Clinical trials: Neglected Diseases
Scabies; Itch, Scabies
Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study)
This is an open label prospective pharmacokinetic single arm study in Laos PDR. This study will be embedded within a cluster-randomized controlled trial of interventions to address childhood undernutrition (SUANHOAM Trial…
- Trial name
- ITCHY (NCT05500326)
- Testing
- Ivermectin Tablets
- Where
- 5 sites in Laos
- Volunteers
- 120 people
- Sponsor
- Murdoch Childrens Research Institute
Stroke
Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke
This research project is a study designed to address both motor and cognitive changes after stroke. Treatment for SN is elusive however there is support for prism adaptation treatment (PAT).
- Trial name
- NCT02419222
- Testing
- Prism Adaptation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Hemispatial Neglect, Stroke
Vestibular Stimulation to Treat Hemispatial Neglect
The purpose of the current proposal is to pilot a new and potentially improved treatment for neglect. The procedure involves the delivery of transcutaneous small-amplitude current to the vestibular nerves that lie directly below…
- Trial name
- NCT00271388
- Testing
- Transcutaneous current to the vestibular nerve
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Child Abuse, Child Neglect
Child-Parent Psychotherapy - a Feasibility Study for Children in Foster Care
Children in foster care have an increased risk of exposure to adverse experiences during childhood and across the lifespan. In current studies of interventions children in foster care are often excluded, or they are too few to be…
- Conditions
- Child Abuse, Child Neglect, Post-Traumatic Stress Disorder in Children, Parent-Child Relations
- Trial name
- NCT04519229
- Testing
- Child-Parent Psychotherapy
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Kronoberg County Council
Anosognosia, Neglect, Hemispatial
Lesion Site and Neglect Anosognosia in Patients With Left Hemispatial Neglect
The goal of this retrospective is to investigate the relationship between lesion site and neglect anosognosia in subacute or chronic right hemispheric stroke patients with left hemispatial neglect.
- Conditions
- Anosognosia, Neglect, Hemispatial, Stroke, Neurobehavioral Problems
- Trial name
- NCT05654350
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Gazi University
Stroke, Neglect
Comparison of Concentric or Eccentric Virtual Reality Training Program in Subacute-stroke Patients With Hemispatial Neglect
The purpose of this study is to compare and analyze how the visual gaze training in the afferent direction and the visual gaze training in the efferent direction using virtual reality affects the improvement of the neglect…
- Trial name
- NCT04651335
- Testing
- afferent virtual reality program, efferent virtual reality program
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Cognition Disorders, Cognitive Deficits
Smart Autonomous Neuro-Rehabilitation System
Cognitive rehabilitation is defined as a systematic functionally oriented intervention of therapeutic cognitive activities based on the assessment and understanding of patient's brain behavior deficits.
- Trial name
- SANaR (NCT02816008)
- Testing
- Cognitive rehabilitation training with RGS in the clinic, Passive/conventional cognitive training at home.
- Volunteers
- 59 people
- Sponsor
- Universitat Pompeu Fabra
Clubfoot
Percutaneous Achilles Tendon Tenotomy vs Tendo-Achilles Lengthening (TAL) in Neglected Clubfoot Children.
Achilles tendon tenotomy is the established worldwide gold standard for correcting idiopathic clubfoot. However, in neglected cases, surgical interventions such as percutaneous Achilles tendon tenotomy (PAT) and open…
- Trial name
- NCT07561697
- Testing
- Tenotomy of Achilles Tendon, Tendo-Achilles Lengthening
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Muhammad Aamir Latif
Brain Tumours
Investigating Visual Verticality Disorder and Lateropulsion in a Neurosurgical Cohort of Patients With Brain Tumours
The overall objective of this research is to investigate the clinical characteristics pre- and post-brain tumour resection with a focus on visual verticality disorder, and lateropulsion, including neuroimaging analysis, of a…
- Trial name
- NCT06951659
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- The University of Western Australia
Healthy
Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets
The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics of oxantel pamoate tablet after administration of a single and multiple dose in healthy male and female adult volunteers.
- Trial name
- HELP-OXA (NCT06606860)
- Testing
- Oxantel Pamoate
- Where
- Tanzania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Toxoplasmosis, Rhd
Measuring the Prevalence of Toxoplasmosis and Its Socio-economic Consequences
The investigators propose a fast and inexpensive procedure to determine the prevalence of the Toxoplasmosis infection (Toxoplasma Gondii) in the general population, using response times in a cognitive task instead of costly…
- Trial name
- EconToxo (NCT05860998)
- Testing
- Presence of Toxoplasma gondii IgG Antibodies
- Volunteers
- 120 people
- Sponsor
- University of Zurich
The Effects of Mirror Therapy on Patients With Unilateral Neglect After Stroke
Effect of Mirror Therapy on Unilateral Neglect for Patients After Stroke
This is a single-blinded randomized controlled trial to investigate the effects of mirror therapy (MT), with reference to sham mirror (a glass wall) and control (a covered mirror), in reducing unilateral neglect for patients with…
- Trial name
- NCT03854487
- Testing
- Mirror therapy, Covered mirror
- Volunteers
- 21 people
- Sponsor
- The Hong Kong Polytechnic University
Overweight, Obesity
Relationship of Adverse Childhood Experiences to Overweight and Obesity
The purpose of this study is to determine if there is an association between a variety of adverse childhood experiences and overweight and obesity.
- Trial name
- NCT00632346
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Substance Abuse, Child Abuse
Relational Parenting Group for Opioid-addicted Mothers
This study is a randomized trial of interventions to improve parent-child relationships of drug-dependent mothers.
- Trial name
- NCT00319241
- Testing
- Parenting Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Soil-transmitted Helminthiasis, Schistosomiasis
Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders
NIDIAG is an international collaboration on integrated diagnosis-treatment platforms, funded by the European Commission (EC). NIDIAG aims to develop an improved, patient-centred system for delivering primary health care in…
- Conditions
- Soil-transmitted Helminthiasis, Schistosomiasis, Strongyloidiasis, Shigellosis
- Trial name
- NIDIAGDigest (NCT02105714)
- Testing
- Stool culturing for pathogenic bacteria, Kato-Katz technique, Baermann technique
- Where
- 7 sites in Côte d’Ivoire, Indonesia and 2 more
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Stroke
Repetitive Transcranial Magnetic Stimulation in Spatial Attention After Stroke
Randomized Controlled Trial (RCT) aiming at assessing the efficacy of a novel rehabilitation protocol, based on repetitive transcranial magnetic stimulation (r- TMS) in combination with a conventional cognitive treatment (CCT).
- Trial name
- r-TMS (NCT04080999)
- Testing
- r-TMS
- Where
- 2 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Azienda Usl di Bologna
Spatial Neglect, Aphasia
An Assessment of the Prevalence of Spatial Neglect in Stroke Survivors With Aphasia
The purpose of this study is to determine if stroke survivors with aphasia have spatial neglect (Phase 1). If they are determined to have the condition Phase 2 will be offered: which is prism adaptation treatment.
- Conditions
- Spatial Neglect, Aphasia, Stroke
- Trial name
- NCT02068664
- Testing
- prism adaptation treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Stroke, Spatial Neglect
Can we Use c-SIGHT for Spatial Neglect in Stroke Survivors' Homes?
Spatial neglect is a common post-stroke condition in which people may not be aware of anything on one side of the world (usually the same side they lost their movement).
- Conditions
- Stroke, Spatial Neglect, Inattention
- Trial name
- c-SIGHT (NCT04752982)
- Testing
- c-SIGHT intervention, c-SIGHT attentional control
- Where
- 4 sites in United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of East Anglia
Lassa Fever
ARN-75039 Lassa Fever Treatment in West Africa
This multicenter, randomized, open-label Phase 2 clinical trial evaluates the safety, tolerability, and virologic efficacy of ARN-75039, a novel oral antiviral, for treating Lassa fever in hospitalized adults in West Africa.
- Trial name
- NCT07419373
- Testing
- ARN-75039 high, Intravenous ribavirin, ARN-75039 low
- Where
- 4 sites in United States, Nigeria
- Volunteers
- 135 people
- Sponsor
- Arisan Therapeutics, Inc.
Schistosomiasis in Children, Social Acceptance
Adoption of L-PZQ for Schistosomiasis by Endemic Counties - Social Science Research Study
Knowledge, acceptability and perception of paediatric schistosomiasis and its treatment will be explored through a social science-driven mixed-methods approach within three endemic countries: Kenya, Uganda and Côte d'Ivoire.
- Trial name
- ADOPT (NCT05350462)
- Testing
- Community pilot L-PZQ distribution - intervention is NOT part of this observational study
- Where
- 3 sites in Côte d’Ivoire, Kenya and 1 more
- Volunteers
- 225 people
- Sponsor
- Technical University of Munich