Clinical trials: Nebulization
Asthma in Children
Budesonide/Formoterol Turbuhaler® Versus Terbutaline Nebulization as Reliever Therapy in Children With Moderate Asthma Exacerbation
Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as the controller and the quick relief therapy termed single maintenance and reliever therapy (SMART) is a potential therapeutic regimen for the…
- Trial name
- ASTHMAFAST (NCT04705727)
- Testing
- Budesonide Formoterol Drug Combination, nebulisation of terbutaline
- Where
- 8 sites in France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Asthma in Children
Efficacy and Safety of Continuous Versus Intermittent Nebulization of Salbutamol in Acute Severe Asthma in Children Under 12 Years of Age
Asthma affects around 260 million people globally, causing around 0.5 million deaths annually. Pediatric asthma remains a major global public health challenge, significantly affecting the quality of life for many children.
- Trial name
- NCT06754631
- Testing
- Continuous Nebulization of Salbutamol, Intermittent Nebulization of Salbutamol
- Where
- 2 sites in Pakistan
- Volunteers
- 120 people
- Sponsor
- Muhammad Aamir Latif
Awake Fiberoptic Intubation
Atomization Vs. Nebulization for Airway Topicalization During Awake Nasotracheal Fiberoptic Intubation
Intubation of difficult airway is a challenge for anesthetist. There many causes of difficult airway, and previous studies concluded that awake fiber-optic intubation (AFOI) is the gold standard for the management of these…
- Trial name
- NCT05320731
- Testing
- Nebulization with lidocaine, Atomization with lidocaine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Zagazig University
Ventilator Associated Pneumonia
Pharmacokinetics of Nebulized Amikacin in Patients With Pneumonia Undergoing Mechanical Ventilation
Inclusion of patients undergoing mechanical ventilation and presenting a pneumonia in order to determine serum pharmacokinetics of nebulized amikacin.
- Trial name
- DARTAGNAN (NCT00861315)
- Testing
- Nebulized amikacin, Intravenous amikacin
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Association Pour La Promotion A Tours De La Reanimation Medicale
Asthma
Radioaerosol Pulmonary Deposition During Asthma Exacerbation Through Noninvasive Ventilation
Despite the physiologic and clinical effects provided by coupling nebulization with noninvasive ventilation in asthma exacerbation, there are few and controversial studies reported in the literature.
- Trial name
- NV (NCT01012050)
- Testing
- NV, NEB group
- Where
- Brazil
- Volunteers
- 39 people
- Sponsor
- Universidade Federal de Pernambuco
Nebulization, Dexmedetomidine
Efficacy of Nebulized Dexmedetomidine on Blunting Hemodynamic Changes During Intubation and Pneumoperitoneum in Morbid Obese Patients During Laparoscopic Bariatric Surgery
This study aims to evaluate the effect of preoperative dexmedetomidine nebulization on blunting hemodynamic response for laryngoscope, intubation, pneumoperitoneum, and opioid consumption in morbidly obese patients undergoing…
- Conditions
- Nebulization, Dexmedetomidine, Hemodynamic Changes, Intubation
- Trial name
- NCT07054138
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Non-small Cell Lung Cancer Stage I, Non-small Cell Lung Cancer Stage II
Nebulized AER101 in Pre-op NSCLC
The primary objective of this pilot study is to determine if AER101 can decrease glycolysis in non-small cell lung cancer (NSCLC).
- Trial name
- AER101 (NCT07631299)
- Testing
- AER101
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Oklahoma
Asthma
A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control
Albuterol (salbutamol) is a widely used asthma medication but is associated with undesirable side effects such as shakiness and increased heart rate.
- Trial name
- NCT00385359
- Testing
- aerosol drug deposition strategies, Albuterol
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Asthma
Phase1, Placebo-Controlled, Randomized, Double-blind, Single-ascending Dose Study in Healthy Subjects.
To evaluate the safety and tolerability of S-1226 composed of perflubron with ascending doses of carbon dioxide (4%, 8%, and 12% CO2) administered over 2 minute nebulisation to healthy subjects.
- Trial name
- NCT02616770
- Testing
- S1226 (4%), Saline (for 4%), S1226(8%)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SolAeroMed Inc.
Cystic Fibrosis
Evaluation of the Timing of the Nebulization Related to the Physiotherapy Session
The purpose of this study is to determine the optimal time for the nebulization depending on the respiratory physiotherapy session in cystic fibrosis patients.
- Trial name
- NCT02201082
- Testing
- Airway clearance technique, Amikacin nebulization
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Asthma
Dose-Ranging Study of LQ036 Single-Domain Antibody Nebulization Solution in Poorly Controlled Asthma
What is the goal of this study? The goal of this clinical trial is to find out whether the study drug LQ036 (a nebulized solution taken by inhaling through a nebulizer) works to improve lung function and asthma control in people…
- Trial name
- NCT07589439
- Testing
- LQ036
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Shanghai Novamab Biopharmaceuticals Co., Ltd.
Nebulization, Intravenous
Nebulized Versus Intravenous Tranexamic Acid on Surgical Field Quality in Patients Undergoing Endoscopic Sinus Surgeries
Intraoperative bleeding is one of the vital problems for anesthesiologists and surgeons, during endoscopic nasal surgery; where the surgical field is very limited and surrounded by vital structures.
- Conditions
- Nebulization, Intravenous, Surgical Field, Endoscopic Sinus Surgeries
- Trial name
- NCT06777966
- Testing
- nebulized tranexamic acid, intravenous tranexamic acid
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Tracheostomized Patients
Influence of Tracheostomy on Lung Deposition in Spontaneously Breathing Patient
To compare lung deposition of amikacin in two settings: spontaneously breathing through a tracheostomy cannula and through the mouth.
- Trial name
- NCT01882595
- Testing
- Nebulization through the tracheostomy, Nebulization through the mouth
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypoxemic Respiratory Failure, Airway Obstruction
In Line Aerosol Nebulization With High Flow
The objective of ILAN is to assess the safety, feasibility and bronchodilator efficacy of in-line bronchodilator nebulizer delivery with VMN via HFNC system in hypoxemic respiratory failure patients treated with bronchodilators…
- Trial name
- ILAN (NCT05880836)
- Testing
- nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen, standard jet nebulization (SJN) with face mask
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Post Operative Sore Throat
Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study
Sore throat includes specific symptoms such as dysphagia, dysphonia, hoarseness, continuous throat pain, and pharyngeal dryness.
- Trial name
- NCT05975346
- Testing
- Ketamine, saline nebulization
- Volunteers
- 80 people
- Sponsor
- Sohag University
Asthma
Salbutamol in the Pediatric Emergencies: Nebulization Estimated Via AerogeN or Jet
Controlled trial of nebulized salbutamol using jet nebulizer or vibrating mesh technology in children presenting with acute moderate to severe asthma.
- Trial name
- SIBILANT (NCT03042065)
- Testing
- vibrating Mesh nebulizer, jet nebulizer
- Volunteers
- 60 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
High Flow Nasal Cannula
Evaluation on the Efficacy of Bronchodilator Nebulization Via High Flow Nasal Cannula
High-humidity nasal cannula (HFNC) has been shown to be effective in improving oxygenation and avoiding intubation in multiple randomized control trials, it is also suitable and feasible for long term use.
- Trial name
- NCT03091504
- Testing
- High flow nasal cannula, Albuterol Sulfate
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Asthma
Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma
The purpose of this study is to investigate the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency.
- Trial name
- NCT01584726
- Testing
- Magnesium Sulfate
- Where
- 2 sites in Qatar
- Volunteers
- 400 people
- Sponsor
- Hamad Medical Corporation
Excessive Airway Secretions
Impact of Continuous Isotonic Saline Nebulisation Combined With Heated Humidification on the Rheology of Bronchial Secretions.
This study aims to evaluate whether adding a continuous mist of saltwater (saline nebulization) to warmed, humidified air can improve the properties of mucus in the lungs compared to humidified air alone.
- Trial name
- PHYSIORHEO (NCT07617142)
- Testing
- Saline Nebulization, Heated humidification
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Lung Diseases
Intrapleural Nebulization of Bupivacain to Reduce Postoperative Pain
Thoracic surgery is now common and as other surgeries evolution of minimally invasive techniques is employed. Video-assisted thoracic surgery (VATS) produces little scar but may produce severe pain that may affect the pulmonary…
- Trial name
- NCT05282251
- Testing
- Intrapleural bupivacine nebulization, Intravenous paracetamol and ketorolac
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University