Clinical trials: Neonates
Anodontia
Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders
The congenital absence of teeth, commonly referred to as hypodontia or tooth agenesis, is a common developmental anomaly of human dentition that affects approximately 20% of the population.
- Trial name
- NCT00026026
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Missing Teeth
A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials.
The purpose of this investigator-initiated study is to compare new bone formation through histomorphometric analysis following maxillary sinus augmentation using two different bone graft materials.
- Trial name
- NCT03059914
- Testing
- InterOss, Bio-oss
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Preterm Birth, Microbial Colonization
Vaginal, Placental and Neonatal Buccal Mycobiota and Microbiome in Preterm Birth
Microbiota contributes to the immunological, hormonal and metabolic homeostasis of the host. As in all natural orifices in the body, there is also a microbiota and mycobiota specific to the vagina.
- Trial name
- NCT04165252
- Testing
- Collection of vaginal, neonatal buccal and placental samples
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Koç University
Preterm, Infant, Premature, Diseases
The Effect of Lullaby and Breastmilk Smell on Preterm Newborns
The goal of this clinical trial is to investigate the effect of live lullaby from mother voice, and breast milk smell on pyhsiological parameters, comfort and maternal attachment levels of preterm newborns who are between 35-37…
- Conditions
- Preterm, Infant, Premature, Diseases, Postpartum Depression, Mother-Infant Interaction
- Trial name
- NCT05830955
- Testing
- Lullaby group, Breast milk group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Neonatal Respiratory Failure
Development of Modified Combined Apgar Scoring System for Evaluation of Infants in the Delivery Room
Apgar scoring system has been widely used for the evaluation of the infant's postnatal condition. As conventional Apgar scoring system is affected by gestational age and resuscitative efforts, there is a need for development of…
- Trial name
- NCT03166826
- Testing
- Modified Apgar Scoring System
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pain, Hypospadias
Dexmedetomidine Infusion and Surgical Pleth Index In Pediatrics
This non-invasive dimensionless score index -SPI-reflects the Patients' sympathetic response to surgical stimulation. Its effectiveness in detecting the balance between nociceptor activation and analgesia was not only reported…
- Trial name
- NCT05727969
- Testing
- Dexmedetomidine, Lactated Ringer, Hypospadias
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Neonatal Resuscitation, Clinical Competence
POV Video and Mental Practice Training for Neonatal LMA Insertion
This prospective, randomized, single-blind simulation study aims to evaluate and compare the educational efficacy of a hybrid instructional modality-combining point-of-view (POV) video training and structured mental practice…
- Conditions
- Neonatal Resuscitation, Clinical Competence, Simulation Training, Airway Management
- Trial name
- NCT07678424
- Testing
- Standard Instructor Demonstration, POV Video and Mental Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Gaucher Disease
Exploration of Immunity in Gaucher Disease
Gaucher disease (GD), the inherited deficiency of the lysosomal enzyme glucocerebrosidase is characterized with accumulation of abnormal lipid in cells of the immune system, called macrophages.
- Trial name
- NCT01358188
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- O & O Alpan LLC
Alport Syndrome, Hereditary Kidney Disease
Alport Therapy Registry - European Initiative Towards Delaying Renal Failure in Alport Syndrome
The hereditary type IV collagen disease Alport syndrome leads to kidney failure early in life. Currently there are no specific medications approved for treatment, however, several therapies have been evaluated preclinically and…
- Conditions
- Alport Syndrome, Hereditary Kidney Disease, Pediatric Kidney Disease, Thin Basement Membrane Disease
- Trial name
- Alport-XXL (NCT02378805)
- Testing
- ACE-inhibitor, Angiotensin-receptor blocker (ARB), HMG-Coenzyme inhibitor (statin)
- Where
- Germany
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Hospital Goettingen
Shaken Baby Syndrome
Parents Helping Infants Study: Educational Intervention to Change the Knowledge, Attitudes and Behaviour of New Parents About Early Infant Crying
This research project seeks to implement an early intervention program that can be effective in the prevention of shaken baby syndrome (SBS) and infant abuse.
- Trial name
- NCT00175422
- Testing
- The Period of PURPLE Crying Program
- Where
- Canada
- Volunteers
- 1,833 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hemophilia A
Trial of Rituximab Versus Oral Cyclophosphamide to Eradicate or Suppress Autoimmune Anti-Factor VIII Antibodies in Acquired Hemophilia A
The purpose of this study is to evaluate the rate of response when administering rituximab to suppress or eliminate the anti-body in a patient's blood that inhibits the effectiveness of their factor replacement product compared…
- Trial name
- NCT00306670
- Testing
- Rituxan, prednisone
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Friedreich Ataxia
A Single Ascending Dose Study of DT-216P2 in Normal Healthy Participants
This purpose of the study is to evaluate the safety, tolerability and pharmacokinetics of single ascending doses of DT-216P2 administered either subcutaneously (SC) and intravenously (IV) in normal healthy participants.
- Trial name
- NCT06772870
- Testing
- DT-216P2, Saline
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Design Therapeutics, Inc.
Infections, Streptococcal
Immunization of Children Between 8 Weeks and 2 Years of Age With GSK Pneumococcal Vaccine GSK1024850A
The aim of the study is to evaluate the immunogenicity, safety and reactogenicity of GSK Biologicals' pneumococcal conjugate vaccine GSK1024850A.
- Trial name
- NCT01175083
- Testing
- GSK1024850A (Synflorix), Tritanrix-HepB/Hib, Polio Sabin
- Where
- Burkina Faso
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Metabolic Availability of Methionine From Chickpeas in Adult Men
The research study is being done so we can determine the quality of the protein present in Canadian chickpeas. Amino acids are the building blocks of protein and protein quality is determined by the amount of amino acids present…
- Trial name
- NCT03339154
- Testing
- Dietary Intakes
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Dilated Cardiomyopathy
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of AZD0233 following single and multiple ascending dose (SAD and MAD) administration in healthy participants.
- Trial name
- NCT06381466
- Testing
- AZD0233
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mucoviscidosis Involving the Lung
Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test
The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat.
- Trial name
- BUBBLE TEST (NCT03584841)
- Testing
- Iontophoresis sessions in forearm of subjects with pilocarpine
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
CVI - Common Variable Immunodeficiency
Improving the Diagnosis of Common Variable Immune Deficiency
This is an observational, case-control study with a single blood draw among two cohorts, patients with antibody deficiency (e.g., CVID) and healthy controls.
- Trial name
- NCT03335605
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Respiratory Distress Syndrome
Fetal Lung Volume and Pulmonary Artery Resistance Index Measurement in Term Diabetic Pregnancy
The aim of this study is to determine cut-off values for fetal lung volume by VOCAL and pulmonary artery resistance index by pulsed Doppler in fetuses of diabetic mothers, and correlate the results with postnatal respiratory…
- Trial name
- NCT02586922
- Testing
- Three-dimensional (3D) ultrasonography
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Cements, Tooth Abnormalities
Artificial Root-End Barriers
This study retrospectively looks to determine the clinical success of ProRoot MTA used as an artificial apical barrier in teeth with immature apices.
- Trial name
- NCT00595842
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Very Low Birth Weight Infant
Fluid Balance Study in Sick Neonates
The purpose of this study is to determine if routinely recording fluid balance in sick neonates admitted to the pediatric ward is reliable and useful. The investigators' hypothesis is that it is not useful and reliable.
- Trial name
- NCT00962754
- Testing
- physician no insight in the fluid balance chart
- Where
- Netherlands
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Princess Amalia Children's Clinic
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