Clinical trials: Neoplasm, Brain
Brain Metastasis, Non-small Cell Lung Cancer
Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer
The study objective is to evaluate the safety and efficacy of patupilone with respect to early progression and response of patients with non-small cell lung cancer (NSCLC) metastatic to the brain, who have progressed after…
- Trial name
- NCT00219297
- Testing
- Patupilone
- Where
- 12 sites in United States
- Volunteers
- 50 people
- Sponsor
- Novartis Pharmaceuticals
Brain Tumor
A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors
This is a single center, multi-arm, biomarker-driven phase 1 study to assess the RP2D, PK/PD, safety, and activity of tepotinib in participants with MET alterations and brain tumors.
- Trial name
- NCT05120960
- Testing
- tepotinib, tepotinib plus osimertinib
- Sponsor
- M.D. Anderson Cancer Center
Brain and Central Nervous System Tumors
Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation or bone marrow transplantation may allow the doctor to give higher doses…
- Trial name
- NCT00025324
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- 4 sites in United States, Australia and 1 more
- Sponsor
- Children's Hospital Los Angeles
Brain and Central Nervous System Tumors
Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004224
- Testing
- cyclophosphamide, etoposide, vincristine sulfate
- Where
- 7 sites in Argentina, Canada and 5 more
- Volunteers
- 65 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Brain (Nervous System) Cancers, Glioma
Clinical, patHOlogical and Imaging Project of nEuro-oncology (HOPE)
Primary central nervous system (CNS) tumors, the vast majority (>90%) occurring in the brain and the remainder occurring in the meninges, spinal cord, and cranial nerves, showing an annual incidence of about 6-8 people per…
- Conditions
- Brain (Nervous System) Cancers, Glioma, Brain Tumor
- Trial name
- NCT05859659
- Testing
- This study does not intervene in this process.
- Where
- China
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Yaou Liu
Sarcoma, Neuroblastoma
A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors
Background: Pazopanib, a drug that inhibits the growth of new blood vessels in tumors, was recently approved by the Food and Drug Administration to treat advanced kidney cancer in adults.
- Conditions
- Sarcoma, Neuroblastoma, Wilms Tumor, Osteosarcoma
- Trial name
- NCT01130623
- Testing
- Pazopanib (GW786034)
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Carcinoma, Small Cell
Neurocognitive Function After Prophylactic Cranial Irradiation & Hippocampal Sparing in LD SCLC Patients - a Pilot Study
Small cell lung cancer (SCLC) harbors a high risk for brain metastases. Prophylactic whole brain radiotherapy (PCI)) is the standard treatment for these patients after completing chemo-radiotherapy to the chest, with a 5%…
- Trial name
- NCT02366741
- Testing
- Whole brain radiotherapy with reduced dose to the hippocampi
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Sheba Medical Center
Dementia, Mild, Dementia of Alzheimer Type
Autonomic Involvement in Patient With Cognitive Decline
Prospective interventional study with a device for comparing autonomic parameters among patients with different forms of cognitive decline
- Trial name
- NCT06292741
- Testing
- Sudoscan
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Neoplasms
A Study of Local Therapy for the Treatment of Brain Metastases From HER2 Positive Breast Cancer
This study aims to show that brain metastases from Human Epidermal Growth Factor Receptor Type 2 (HER2) positive breast cancers are able to be controlled by local therapies, Stereotactic Radiosurgery (SRS) and/or Neurosurgery…
- Trial name
- Local HER-O (NCT02898727)
- Testing
- Local Therapy
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Non-Small Cell Lung Cancer, Brain Metastases
Safety Study of Radiotherapy and Concurrent Erlotinib (Tarceva®) for Brain Metastases From a Non-Small Cell Lung Cancer
Lung cancer is a leading cause of death worldwide. Brain metastases manifest as the first site of disease failure in between 15-30% of patients with non-small cell lung cancer (NSCLC).
- Trial name
- NCT00536861
- Testing
- erlotinib
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Amsterdam UMC, location VUmc
Newly Diagnosed Glioblastoma Who Underwent at Least Partial Resection of the Tumor Surgically
Potentiation of Chemotherapy in Brain Tumors by Zinc
Glioblastoma (GB) is the most common and aggressive type of primary malignant brain tumor in adults. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor.
- Trial name
- NCT04488783
- Testing
- zinc and ascorbate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Neurologic Disorders
Evaluation and Treatment of Neurosurgical Disorders
Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants.
- Trial name
- NCT00060541
- Testing
- Laboratory tests, Radiological exams
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Relapsed Neuroblastoma
Standardized Protocol of Surgery and Radiation for Patients With Brain Metastases in Relapsed Neuroblastoma
HITC001 is a single institution study to evaluate the efficacy of using a standardized protocol of surgery and radiation for patients with brain metastases in relapsed neuroblastoma.
- Trial name
- NCT03406273
- Testing
- Cerebral Spinal (CS) radiation, Focal radiotherapy (SRS)
- Where
- United States
- Sponsor
- Giselle Sholler
Low Grade Gliomas, Craniopharyngioma
SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors
Brain tumours are the commonest solid tumours in children and the second most common neoplasms overall in this patient population. Radiotherapy plays an important part in the management in a majority of these tumours.
- Conditions
- Low Grade Gliomas, Craniopharyngioma, Ependymomas, Meningiomas
- Trial name
- SCRT (NCT00517959)
- Testing
- Stereotactic Conformal radiotherapy, Conventional radiotherapy
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Hospital
Obese Patients, Hypothalamic Neoplasms
KETO-TUMOR: a Study on Brain Tumors and Central Obesity
Hypothalamic-chiasmatic tumours account for 5-10% of CNS tumours in children and can compromise hypothalamic function, causing alterations in energy balance and weight gain.
- Trial name
- NCT07396896
- Testing
- Dietary intervention
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Meyer Children's Hospital IRCCS
Neoplasm Metastasis, Lung Neoplasms
Proton MR Spectroscopy of Brain Metastases in Evaluation of Treatment Response.
The aim of the study is to investigate the feasibility of in vivo single volume MR spectroscopy in evaluation of treatment response in patients with brain metastases, using 3T MR instrument.
- Conditions
- Neoplasm Metastasis, Lung Neoplasms, Breast Neoplasms, Melanoma
- Trial name
- NCT00184288
- Where
- Norway
- Sponsor
- Norwegian University of Science and Technology
Non Invasive Diagnosis of Glioma
Non Invasive IDentification of Gliomas With IDH1 Mutation
The recurrent mutation IDH1Arg132His leads to the cellular accumulation of D-2-hydroxyglutarate (2-HG), thus representing a diagnostic marker (this change is almost specific for gliomas) and prognostic (mutated gliomas have…
- Trial name
- IDASPE (NCT01703962)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Whole-Brain Radiotherapy
Anlotinib Plus Whole-Brain Radiotherapy for Brain Metastases in SCLC Patients.
This study is a multicenter, randomized, prospective Phase III study to evaluate the efficacy and safety of anlotinib plus whole-brain radiotherapy (WBRT) compared with WBRT alone in small cell lung cancer (SCLC) patients with…
- Trial name
- NCT07443397
- Testing
- Anlotinib, Whole-brain Radiotherapy
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pediatric Brain Tumor, Glioma
Valproic Acid in Childhood Progressive Brain Tumors
The study investigates valproic acid added to radiation and temozolomide therapy (standard of care) for progressive or recurrent pediatric brain tumors.
- Conditions
- Pediatric Brain Tumor, Glioma, Anaplastic Astrocytoma, Medulloblastoma
- Trial name
- NCT01861990
- Testing
- Valproic Acid
- Where
- United States
- Sponsor
- Medical University of South Carolina
Neurosciences, MRI
OPTIMIZATION of ADVANCED MR SEQUENCES
This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to…
- Conditions
- Neurosciences, MRI, Brain Tumor, Mental Disorders
- Trial name
- OPT-IRM (NCT05618990)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
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