Clinical trials: Neonatal Respiratory Failure
Respiratory Insufficiency
Humidified High Flow Nasal Cannula Versus Nasal Intermittent Positive Ventilation in Neonates
The investigators hypothesize that the Humidified High Flow Nasal Cannula(HHFNC) is effective and safe as primary respiratory support in neonate with respiratory distress syndrome(RDS).
- Trial name
- NCT02499744
- Testing
- NIPPV, HHFNC
- Volunteers
- 200 people
- Sponsor
- Gao WeiWei
PPHN, Hypoxic Respiratory Failure
Predictors of Inhaled Nitric Oxide Responsiveness in Patients With PPHN
To identify biochemical, clinical, or genetic biomarkers that may predict responsiveness to iNO in neonates with PPHN/HRF. The primary outcome will be identification of any biomarker(s) associated with response to iNO therapy.
- Trial name
- PINOR (NCT06043635)
- Sponsor
- Nationwide Children's Hospital
Pulmonary Hypertension, Familial Persistent, of the Newborn
A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
This study will evaluate whether IV sildenafil can reduce the time on inhaled nitric oxide treatment and reduce the failure rate of available treatments for persistent pulmonary hypertension of the newborn.
- Trial name
- NCT01720524
- Testing
- iv sildenafil
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 59 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Melanoma, Li-Fraumeni Syndrome
Clinical Genetics Branch Eligibility Screening Survey
Background: Clinical Genetics Branch (CGB) researchers study individuals and populations at high genetic risk of cancer in order to improve our understanding of cancer and to improve cancer care.
- Conditions
- Melanoma, Li-Fraumeni Syndrome, Pulmonary Blastoma, Chordoma
- Trial name
- NCT07005297
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Congenital Heart Disease, Advanced Heart Failure
TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease
TORCH-LATAM-003 is a pragmatic stepped-wedge cluster randomized trial evaluating a regional pathway for children and adults with congenital heart disease and advanced cardiac and/or respiratory failure who may require heart…
- Conditions
- Congenital Heart Disease, Advanced Heart Failure, Respiratory Failure, Heart Transplantation
- Trial name
- TORCH-003 (NCT07837024)
- Testing
- TORCH Congenital Advanced Therapies Pathway (TORCH-CATP)
- Volunteers
- 360 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Cystic Fibrosis, Chronic Respiratory Failure
Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure.
There is no randomised controlled trials to determine the clinical effects of long term Non-Invasive Ventilation in Cystic Fibrosis patients.
- Trial name
- NCT00208078
- Testing
- pressure support ventilator
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Cochin Hospital
Respiratory Insufficiency
Pressure-limited Ventilation Versus Volume-targeted Ventilation in Term Newborns
A randomised controlled trial comparing volume-targeted ventilation to pressure-limited ventilation in infants born at or near term.
- Trial name
- NCT02358460
- Testing
- Ventilation delivered by SLE5000 ventilator
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Neonatal Respiratory Failure
Hypothermia During ECMO to Decrease Brain Injury
Newborn infants with severe respiratory failure are treated with extracorporeal membrane oxygenation (ECMO), a modified form of cardiopulmonary bypass.
- Trial name
- NCT01675388
- Testing
- Hypothermia
- Where
- United States
- Sponsor
- Sood, Beena G., MD, MS
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns
This is a prospective, randomized, double-blind, placebo controlled, single center study to compare low dose hydrocortisone vs placebo in systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Trial name
- CORTISoL (NCT02700828)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 32 people
- Sponsor
- Semmelweis University
Acute Respiratory Distress Syndrome
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
A randomized, concurrent controlled trial to assess if adding sigh breaths to usual invasive mechanical ventilation of victims of trauma who are at risk of developing ARDS will decrease the number of days they require invasive…
- Trial name
- SiVent (NCT02582957)
- Testing
- Sigh breaths
- Where
- 15 sites in United States
- Volunteers
- 524 people
- Sponsor
- University of Minnesota
Congenital Disorders
Constrictive Pericarditis in the Adult Congenital Cardiac Population
The primary aim of this study is to determine the clinical and radiographic findings with constrictive pericarditis in the adult congenital population and determine the degree of right heart failure and dilation from pulmonary…
- Trial name
- NCT00268086
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Healthcare of Atlanta
PPHN, Persistent Pulmonary Hypertension of the Newborn
Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN)
Sildenafil is efficacious in newborns with persistent pulmonary hypertension and its use will reduce the need for inhaled nitric oxide.
- Conditions
- PPHN, Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure
- Trial name
- NCT01069861
- Testing
- sildanefil
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Premature Birth, Sedation During Labor and Delivery; Complications, Pulmonary
Magnesium for Neonatal Neuroprotection and Mothers
Magnesium is a treatment for mothers to protect brains of babies born early. This study investigates combined effects of magnesium and spinal or epidural anesthesia on mothers having cesareans.
- Conditions
- Premature Birth, Sedation During Labor and Delivery; Complications, Pulmonary, Respiratory Depression
- Trial name
- MnMs (NCT01482078)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Myotonic Dystrophy 1, Steinert Disease
Ventilatory Response After Non Invasive Ventilation in Type 1 Myotonic Dystrophy
It has been suggested that patients with Myotonic Dystrophy type 1 have primary altered ventilatory response to chemical stimuli and chronic hypoventilation is related not always to muscle weakness.
- Trial name
- NCT02880735
- Testing
- Non Invasive Ventilation.
- Where
- Mexico
- Volunteers
- 27 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Mucoviscidosis, Pulmonary Insufficiency
Measurement of Lung Water by Transpulmonary Thermodilution in Lung Transplanted Patients
Repeated measurements of lung water by single transpulmonary thermodilution during the first postoperative days following lung transplantation
- Trial name
- PICCO-LungT (NCT00834054)
- Testing
- Double-lung transplantation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hopital Foch
Respiratory Distress Syndrome, Newborn
The Use of Heliox Via Nasal CPAP to Prevent Early CPAP Failure in Premature Infants: A Feasibility Study
The purpose of this study is to evaluate the safety and utility of using heliox gas in combination with nasal CPAP in premature infants.
- Trial name
- NCT00739115
- Testing
- Heliox gas
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hawaii Pacific Health