Clinical trials: Neoplasia Prostate
Solid Malignancies, Metastatic Castrate-resistant Prostate Cancer
Pharmacodynamic Study With FLT-PET/CT in Patients With Prostate/Other Solid Malignancies Treated With High Dose Axitinib
The main purpose of this study is to learn more about the safety of an investigational drug, axitinib. An investigational drug is a drug that has not been approved by the Food and Drug Administration (FDA) and is available for…
- Trial name
- NCT01540526
- Testing
- axitinib
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Prostate Cancer
Neoadjuvant Pembrolizumab Plus Androgen Axis Blockade Prior to Prostatectomy for High Risk Localized Prostate Cancer
Pembrolizumab will be administered at a dose of 200 mg will be administered as a 30 minute IV infusion every 3 weeks. Enzalutamide will be administered at dose of 160 mg orally every day.
- Trial name
- NCT03753243
- Testing
- Pembrolizumab, Enzalutamide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mark Garzotto, MD
Prostate Cancer
Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP
The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.
- Trial name
- NCT03529643
- Testing
- Dexmedetomidine, Without dexmedetomidine
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Prostate Cancer
Randomized Phase II Trial of Doxil With or Without Dexamethasone for Metastatic Hormone Refractory Prostate Cancer
The primary objective of this study is to assess disease response to Doxil in patients with hormone refractory prostate cancer with or without dexamethasone pre-treatment.
- Trial name
- NCT00176293
- Testing
- dexamethasone, doxorubicin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Kentucky
Prostate Cancer
the Beijing Randomized Study Of Prostate Cancer Screening
BROPCS is a randomized trial study comparing the effectiveness of traditional systematic biopsies and bpMRI followed targeted biopsies with PSA > 4ng/ml in initial screening.
- Trial name
- BROPCS (NCT05961514)
- Testing
- Target biopsies, systemic biopsies
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Prostate Cancer
Therapy for Erectile Dysfunction Adaptation of ACT for Compliance With an Erectile Rehabilitation Program
The investigators know that treatment for prostate cancer and erectile dysfunction can impact sexual health and quality of life. They want to learn how the treatment affects one's emotional and social well-being.
- Trial name
- ACT-ED (NCT01275404)
- Testing
- Sexual Medicine Rehabilitation Program + nurse practitioner information phone calls, Sexual Medicine Rehabilitation Program + Acceptance and Commitment Therapy for Erectile Dysfunction
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005847
- Testing
- recombinant interferon alfa, estramustine phosphate sodium, isotretinoin
- Where
- 19 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Prostate Neoplasms
Evaluation of Truebeam for Low-Intermediate Risk Prostate Cancer
The primary safety purpose of this study is to estimate the rates of immediate and long-term high grade (grade 3-5) gastrointestinal and genitourinary side effects during the five years after TrueBeam stereotactic body…
- Trial name
- NCT01581749
- Testing
- "TrueBeam" stereotactic body radiosurgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Albert DeNittis
Prostate Cancer
SABR Including Regional Lymph Node Irradiation for Patients With High Risk Prostate Cancer (SATURN)
Current treatment options for high risk localized prostate cancer include radical prostatectomy +/- postoperative radiotherapy, radical radiotherapy with androgen deprivation therapy.
- Trial name
- SATURN (NCT01953055)
- Testing
- Stereotactic ablative radiotherapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Low-Fat Fish Oil Diet for Prostate Cancer Prevention
Studies on patterns of how many men get prostate cancer in other countries show that environment contributes to the high incidence of prostate cancer in the United States.
- Trial name
- NCT00798876
- Testing
- Fish Oil, Vitamin E supplement, Western Diet
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer
Prospective Clinical Utility Study to Assess the Impact of Decipher on Treatment Decisions After Surgery
The influence of Decipher test on urologist and patient treatment plan choices immediately post RP and at the time of PSA rise or BCR
- Trial name
- PRO-IMPACT (NCT02080689)
- Testing
- Decipher
- Where
- 19 sites in United States
- Volunteers
- 286 people
- Sponsor
- GenomeDx Biosciences Corp
Prostatic Neoplasms
A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer
The purpose of Parts 1, 2A, and 2B of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 and the purpose of Part 2C of this study is to determine how safe the…
- Trial name
- NCT06095089
- Testing
- JNJ-78278343, JNJ-87189401, Apalutamide
- Where
- 22 sites in United States, Australia and 3 more
- Volunteers
- 355 people
- Sponsor
- Janssen Research & Development, LLC
Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Advancing Care Coordination Between Cancer and Primary Care Teams for Complex Cancer Survivors
The purpose of this randomized clinical trial is to learn if 'complex' cancer patients who receive care guided by a health system intervention, Primary Care Connect (PC2) have their risks of cardiovascular disease (CVD) managed…
- Conditions
- Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), Bladder Cancer, Prostate Cancer (Adenocarcinoma)
- Trial name
- ACCESS-PC (NCT06834204)
- Testing
- PC2: Primary Care Connect
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rutgers, The State University of New Jersey
Prostate Cancer
Trial of eRapa in Prostate Cancer Patients
This study is to determine the safety, pharmacokinetics/pharmacodynamics, and immunologic impact of encapsulated rapamycin in patients with low risk prostate cancer under active surveillance.
- Trial name
- NCT03618355
- Testing
- eRapa (encapsulated rapamycin)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rapamycin Holdings, Inc. dba Emtora Biosciences
Prostate Cancer
Hormone Therapy and Docetaxel or Hormone Therapy Alone in Treating Patients With Metastatic Prostate Cancer
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as goserelin, may stop the adrenal glands from making androgens.
- Trial name
- NCT00104715
- Testing
- antiandrogen therapy, docetaxel, goserelin acetate
- Where
- 41 sites in France
- Volunteers
- 385 people
- Sponsor
- UNICANCER
Prostate Cancer
A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
The purpose of this study is to find out in the real-world setting, if darolutamide is safe and effective for patients diagnosed with prostate cancer that has not spread to other parts of the body.
- Trial name
- DAROL (NCT04122976)
- Testing
- Darolutamide(Nubeqa, BAY1841788)
- Where
- 40 sites in United States, Argentina and 15 more
- Volunteers
- 805 people
- Sponsor
- Bayer
Prostate Cancer
18F-PSMA-1007 PET Imaging to Detect Primary Prostate Cancer
To study the added value of 18F-PSMA-1007 PET to mpMRI in the detection of local prostate cancer lesions.
- Trial name
- PICture (NCT04487847)
- Testing
- 18F-PSMA-1007 PET/CT
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer, Prostate Cancer Metastatic
68Ga PSMA-11 PET/CT in Recurrent Prostate Cancer
The goal of this research is to examine the ability of Gallium-68 (68Ga) Prostate-Specific Membrane Antigen-11 (PSMA-11) positron emission tomography/computed tomography (PET/CT) to detect sites of recurrent prostate cancer in…
- Conditions
- Prostate Cancer, Prostate Cancer Metastatic, Prostate Cancer Metastatic to Bone
- Trial name
- NCT04483414
- Testing
- 68Ga PSMA-11 injection, Positron Emission Tomography/Computed Tomography
- Where
- United States
- Sponsor
- Dana Mathews
Prostate Cancer
Stereotactic Body Radiotherapy (SBRT) for Prostate Cancer
The purpose of this study is to evaluate the incidence of urinary and gastrointestinal acute and late side effects in patients treated with stereotactic body radiotherapy (SBRT) to the prostate.
- Trial name
- SMART (NCT00941915)
- Testing
- SBRT Prostate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Prostate Cancer
CASCARA: Castration Sensitive Carboplatin, Cabazitaxel and Abiraterone
This is a phase II clinical trial in patients with metastatic castration sensitive prostate cancer. The objective of the study is to determine the efficacy and further define the safety of the treatment combination.
- Trial name
- NCT03934840
- Testing
- Cabazitaxel, Carboplatin, Abiraterone
- Where
- 8 sites in United States
- Volunteers
- 61 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
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