Patient-Controlled Analgesia
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery.
- Trial name
- POPCORN (NCT06186141)
- Testing
- Morphine, Oxycodone
- Where
- Australia
- Volunteers
- 690 people
- Sponsor
- Murdoch Childrens Research Institute
Perioperative Body Temperature, Postoperative Nausea and Vomiting
The Effect of Intraoperative Body Temperature on Postoperative Nausea and Vomiting in Pediatric Patients
The aim of our study was to investigate the effects of changes in body temperature in the perioperative period on postoperative nausea and vomiting.
- Trial name
- NCT04155931
- Testing
- body temperature measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Lidocaine, Dexmedetomidine
Effect of Lidocaine Plus Dexmedetomidine Infusion on PONV
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Lidocaine, Dexmedetomidine, Nausea and Vomiting, Postoperative
- Trial name
- NCT03788018
- Testing
- lidocaine and dexmedetomidine IV, saline IV
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xu Siqi
Postoperative Nausea and Vomiting, Nausea and Vomiting, Postoperative
Study Of An NK-1 Anti-Emetic Medication For The Prevention Of Post-Operative Nausea And Vomiting In Female Patients
The purpose of this study is to determine the effectiveness of this medication in preventing nausea and vomiting in female patients at risk for post-operative nausea and vomiting (PONV).
- Trial name
- NCT00600990
- Testing
- GW597599
- Where
- 55 sites in United States, Australia and 10 more
- Volunteers
- 624 people
- Sponsor
- GlaxoSmithKline
PONV
Penehyclidine for PONV Prophylaxis After Strabismus Surgery
Patients scheduled for elective strabismus surgery under general anesthesia in the First Affiliated Hospital of Nanjing Medical University will be included in this study.
- Trial name
- NCT04054479
- Testing
- Penehyclidine, normal saline
- Where
- China
- Volunteers
- 228 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Postoperative Nausea and Vomiting
Use of Baxter Animated Retching Faces (BARF) Scale to Measure Nausea in Children Who Speak Spanish
Pediatric research in the management of nausea has been limited by the absence of a reliable method to quantify the intensity of this subjective symptom.
- Trial name
- NCT02007109
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Postoperative Nausea and Vomiting, Postoperative Pain
Acupuncture for Postoperative Nausea, Vomiting and Pain in Children: The Implication of Parental Attitudes
Postoperative nausea and vomiting (PONV) remain a significant challenge in our practice. However, pharmaceutical prophylaxis is only partially effective and can imply unpleasant adverse effects.
- Trial name
- NCT01729052
- Testing
- Acupuncture
- Volunteers
- 282 people
- Sponsor
- University of Tromso
Cerebral Tumor
The Effects of Gabapentin Premedication on Neurosurgery
The study is to observe the effects of gabapentin premedication on postoperative pain,vomiting and nausea in patients undergoing neurosurgery. 100 neurosurgical patients are randomized into groups gabapentin(GG) or placebo(GP).
- Trial name
- NCT02306278
- Testing
- gabapentin, vitamin capsules
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Capital Medical University
Pain, Postoperative, Nausea, Postoperative
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Hip Arthroscopy
The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after hip arthroscopy.
- Conditions
- Pain, Postoperative, Nausea, Postoperative, Opioid Use
- Trial name
- NCT04610398
- Testing
- Dexamethasone 4mg, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Intrathecal Dexmedetomidine
Intrathecal Dexmedetomidine to Decrease Postoperative Nausea and Vomiting and Shivering.
Background: Highly selective α-2 agonist dexmedetomidine in increasingly used as an intrathecal adjuvant for caesarean section performed under subarachnoid block.
- Trial name
- NCT05892705
- Testing
- Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Emergence Delirium
The PREVENT AGITATION Trial II - Children ≤1 Year
Emergence agitation is a clinical condition in which the child experiences a variety of behavioural disturbances including crying, thrashing, and disorientation during early awakening from anaesthesia.
- Trial name
- NCT05091242
- Testing
- Clonidine, Sodium chloride
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 336 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Nausea and Vomiting
Risk Factors Analysis for Clinical Important Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is a distressing and common complication after surgery. The concept of clinical important PONV (CI-PONV) assesses the impact of PONV on patient-reported outcomes.
- Trial name
- NCT06445920
- Testing
- No Intervention
- Where
- China
- Volunteers
- 1,154 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Postoperative Nausea and Vomiting
Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting.
Postoperative nausea and vomiting (PONV) are common and continue to be persistent problems following general anesthesia. Intranasal lidocaine has been used for the treatment of migraine.
- Trial name
- NCT04810494
- Testing
- 2% Lidocaine HCl topical solution, 0.9% Sodium chloride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Postoperative Nausea and Vomiting, Hysterectomy
Effect of SmtO2 Guided Care on PONV (iMODIPONV)
This randomized controlled trial is to investigate if SmtO2-guided management on top of the usual care, compared with the usual care only, during laparoscopic hysterectomy significantly reduces the incidence of PONV.
- Conditions
- Postoperative Nausea and Vomiting, Hysterectomy, Tissue Oxygenation, Cardiac Output Management
- Trial name
- iMODIPONV (NCT03641625)
- Testing
- Muscular tissue oxygen saturation guided care
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Yale University
Postoperative Pain, Postoperative Nausea and Vomiting
Effects of Methylprednisolone After Total Knee Arthroplasty
The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Sleeping Quality, Fatigue
- Trial name
- NCT00968578
- Testing
- Methylprednisolone
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Postoperative Nausea and Vomiting
Famotidine Versus Placebo in Emergency Pediatric Surgery As a Risk to Postoperative Nausea and Vomiting
The aim of this study is to evaluate the difference of the gastric volume by quantitative measurements of gastric antrum preoperatively and postoperatively by using 5mg famotidine versus placebo as a risk factor of PONV.
- Trial name
- NCT06211088
- Testing
- famotidine plus10ml normal saline, 10ml normal saline
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital