Clinical trials: Neoplasm Recurrence
Postoperative Pain, Recurrence
Desarda Repair Compared to Lichtenstein Repair for the Treatment of Inguinal Hernias
The Lichtenstein technique for hernia repair is safe and simple, but the underlying mesh prosthesis has its setbacks, as it acts as a mechanical barrier5.
- Conditions
- Postoperative Pain, Recurrence, Wound Complication
- Trial name
- NCT04850131
- Testing
- Desarda repair
- Where
- Pakistan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Benazir Bhutto Hospital, Rawalpindi
Breast Cancer, Fear of Cancer
Targeted eHealth Intervention to Reduce Fear of Recurrence Among Breast Cancer Survivors
The FoRtitude trial aims to evaluate an eHealth intervention designed to teach breast cancer survivors strategies to manage anxiety about cancer recurrence.
- Trial name
- FoRtitude (NCT03384992)
- Testing
- Diaphragmatic breathing and relaxation, Cognitive restructuring, Scheduled worry practice
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Primary Immune Deficiency Diseases
Evaluate Bacteriophage as a Useful Immunogen in Patients With Primary Immune Deficiency Diseases (PIDD)
This protocol is designed to ascertain whether the bacteriophage 0X174 neoantigen is safe and effective as an antigen used in the evaluation of primary and secondary immune responses.
- Trial name
- Bacteriophage (NCT01617122)
- Testing
- Bacteriophage OX174
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Breast Cancer
Study on Early Auxiliary Diagnosis and Postoperative Recurrence Monitoring of Breast Cancer
This study screened and identified effective methylation markers in breast cancer, established a detection system for early screening and early diagnosis, and provided a research basis for the embryonic form of non-invasive…
- Trial name
- NCT05858242
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Breast Cancer, Colorectal Cancer
UMCC 003 Cancer-Related Protein Biomarkers in Blood and Tumor Tissue of Patients With Cancer
RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer and blood from healthy participants may help doctors learn more about changes that may occur in DNA and identify biomarkers related…
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Liver Cancer
- Trial name
- IRB 2000-294 (NCT00900094)
- Testing
- fluorescence in situ hybridization, polymerase chain reaction, protein expression analysis
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Recurrent Pilonidal Sinus Disease
Limberg and Karydakis Flap in Recurrent Pilonidal Sinus Disease
It was investigated whether there is a factor that can aid determination of the preferred technique by comparing the early Limberg flap and Karydakis procedure techniques for the treatment of recurrent pilonidal sinus.
- Trial name
- NCT02287935
- Testing
- Limberg flap, Karydakis procedure
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Adana Numune Training and Research Hospital
Kidney Cancer
DNA Variations in the Gene in Young Patients With Wilms' Tumor
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00088803
- Testing
- molecular genetic technique, polymerase chain reaction, polymorphism analysis
- Where
- 232 sites in United States, Australia and 5 more
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Cancer Patients
Exploration of Management Model and Intervention Research on Fear of Cancer Recurrence
1. Through cross-sectional investigation and research, construct an fear of cancer recurrence warning model to identify and screen high fear of cancer recurrencecancer populations, in order to identify predictive factors for high…
- Trial name
- NCT05922423
- Testing
- MBSR, health education
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Nondependent Opioid Abuse, Episodic
Abuse Potential of Orally Administered Crushed Embeda Compared to Crushed Controlled-Release Morphine and Placebo in Non-Dependent Recreational Opioid Users
The primary purpose of this study is to determine the abuse potential of EMBEDA compared to controlled release morphine when crushed and taken orally by non-dependent recreational opioid users; secondary purposes include to…
- Trial name
- NCT01380093
- Testing
- MS Contin (morphine sulfate, controlled release), EMBEDA (morphine sulfate / naltrexone hydrochloride)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pfizer
Orthodontic Retention
Eight Units Extended Maxillary Fixed Retainer
Assessment of dental changes associated with an eight-unit extended maxillary fixed retainer in 3D. monitoring PDL response and evaluation of patient's satisfaction ,quality of life and speech with extended maxillary fixed…
- Trial name
- Extended FR (NCT05889884)
- Testing
- Extended maxillary fixed retainer
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Major Depressive Disorder, Recurrent
Investigation of Brain Network Dynamics in Depression
This research study is being done to gain a better understanding about brain networks that may be involved in depression. The investigators plan to examine how these networks change after the brain is stimulated with…
- Trial name
- NCT01931995
- Testing
- TMS positively correlated DLPFC, TMS to negatively correlated DLPFC
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Relapse
Comparison of Retention Characteristics of Immediate vs Delayed Retainer Delivery Using 3D Digital Model Analysis
Retention has been defined as "the holding of teeth following orthodontic treatment in the treated position for the period of time necessary for the maintenance of the result".
- Trial name
- NCT06292364
- Testing
- immediate orthodontic retainer delivery, delayed orthodontic retainer delivery
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage I Squamous Cell Carcinoma of the Oropharynx
Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors
This pilot clinical trial studies freeze-dried black raspberries (BRB) in preventing oral cancer recurrence in high at-risk Appalachian patients previously treated with surgery for oral cancer.
- Conditions
- Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage I Squamous Cell Carcinoma of the Oropharynx, Stage I Verrucous Carcinoma of the Oral Cavity, Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT01504932
- Testing
- BRB Lozenge, Survey Administration, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer, Colorectal Cancer
Family Quality of Life Among Families With a Member Who is a Cancer Patient
RATIONALE: Developing a questionnaire that can be used to assess the quality of life among people who have a family member with cancer may help the study of cancer in the future.
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00544336
- Testing
- questionnaire administration, survey administration, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Benign Paroxysmal Positional Vertigo, Vitamin D
Evaluation of the Efficacy of Vertistop® D and Vertistop® L in the Prevention of BPPV Recurrence
The study involves the evaluation of 3 groups of subjects (3-arm study). Patients diagnosed with BPPV and "sufficient" serum concentrations of Vitamin D (>30 ng/mL, >75 nmol/L) at baseline may be treated with 2 tablets per day…
- Conditions
- Benign Paroxysmal Positional Vertigo, Vitamin D, Antioxidants
- Trial name
- NCT05748249
- Testing
- Vertistop® D
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Giant Cell Tumor of Bone
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location.
- Trial name
- NCT03295981
- Testing
- Zoledronic Acid
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Recurrent Medulloblastoma
Apatinib Combined with Temozolomide and Etoposide Capsules in the Treatment of Recurrent Medulloblastoma in Children
This study is a prospective single-center clinical study, which aims to observe and evaluate the efficacy and safety of apatinib combined with temozolomide and oral etoposide in the treatment of recurrent medulloblastoma in…
- Trial name
- NCT04501718
- Testing
- Apatinib Combined With Temozolomide and Etoposide Capsules
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Beijing Sanbo Brain Hospital
Tobacco Use Cessation, Sleep Disorders
Impact of Smoking Cessation on Sleep - 5
Smoking is a major health problem with a direct link to elevated heart- and lung-related problems. Nicotine is highly addictive, which makes quitting difficult and relapse after quitting highly probable.
- Trial name
- NCT00132821
- Testing
- Bupropion, Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Uterine Fibroid
Life Study: Lifestyle Intervention in Fibroid Elimination
The study will evaluate a lifestyle, nutrition, and exercise program to assess whether this program is acceptable and feasible for patients..Researchers will examine if the LIFE program can modify fibroid recurrence.
- Trial name
- NCT05416424
- Testing
- LIFE program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hemoptysis
Chinese Hemoptysis Registry Study
This is a prospective, multicenter, observational registry study of hemoptysis in China. Hospitalized patients with active hemoptysis who undergo vascular interventional diagnosis and therapy will be consecutively enrolled from…
- Trial name
- CHORE (NCT07833878)
- Testing
- Not applicable. This is an observational patient registry. All clinical procedures (including bronchial artery embolization) are part of routine medical care and are not assigned as study intervention
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Qiu Jipeng