Clinical trials: Neoadjuvant Chemotherapy
Neoadjuvant Chemotherapy, Resectable Pancreatic Cancer
Irinotecan Liposome for Resectable Pancreatic Cancer With or Without Addebelizumab
To evaluate the efficacy and safety of irinotecan liposomes with oxaliplatin, 5-fluorouracil (5-FU) / leucovorin (LV) with or without adelizumab for resectable pancreatic cancer by assessing the 12-month EFS rate
- Trial name
- CAPT-02 (NCT06172036)
- Testing
- irinotecan liposome + oxaliplatin + 5-FU / LV, Adebellizumab
- Volunteers
- 180 people
- Sponsor
- Zhejiang University
Neoadjuvant Chemotherapy
Muscle Parameters and Pathological Response in Breast Cancer Patients
The investigators aimed to accurately measure muscle mass and predict pCR to NAC and its effect on clinical outcomes.
- Trial name
- NCT06151379
- Testing
- Neoadjuvant therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Acıbadem Atunizade Hospital
Micrometastases, Neoadjuvant Chemotherapy
Micrometastases in Axillary Lymph Nodes in Breast Cancer, Post-neoadjuvant Chemotherapy
This study aims to investigate the significance of minimal residual axillary disease following NAC, with a particular focus on micrometastases (ypNmi), in comparison to pathologic lymph node-negative (ypN0) or macrometastases…
- Trial name
- NCT06149884
- Testing
- Sentinel lymph node biopsy, axillary lymph node dissection
- Volunteers
- 978 people
- Sponsor
- Gangnam Severance Hospital
Fasting Mimicking Diet, HER2-negative Breast Cancer
Fasting Mimicking Diet Program to ImpRovE ChemoTherapy in Hormone Receptor Postive (HR+), HER2- Breast Cancer
In preclinical research, short-term fasting (STF) protects tumor-bearing mice against the toxic effects of chemotherapy, improves the CD8+ effector T-cell intratumor infiltration, while enhancing the chemotherapy efficacy.
- Conditions
- Fasting Mimicking Diet, HER2-negative Breast Cancer, Hormone Receptor-positive Breast Cancer, Pathological Complete Response
- Trial name
- DIRECT-2 (NCT05503108)
- Testing
- Fasting Mimicking diet program
- Where
- 7 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Ovarian Cancer, Neoadjuvant Chemotherapy
New Prognostic Index for Neoadjuvant Chemotherapy Outcome in Patients With Advanced High-grade Serous Ovarian Cancer
A validated prognostic index for the outcome of advanced high-grade serous ovarian cancer (HGSOC) patients undergoing neoadjuvant chemotherapy (NACT) is still lacking.
- Conditions
- Ovarian Cancer, Neoadjuvant Chemotherapy, Prognostic Cancer Model
- Trial name
- NCT06120309
- Testing
- CRS scoring, Routine blood laboratory testing before treatment
- Where
- China
- Volunteers
- 465 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Neoadjuvant Chemotherapy
ACHP-THP vs EC-THP as Neoadjuvant Therapy for HER2-positive EBC
Breast cancer is the most common malignant tumor in women. EC-TH is one of the standard chemotherapy regimens for HER-2 positive early breast cancer(EBC). Earlier use of trastuzumab may improve DFS rate.
- Trial name
- NCT04172259
- Testing
- Doxorubicin liposome, Cyclophosphamide, Trastuzumab
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Sun Yat-sen University
Triple Negative Breast Cancer, Neoadjuvant Chemotherapy
Impact of Immuno-Oncologic Agent on Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
It analyzes the Tumor microenvironment(TME) changes in non pathologic complete response(pCR) subjects among subjects who were administered neoadjuvant pembrolizumab and those who were not administered neoadjuvant pembrolizumab…
- Conditions
- Triple Negative Breast Cancer, Neoadjuvant Chemotherapy, Pembrolizumab, Tumor Microenvironment
- Trial name
- NCT05910710
- Testing
- Visium, Whole Genome Sequencing(WGS)/Whole Transcriptome Sequencing(WTS)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Gastric Cancer, Neoadjuvant Chemotherapy
Effect of Probiotic Supplements on Gastric Cancer Patients Receiving Neoadjuvant Chemotherapy
Background: Surgery can significantly improve the prognosis of patients with gastric cancer. However, some patients are at a later stage at diagnosis and need to receive neoadjuvant chemotherapy (NACT).
- Trial name
- NCT05901779
- Testing
- live combined Bifidobacteriun, Lactobacillus and Enterococcus capsules
- Where
- China
- Volunteers
- 318 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Monitoring the Response of Breast Cancer to Neoadjuvant Chemotherapy Using SE and SWE
Comparative Study Between Shear and Strain Elastography in Monitoring the Response to NAC in Breast Cancer Patients
The aim is to evaluate tumor stiffness changes through a comparative study between shear and strain elastography in monitoring the response of breast cancer to neoadjuvant chemotherapy
- Trial name
- NCT05852743
- Testing
- shear wave and strain elastography
- Volunteers
- 65 people
- Sponsor
- Assiut University
Colorectal Cancer, Neoadjuvant Chemotherapy
Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement for Left-Sided Obstructive Colonic Cancer
Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergency surgery, with morbidity…
- Conditions
- Colorectal Cancer, Neoadjuvant Chemotherapy, Stent, Obstruction
- Trial name
- NACSOC-02 (NCT05202314)
- Testing
- Immunotherapy (Camrelizumab)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
Efficacy and Safety of Immunotherapy Combined With Neoadjuvant Chemotherapy in Patients With Locally Advanced HPV (-) HNSCC
Efficacy and Safety of Immunotherapy Combined With Neoadjuvant Chemotherapy in Patients With Locally Advanced HPV (-) Head and Neck Squamous Cell Carcinoma: a Phase II Clinical Trial
There are few clinical trials of chemotherapy combined with immunotherapy in the neoadjuvant stage of locally advanced head and neck squamous cell carcinoma.
- Trial name
- NCT04929067
- Testing
- immunotherapy combined with neoadjuvant chemotherapy in patients with locally advanced HPV (-) head and neck squamous cell carcinoma
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastric Cancer, CT Images
DLCS for Predicting Neoadjuvant Chemotherapy Response
The early noninvasive screening of patients suitable for neoadjuvant chemotherapy (NCT) is essential for personalized treatment in locally advanced gastric cancer (LAGC).
- Conditions
- Gastric Cancer, CT Images, Deep Learning, Neoadjuvant Chemotherapy
- Trial name
- NCT05617469
- Testing
- develop and visualized a radio-clinical signatures from pretreatment oversampled CT images
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Zhejiang Cancer Hospital
Cervical Cancer, Neoadjuvant Chemotherapy
Neoadjuvant Chemotherapy Followed by Chemoradiation Versus Chemoradiation for Stage IIIC Cervical Cancer Patients: A Randomized Phase III Trial
Evaluate the efficacy and safety of neoadjuvant chemotherapy (NAC) with albumin-bound paclitaxel and carboplatin followed by chemoradiation therapy (CRT) for stage IIIC cervical cancer patients with carcinoma >4 cm in greatest…
- Conditions
- Cervical Cancer, Neoadjuvant Chemotherapy, Bulky Neoplasm
- Trial name
- N6C (NCT05367206)
- Testing
- Albumin-Bound Paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sun Yat-sen University
Hyperthermic Intraperitoneal Chemotherapy, Neoadjuvant Chemotherapy
Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial)
Background: Neoadjuvant chemotherapy (NACT) is an important treatment option for patients with ovarian cancer. Although intravenous NACT can improve optimal resection rates and decrease surgical morbidity and mortality, these…
- Trial name
- NHIPEC (NCT05246020)
- Testing
- HIPEC, intravenous chemotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Neoplasm, Breast, Neoadjuvant Chemotherapy
To Accurately Assess Lymph Node Response to NACT by Wire Localization of Clip-marked Lymph Nodes
The investigator developed this protocol to accurately assess lymph node response to neoadjuvant chemotherapy in clinical stage N1 (cN1) breast cancer patients.
- Conditions
- Neoplasm, Breast, Neoadjuvant Chemotherapy, Lymph Node Metastases, Response
- Trial name
- NCT03715686
- Testing
- wire localization
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Peking University
High-risk Locally Advanced Colorectal Cancer, Neoadjuvant Chemotherapy
FOLFOXIRI for Neoadjuvant Treatment of High-risk Locally Advanced Colorectal Cancer
The main cause of recurrence after surgical treatment of colorectal cancer is distant metastasis. Neoadjuvant chemotherapy has potential benefits of improving the effectiveness of chemotherapy.
- Conditions
- High-risk Locally Advanced Colorectal Cancer, Neoadjuvant Chemotherapy, FOLFOXIRI Regimen
- Trial name
- NCT05018182
- Testing
- Oxaliplatin, Irinotecan, Folinic Acid
- Where
- China
- Volunteers
- 69 people
- Sponsor
- West China Hospital
HER2-negative Breast Cancer, Neoadjuvant Chemotherapy
Efficacy and Safety of Dose-dense Chemotherapy (ddEC-ddP) for Neoadjuvant Chemotherapy of HER2-negative Breast Cancer
Recent clinical studies showed that breast cancer patients especially for those with lymph node metastasis may benefit from dose-dense chemotherapy, like adriamycin and cyclophosphamide (AC) q2w×4→ paclitaxel (P) q2w×4.
- Trial name
- NCT04576143
- Testing
- Epirubicin, Cyclophosphamid, Docetaxel
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epithelial Carcinoma, Ovarian, Neoadjuvant Chemotherapy
Paclitaxel i.v. Plus Cisplatin i.p for NACT in Patients With Advanced Ovarian Cancer
To test the effect of intravenous paclitaxel plus intraperitoneal cisplatin for neo-adjuvant chemotherapy in patients with advanced ovarian cancer, the investigators conducted a phase III single arm clinical trial.
- Trial name
- NCT04885270
- Testing
- cisplatin i.p.
- Where
- China
- Volunteers
- 50 people
- Sponsor
- West China Second University Hospital
Gastric Cancer, Neoadjuvant Chemotherapy
Dragon III-Phase 3: Neoadjuvant Chemotherapy (FLOT Versus SOX) for Gastric Cancer
DRAGON III research, Neoadjuvant Chemotherapy (FLOT versus SOX) for Gastric Cancer, is an investigator initiated; phase 3, open label, multi-center randomized controlled study.
- Trial name
- NCT04384601
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Ruijin Hospital
Gastric Cancer, Magnetic Resonance Imaging
CT and MRI in Prediction of Response in Patients With Gastric Cancer Following Neoadjuvant Chemotherapy and/or Immunotherapy
This is a prospective and observational clinical study for seeking out a better way to predict the pathologic complete response (pCR) in patients with advanced gastric cancer (AGC) based on the post-neoadjuvant treatment Magnetic…
- Conditions
- Gastric Cancer, Magnetic Resonance Imaging, Tomography, X-Ray Computed, Neoadjuvant Immunotherapy
- Trial name
- NCT04913896
- Testing
- PD-1 inhibitor
- Volunteers
- 200 people
- Sponsor
- The First Hospital of Jilin University