Clinical trials: Neoplasm, Uterine
Non-Small Cell Lung Cancer, Small Cell Lung Cancer
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
QUILT-3.055 is a Phase 2b, open-label, multicohort study investigating combination immunotherapies in patients with advanced solid tumors who have previously been treated with PD-1/PD-L1 checkpoint inhibitors.
- Conditions
- Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT03228667
- Testing
- N-803 + Pembrolizumab, N-803 + Nivolumab, N-803 + Atezolizumab
- Where
- 35 sites in United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
Advanced Solid Tumors
CVL237 Tablets in the Treatment of Advanced Solid Tumors With PTEN Deficiency
This is a single-arm, open-label, multicenter, phase II study of CVL237 tablets in the treatment of advanced solid tumors with PTEN deficiency.
- Trial name
- NCT06183736
- Testing
- CVL237 tablets
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Convalife (Shanghai) Co., Ltd.
Endometrial Cancer
An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial Cancer
This is an open-label, multi-center, single-arm, two-period Phase 2 study. The study will investigate the efficacy of Sodium Cridanimod in conjunction with progestin therapy in a population of subjects with recurrent or…
- Trial name
- NCT03077698
- Testing
- Sodium Cridanimod, progestin therapy
- Where
- 25 sites in United States
- Volunteers
- 25 people
- Sponsor
- Xenetic Biosciences, Inc.
Stomach Cancer, Esophageal Cancer
Comparison of Standard of Care or Treatment on Protocol
Patient will choose to either receive the standard of care according to National Comprehensive Cancer Network (NCCN) or approved guidelines for their condition or to be treated according to one arm of the protocol that they could…
- Conditions
- Stomach Cancer, Esophageal Cancer, Bladder Cancer, Skin Cancer
- Trial name
- NCT01010334
- Testing
- standard of care
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New Mexico Cancer Research Alliance
Carcinoma, Endometrioid, mTOR Protein
POEM STUDY: A Phase IIa Trial in Endometrial Carcinoma With Temsirolimus
Type of Application: Clinical trial of new indication. Experimental drug: The study dose of temsirolimus will be 25 mg administered intravenously, infused over a 30- to 60-minute period once weekly for 28 days (Total doses: 4…
- Trial name
- POEM (NCT02093598)
- Testing
- Temsirolimus
- Where
- 3 sites in Spain
- Volunteers
- 10 people
- Sponsor
- MedSIR
Womens Health, Cervical Dysplasia
Effectiveness of a Vaginal Gel on CIN1/2 Regression and HPV Clearance.
The goal of this clinical trial is to evaluate whether a Coriolus versicolor-based vaginal gel facilitates HPV clearance in women aged 30-50 years diagnosed with HPV and CIN1 or CIN2.
- Conditions
- Womens Health, Cervical Dysplasia, Cervical Intraepithelial Neoplasia (CIN), Non-invasive Treatment
- Trial name
- NCT07429071
- Testing
- Papilocare Vaginal Gel
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- University of Aarhus
Endometrial Cancer
The Role of Hypoxia as a Selective Pressure for TP53 Mutations
The study aims to develop scans that tell the investigators about the oxygen content of tumours using Magnetic Resonance Imaging (MRI) and seeing whether regions of low oxygen content are related to mutations in cancer genes such…
- Trial name
- NCT03466034
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cervical Cancer
Prospective Evaluation of Intrafractional and Interfractional Cervical Motion During External Beam Radiation for Intact Cervical Cancer by the Calypso® 4D Localization System™
The purpose of this study is to find out how the cervix normally moves during radiation treatment. This study will also evaluate how cervical cancer shrinks during chemotherapy and radiation.
- Trial name
- NCT00907634
- Sponsor
- Emory University
Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus
Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.
- Conditions
- Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling, Prognosis
- Trial name
- NCT04276532
- Testing
- sentinel lymph node sampling (SLN), pelvic lymphonodectomy (PLN)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Xiaojun Chen
Metastatic Malignant Neoplasm
A Study of NPX267 for Subjects With Solid Tumors Known to Express HHLA2/B7-H7
NPX267 is an antibody drug targeting the inhibitory receptor for B7-H7 (HHLA2) which may control evasion of the immune response in tumors.
- Trial name
- NCT05958199
- Testing
- NPX267
- Where
- 7 sites in United States
- Volunteers
- 131 people
- Sponsor
- NextPoint Therapeutics, Inc.
Polycystic Ovary Syndrome
Uterine Artery Blood Flow in Pregnant Women With PCOS Treated With Metformin
FlowMet study is a "sub-study" of the PregMet study (registered in 2005). The aim of the FlowMet study is to register the possible effect of metformin on the blood flow of the uterine artery in pregnant PCOS women.
- Trial name
- FlowMet (NCT00466622)
- Testing
- Metformin
- Where
- Norway
- Volunteers
- 48 people
- Sponsor
- Norwegian University of Science and Technology
Fibroid Uterus, Gynecologic Disease
Carboprost (Hemabate) for Fibroid Resection
The purpose of this research study is to determine if low-dose (i.e., a fraction of what is commonly used) carboprost (Hemabate) helps facilitate fibroid removal (myomectomy).
- Conditions
- Fibroid Uterus, Gynecologic Disease, Leiomyoma, Uterine
- Trial name
- NCT05518812
- Testing
- Carboprost Tromethamine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Cervical Cancer
Topotecan, Cisplatin, and Radiation Therapy in Treating Patients With Advanced Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as topotecan and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00287911
- Testing
- cisplatin, topotecan hydrochloride, brachytherapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Endometrial Adenocarcinoma, Metastatic Endometrial Cancer
Assessing Survival Outcomes With Checkpoint Inhibition ExteNded vs Discontinued in Endometrial Cancer
This is a pragmatic, non-inferiority randomized hybrid decentralized clinical trial. The goal of this study is to determine if one year of maintenance immunotherapy (anti-PD1 agent therapy; pembrolizumab or dostarlimab) is…
- Conditions
- Endometrial Adenocarcinoma, Metastatic Endometrial Cancer, Endometrial Cancer, Recurrent Endometrial Cancer
- Trial name
- ASCEND-EC-DCT (NCT07867002)
- Testing
- anti-PD1 agent therapy - 1 year, anti-PD1 agent therapy - 2 years
- Where
- 6 sites in United States
- Volunteers
- 140 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrial Cancer
Study of EV for Recurrent Endometrial Carcinoma
This study is testing a drug called enfortumab vedotin in up to 12 patients with advanced endometrial (uterine) cancer that has worsened after previous treatments, including immunotherapy.
- Trial name
- EV-4-EC (NCT07139977)
- Testing
- Enfortumab Vedotin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- William Bradley
Cervical Cancer
Innovation for Standard Identification of Insertional HPV Mutations and of Target Therapeutic Genes in Cervical Cancer: Towards Development of Personalized Biomarkers in Clinical Oncology (PAIR HPV)
Quantification and follow-up of circulating tumoral DNA in serum and/or plasma of patients with cervical cancer compared to the early detection of minimal metastatic disease.
- Trial name
- PAIR HPV (NCT02554565)
- Testing
- Tumor biopsy, Blood sampling
- Where
- 4 sites in France
- Volunteers
- 26 people
- Sponsor
- Institut Curie
Endometrial Carcinoma
Effect of Curcumin Addition to Standard Treatment on Tumour-induced Inflammation in Endometrial Carcinoma
This therapy aims to determine whether curcumin can inhibit tumor induced inflammation in patients with endometrial carcinoma. In addition, curcumin could possibly induce a better functioning of chemotherapy and a decrease in…
- Trial name
- NCT02017353
- Testing
- Curcuphyt
- Where
- Belgium
- Volunteers
- 7 people
- Sponsor
- University Hospital, Gasthuisberg
Cervical Cancer
Inactivated KAWAI Bacteria for Diarrhea Prevention During Pelvic Radiotherapy in Postoperative Cervical Cancer
This is a multicenter, randomized, double-blind, placebo-controlled study. The purpose of this study is to evaluate whether an oral probiotic supplement (KAWAI inactivated bacteria) can reduce the side effects (especially…
- Trial name
- NCT07900477
- Testing
- KAWAI powder
- Volunteers
- 100 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Cervical Neoplasm, Adaptive Radiotherapy
Moderately Hypofractionated Adaptive Radiotherapy for Cervical Cancer
External radiation given in 25 fractions or so together with weekly chemotherapy and followed by 5 or 6 fractions of brachytherapy is the standard of care for patients with locally advanced cervical cancer.
- Conditions
- Cervical Neoplasm, Adaptive Radiotherapy, Radiotherapy; Adverse Effect
- Trial name
- NCT05994300
- Testing
- Moderately hypofractionated adaptive radiotherapy (ART)+ High-dose rate (HDR) Brachytherapy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Ovarian Cancer, Cervical Cancer
Sirius in Gynaecological Laparoscopic Surgery
Precision Robotics' Sirius Robotic Flexible Endoscopic System is a new fully integrated compact 3D laparoscopic camera system with a disposable single-use flexible tip that can change its viewing direction.
- Conditions
- Ovarian Cancer, Cervical Cancer, Gynecologic Cancer
- Trial name
- NCT05048407
- Testing
- Gynaecological laparoscopic surgery (Sirius System)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Precision Robotics (Hong Kong) Limited
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