Clinical trials: Neck
Neck Pain, Musculoskeletal Diseases
Effectiveness of Scapula Mobilization on Mechanosensitivity of Upper Limb Neural Test 1 in Mechanical Neck Pain
Between 45% and 70% of the general population suffers neck pain at some point in their lives, making it one of the most frequent reasons for taking sick leave.
- Trial name
- ULNT1 (NCT04168476)
- Testing
- Interscapular muscle release or scapular mobilization technique as described by Travell and Simons., Calcaneus abduction and adduction mobilization technique
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aitor Vaquero Garrido
Oral Potentially Malignant Lesions, Oral Cancer
Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)
The study is designed to measure serum and salivary CYFRA21-1 levels using enzyme linked immunosorbent assay (ELISA) in patients with oral malignancy, oral potentially malignant lesions, and control subjects to evaluate the…
- Trial name
- CYFRA21-1 (NCT03686020)
- Testing
- Enzyme Linked Immunosorbent assay (ELISA)
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Head and Neck Cancer
An Exploratory, Open Label, Single Center Study of [F-18]HX4
[F-18]HX4 is being developed as a diagnostic radiopharmaceutical for PET imaging. This trial is looking at the safety of [F-18]HX4.
- Trial name
- HX4 (NCT00606424)
- Testing
- 20 mCi dose for a 50 kg individual of [F-18]HX4
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Siemens Molecular Imaging
Second Trimester Abortion
Cervical Preparation With Mifepristone Prior to Osmotic Dilators
The investigators plan to study the role of mifepristone prior to the placement of cervical osmotic dilators to evaluate if the medication helps increase the number of dilators.
- Trial name
- NCT03714880
- Testing
- Mifepristone 200 MG
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
The primary goal of this phase I open label study is to determine the safety and tolerability of pNGVL4aCRTE6E7L2 DNA vaccine, as administered by intramuscular (IM) injection with TriGrid™ electroporation to both HIV- or HIV+…
- Conditions
- Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II, Cervical Intraepithelial Neoplasia, Grade III
- Trial name
- NCT04131413
- Testing
- pNGVL4aCRTE6E7L2
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Spinal Cord Injuries
Association of Quantitative and Functional Imaging With Clinical Outcome After Spinal Cord Injury
The overall study aim is to provide additional magnetic resonance imaging parameters of the cervical spinal cord, brainstem and brain and a better understanding of changes after spinal cord injury (SCI) and to define new magnetic…
- Trial name
- NCT03886610
- Testing
- Healthy controls, Subacute SCI patients, Chronic SCI patients
- Where
- Switzerland
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Thyroid Cancer
Outcome of RAI131 Therapy in Patients With Differentiated Thyroid Cancer (Low and Intermediate Risk)
Thyroid cancer is a universally relatively rare neoplasm, accounting for nearly 1-5% of all female cancers and less than 2% of male cancers.
- Trial name
- NCT07056218
- Testing
- neck ultrasound, thyroglobulin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cervical Dysplasia
The Mother-Daughter Project: Merck-4
This project serves to continue a community-based initiative, known as the Kenya Mother-Daughter Cervical Cancer Eradication Project, or the Mother-Daughter Project (MDP), in the Webuye region of Western Kenya.
- Trial name
- Merck-4 (NCT07240220)
- Testing
- Gardisil-9, High Risk HPV DNA Testing, Visual Inspection with acetic acid (VIA) and possible cervical biopsy
- Where
- Kenya
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Non-carious Cervical Lesions
Effect of Wet and Overwet Dentin on the Clinical Performance of Two Universal Adhesive Systems
The aim of this study will be to evaluate the effect of wet and overwet dentin on the long-term clinical performance of two universal adhesive systems used as etch-and-rinse application mode in non-carious cervical lesions…
- Trial name
- NCT07034235
- Testing
- Dentin Wet, Dentin Overwet, Ambar Universal APS Plus; FGM
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Barrett Esophagus, Esophageal Cancer
Study to Evaluate EnteroTracker® as a Sampling Method to Screen for Barrett's Esophagus/Esophageal Cancer
The purpose of this study is to determine whether the EnteroTracker can obtain biomarkers that have been studied to be significant in screening BE and EAC.
- Trial name
- NCT05706025
- Testing
- EnteroTracker
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cervical Pain, Pelvic Pain
The Effect of Nitroprusside on Intrauterine Device (IUD) Insertion
Increasing accessibility of long-acting reversible contraceptive methods, like intrauterine devices (IUDs), is an important strategy to reduce the risk of unintended pregnancy.
- Trial name
- NCT01248091
- Testing
- Nitroprusside Gel
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
HPV Integration
The Predictive Role of HPV Integration in HSIL and Cervical Cancer
The stratified analysis by the level of HPV DNA integration in HSIL and cervical cancer will be drawn to explore whether the status of HPV integration makes any difference in the progression of cervical cancer.
- Trial name
- NCT05300243
- Testing
- HPV integration test
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Retention
Restoration of Non-carious Cervical Lesions With Different Resin Composites and Universal Adhesive
patients with non carious cervical lesions suffer from dentin sensitivity and presence of cavitations and gingival recession. Restoring these lesions with different composites and evaluation of restorations every 6 months will be…
- Trial name
- NCT06393699
- Testing
- composite restoration
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cervix; Pregnancy, Inherited Genetic Conditions (Diagnosis)
Optimization of Cervical Collections in Pregnancy
Fetal cells are not easily obtained from pregnant patients; this curtails testing to assess the health of the fetus and the mother.
- Conditions
- Cervix; Pregnancy, Inherited Genetic Conditions (Diagnosis), Preeclampsia, Fetal Growth Retardation
- Trial name
- OCCP (NCT06323187)
- Testing
- Cervical Sampling
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Dr. Sascha Drewlo
Hypopharyngeal Cancer, Laryngeal Cancer
A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions
This study aims to develop and validate a clinical prediction model for the risk of head and neck cancerous lesions using deep learning combined with AI algorithms, based on multi-center clinical data.
- Conditions
- Hypopharyngeal Cancer, Laryngeal Cancer, Head and Neck Cancer
- Trial name
- ML-HNC-Risk (NCT07532538)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Stage II-IVB Operable HNSCC Oral Cavity, Hypopharynx
Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.
This is a phase II randomized, open label study of durvalumab with/ without tremelimumab as neoadjuvant therapy and durvalumab maintenance after SoC RTx with/without cisplatin as post-surgical adjuvant therapy in treatment naïve…
- Conditions
- Stage II-IVB Operable HNSCC Oral Cavity, Hypopharynx, Oropharynx, Larynx
- Trial name
- NCT03737968
- Testing
- Durvalumab, durvalumab + tremelimumab
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Temporomandibular Disorders
Temporomandibular Disorders With and Without Chronic Neck Pain
Temporomandibular disorders (TMD) are common musculoskeletal conditions frequently accompanied by cervical dysfunction. Although previous studies have demonstrated associations between cervical impairments and temporomandibular…
- Trial name
- NCT07750743
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Healthy Subject
Project Self in Improving Cervical Cancer Screening Rates in Hispanic and African American Women
This trial studies if Project Self can improve the rate of cervical cancer screening in Hispanic and African American women living in Houston, Texas.
- Trial name
- NCT04614155
- Testing
- Educational Intervention, HPV Self-Collection, Questionnaire Administration
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cervical Myofascial Pain Syndrome, Chronic Neck Pain
Type D Personality, and Stigma in Myofascial Pain Syndrome
Cervical myofascial pain syndrome is a chronic musculoskeletal condition characterized by the presence of sensitive trigger points and taut muscle bands, resulting in localized or referred pain, muscle stiffness, and limited…
- Conditions
- Cervical Myofascial Pain Syndrome, Chronic Neck Pain, Type D Personality, Psychological Distress
- Trial name
- NCT07292155
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Volatile Organic Compounds, Microbiome
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- Volatile Organic Compounds, Microbiome, Microbioata, Breath Analysis
- Trial name
- NCT05412758
- Testing
- Oral Stimulant Drink
- Where
- United Kingdom
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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