Clinical trials: Necrotizing Fasciitis
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment
The purpose of this study is to investigate the effects of hyperic oxygen treatment on the immune response in patients with necrotizing soft tissue infections
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- BIONEC-II (NCT02501382)
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Ole Hyldegaard
Soft Tissue Infections, Necrotizing Fasciitis
Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs).
This proposal focuses on highly lethal destructive tissue infections, i.e. necrotizing fasciitis and other necrotizing soft tissue infections (NSTIs), which are associated with high morbidity and mortality.
- Conditions
- Soft Tissue Infections, Necrotizing Fasciitis, Necrotizing Soft Tissue Infections
- Trial name
- INFECT (NCT01790698)
- Where
- 5 sites in Denmark, Norway and 1 more
- Volunteers
- 409 people
- Sponsor
- Karolinska Institutet
Necrotizing Fasciitis, Fournier Gangrene
SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study
Necrotizing soft-tissue infections (NSTI) are rare and life-threatening bacterial infections characterized by subcutaneous tissue, fascia or muscle necrosis.
- Conditions
- Necrotizing Fasciitis, Fournier Gangrene, Necrotizing Soft Tissue Infection
- Trial name
- SKIN-ICU (NCT05116956)
- Testing
- non interventional
- Where
- France
- Volunteers
- 1,033 people
- Sponsor
- Henri Mondor University Hospital
Full-thickness Skin Defects, Degloving Injuries
RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
A prospective randomized within-subject controlled study to compare the clinical performance of conventional autografting with and without the RECELL system on acute non-burn full-thickness skin defects.
- Conditions
- Full-thickness Skin Defects, Degloving Injuries, Crush Injuries, Laceration of Skin
- Trial name
- NCT04091672
- Testing
- Control Intervention (Conventional Autograft), Investigational Intervention (RECELL + more widely meshed autograft)
- Where
- 18 sites in United States
- Volunteers
- 65 people
- Sponsor
- Avita Medical
Burns, Full Thickness Burn
A Single-stage Bilayered Skin Reconstruction With Glyaderm®
The study will explore the potential of utilizing Glyaderm® in a single-stage engrafting process, aiming for a more cost-effective approach.
- Conditions
- Burns, Full Thickness Burn, Necrotizing Fascitis
- Trial name
- NCT06249971
- Testing
- Dermal subsitute Glyaderm + skin graft, Skin graft alone
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- University Hospital, Ghent
Necrotizing Fascitis
Hyperbaric Oxygen Treatment for Necrotizing Fasciitis and Necrotizing Soft Tissue Infections
The goal of this clinical trial is to learn if hyperbaric oxygen is beneficial in treating necrotizing infections and decreasing rates of morbidity and mortality. This study therefore has two aims: 1.
- Trial name
- NCT07170020
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Corewell Health West
Necrotizing Fascitis
Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling
Necrotizing soft-tissue infections (NSTIs, a.k.a. "necrotizing fasciitis" or "flesh-eating bacteria") are aggressive infections that can progress rapidly from mild symptoms to sepsis, multi-organ failure, and death.
- Trial name
- NCT06877793
- Testing
- Administration of indocyanine green (ICG) and fluorescence imaging
- Where
- 8 sites in United States
- Volunteers
- 420 people
- Sponsor
- Eric R. Henderson
Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections
Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections
Daptomycin is a new antimicrobial agent which has activity against resistant Gram positive cocci including MRSA. The phase 3 clinical trials for skin and soft tissue infections (SSTI) with Staphylococci and Streptococci have…
- Conditions
- Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections, Fournier's Gangrene
- Trial name
- NCT00261807
- Testing
- Daptomycin 6mg/kg/day
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Maryland, Baltimore
Necrotizing Fasciitis
Hyperglycemia in Surgical Infections
The primary purpose of this study is to evaluate two glycemic control regimens on clinical outcome in patients with necrotizing soft tissue infections.
- Trial name
- NCT00353275
- Testing
- Strict Glycemic control, Conventional Glycemic Control
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cervical Necrotizing Fasciitis
Factors Associated With Complications of Cervical Necrotizing Fasciitis
Cervical necrotizing fasciitis (CNF) is a rare but severe complication of pharyngeal or dental infections. The infection can rapidly descend into the mediastinum and lead to a life-threatening prognosis.
- Trial name
- NCT02847234
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Hospices Civils de Lyon
Necrotizing Fascitis, Wound Infection
Compare Effects of Dressing With Honey and EUSOL
Honey is super saturated solution containing sugar derived from nectar gathered by honeybee. Honey is viscus supersaturated solution mainly composed of sugar and water along with minor constituents such as minerals, vitamins…
- Trial name
- NCT04831112
- Testing
- Honey, EUSOL
- Where
- Pakistan
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Necrotising Soft Tissue Infections
VACuum-Assisted Closure for Necrotizing Soft Tissue infecTIONs
Intro: Necrotizing and soft tissue infections (NSTI) are life-threatening bacterial infections characterized by subcutaneous tissue, fascia or muscle necrosis. The hospital mortality of NSTI is high, comprised between 20 and 30%.
- Trial name
- VACATION (NCT05071443)
- Testing
- Negative pressure wound therapy (NPWT), Conventional dressing
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Necrotizing Fascitis
VAC and Conventional Dressing in the Healing Process of Necrotizing Fasciitis
Find out the best management of Necrotizing Fasciitis after surgical debridement
- Trial name
- NCT05883033
- Testing
- VAC
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Biomarkers in Patients With Flesh-eating Bacterial Infections
The purpose of this study is to investigate the immune response in patients with necrotizing soft tissue infections (NSTI). The investigation will focus on inflammatory and vasoactive biomarkers as prognostic markers of severity…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- BIONEC (NCT02180906)
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Ole Hyldegaard
Necrotizing Fascitis, Necrotizing Soft Tissue Infection
The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix®
This is a prospective, pilot, parallel group, randomized controlled trial with 1:1 allocation. This will be a single center study coordinated at the Cleveland Clinic Foundation (CCF) Main Campus in Cleveland, Ohio.
- Trial name
- NCT06857708
- Testing
- Cytal® Wound Matrix, MicroMatrix®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Benjamin T. Miller
Necrotizing Fascitis, Fournier Gangrene
FATAL-NSTI Study (Factors Associated With In-hospital mortALity in NSTI).
Necrotizing soft tissue infections (NSTIs) are rare but potentially life-threatening infections involving the skin and underlying tissues such as fat, fascia, and sometimes muscle.
- Conditions
- Necrotizing Fascitis, Fournier Gangrene, Fournier's Gangrene, Soft Tissue Infections
- Trial name
- FATAL-NSTI (NCT07359651)
- Testing
- No Intervention: Observational Cohort
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Cagliari
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial
The purpose of this study is to estimate the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo (saline) on the patient-reported outcome measure Physical Component Summary Score (PCS) of the SF-36 in…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- INSTINCT (NCT02111161)
- Testing
- IVIG (Privigen), Saline 0.9%
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Anders Perner
Necrotizing Fascitis, Cellulitis
Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions
The central venous-arterial carbon dioxide tension difference is used daily in intensive care to establish peripheral tissue hypoperfusion, mainly mediated by a low cardiac index.
- Conditions
- Necrotizing Fascitis, Cellulitis, Septic Shock
- Trial name
- SEPTICO2HBO (NCT07492030)
- Testing
- Echography
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Necrotizing Fasciitis
AFS Compared to AHC in Treatment of Necrotizing Fasciitis NF
Necrotizing Fasciitis (NF) is a potentially life-threatening soft tissue infection. This study is comparing acellular fish skin graft (AFS) to standard of care allograft (AHC) in the treatment of NF.
- Trial name
- NF (NCT06073301)
- Testing
- Acellular Fish Skin Graft (AFS) with Standard of Care Negative Pressure Wound Therapy (NPWT), Acellular Human Cadaver (AHC) with Standard of care Negative Pressure Wound Therapy (NPWT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kerecis Ltd.
Necrotizing Fasciitis
Severe Soft Tissue Infections: Perspectives of Patients and Significant Others
Severe necrotizing soft tissue infection (NSTI), including necrotizing fasciitis, is a life threatening infection that spreads quickly to cutis, sub-cutis, fasciae and muscles.
- Trial name
- NCT02169128
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 30 people
- Sponsor
- Göteborg University