Clinical trials: Neoplasm of Lung
Lung Cancer
Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy
The aim of the study is to assess the performance of Aquyre Biopsy Scanner technology (the FDA class I medical device) at determining if tissue from the lymph nodes and lung nodules, taken during a bronchoscopy procedure, is…
- Trial name
- NCT05393154
- Testing
- Biopsy Adequacy Evaluation by Aquyre Biopsy Scanner
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Aquyre Bioscience, Inc
EGFR Mutant Advanced Non-small Cell Lung Cancer, Central Nervous System (CNS) Metastases
Material Balance of [14C]Zorifertinib in Healthy Adult Male Participants in China
This is a single-center, single-dose, open-label, Phase I study to evaluate the mass balance, biotransformation, pharmacokinetic characteristics, excretion pathways, and safety of a single oral 200 mg/5 µCi dose of…
- Trial name
- NCT07620951
- Testing
- [14C]Zorifertinib Oral Formulation
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Alpha Biopharma (Jiangsu) Co., Ltd.
Lung Cancer
A Single-Dose,ComparativeBioavailability Study ofTwo Formulations ofErlotinib150mgTabletsunderFastingConditions
Theobjectiveofthisstudyistoevaluatethecomparativebioavailabilitybetween: ErlotinibHCl150mgTablets(Novopharm Limited,Canada)and Tarceva® 150mgTablets(Hoffmann-LaRocheLimited,Canada)…
- Trial name
- NCT04145570
- Testing
- Erlotinib HCl 150 mg, Tarceva®
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Quadras Scientific Solutions
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
High Risk Cancer
Standalone Observational Study Assessing the Performance of an AI/ML Tech-based SaMD on Chest LDCT Images (REALITY)
This is a Multinational, Multicenter, retrospective study for the evaluation of the standalone efficacy and safety of an Artificial Intelligence/Machine Learning (AI/ML) technology-based end-to-end Computer assisted…
- Trial name
- REALITY (NCT06576232)
- Testing
- Median LCS
- Where
- 5 sites in United States, Spain
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Median Technologies
Bronchiectasis Adult, Mediastinal Lymphadenopathy
Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound
The purpose of this study is to assess if there is decrease in cough during flexible bronchoscopy and endobronchial ultrasound when different modes of lidocaine administration are used.
- Conditions
- Bronchiectasis Adult, Mediastinal Lymphadenopathy, Pneumonia, Chest--Diseases
- Trial name
- NCT03829618
- Testing
- Topical lidocaine, Nebuliser solution, Nebuliser Suspension
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Asthma
University of Wisconsin Severe Asthma Research Program III
The overall goal of this proposal is to better understand the basis of structural airway changes in severe asthma and how asthma exacerbations may contribute to their progression over time.
- Trial name
- NCT01760915
- Testing
- NC100182 Hyperpolarized 3He
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
NSCLC
Circulating Fibrocytes in Non-small Cell Lung Cancer.
The investigators will collect fibrocytes (CD45+Col-1+) in patients with non-small cell lung cancer (NSCLC). The investigators hypothesize that patients with NSCLC experience expansion of immunosuppressive fibrocytes, which are…
- Trial name
- NCT01998425
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Lung Cancer
LC-NMR Study Biomarkers to Detect Lung Cancer
Lung cancer is the most common cancer in men and the fourth most common cancer in women worldwide. Until today no effective method permits the early detection of lung cancer.
- Trial name
- NCT02024113
- Testing
- Venous blood sample
- Where
- 2 sites in Belgium
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Lung Cancer (NSCLC)
Construction and Empirical Study of Indirect Intervention Model for Protective Medical Lung Cancer Patients Based on Family System Theory
To clarify the irrational cognition of family caregivers of lung cancer patients at various perioperative stages under the background of protective medical treatment, construct an indirect intervention model for lung cancer…
- Trial name
- FST (NCT07749443)
- Testing
- Caregiver cognitive intervention based on printed handbook, Graded information disclosure strategies, Routine perioperative health education
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Dementia, Diabetes Mellitus
Impact of Lifestyle Modification on the Development of Dementia, Chronic Kidney Disease, Diabetes, Chronic Obstructive Pulmonary Disease, Cancers and Cardiovascular Disease in a Thai General Population
This is a community-based cluster randomized control trial aimed to investigate the impact of lifestyle modification (diet, physical activity, alcohol drinking and smoking) on the development of dementia, diabetes, chronic kidney…
- Conditions
- Dementia, Diabetes Mellitus, Chronic Kidney Disease, Cardiovascular Diseases
- Trial name
- NCT02967406
- Testing
- 4 x 4 lifestyle modification
- Where
- Thailand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Prostate Cancer, Breast Cancer
Collection of Blood From Patients With Cancer
This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy.
- Conditions
- Prostate Cancer, Breast Cancer, Colon Cancer, Lung Cancer
- Trial name
- NCT00034216
- Where
- United States
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Postoperative Pain
Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy
Investigators have designed a randomized controlled trial. Utilizing an open-label, randomized, controlled study methodology, this trial aims to explore a opioid-free, safe, and effective analgesic approach for thoracic surgery.
- Trial name
- NCT06570538
- Testing
- Ropivacaine, Sufentanil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Critical Illness, Chronic Obstructive Lung Disease
Advance Care Planning Evaluation in Hospitalized Elderly Patients
The purpose of the study is to inform decision-makers of the best strategies to implement advanced care planning (ACP). An advanced care plan (ACP) is a verbal or written instruction describing what kind of care an individual…
- Conditions
- Critical Illness, Chronic Obstructive Lung Disease, Congestive Heart Failure, Cirrhosis
- Trial name
- ACCEPT (NCT01362855)
- Where
- 9 sites in Canada
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Daren K. Heyland
Non-small Cell Lung Cancer
Effects of Essential Amino Acid Intake on Net Protein Synthesis in Weight-losing Non-small Cell Lung Cancer Patients
Weight loss commonly occurs in lung cancer patients, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01172314
- Testing
- EAA+LEU vs total AA, Total AA vs EAA+LEU
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Nonsquamous Nonsmall Cell Neoplasm of Lung
Evaluate the Safety and Efficacy of BLEX 404 Oral Liquid Combined With Pemetrexed + Cisplatin Therapy
Maitake is reported with immunomodulatory functions against tumor growth in terms of its unique molecular structure, β-glucan polysaccharides within 1, 6 main chain having 1, 3 branches and a 1, 3 main chain having 1, 6 branches…
- Trial name
- NCT05764928
- Testing
- BLEX 404
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rgene Corporation
NSCLC Stage IV
Biomarkers to Predict the Response to Pembrolizumab in Chinese NSCLC Patients
Pembrolizumab is approved for advanced stage non-small cell lung cancer. However, the response rate is low (around 10-15 %) in patients treated in Macau SAR, China.
- Trial name
- NCT04076228
- Testing
- Pembrolizumab
- Where
- China
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kiang Wu Hospital
Non-Small Cell Lung Cancer, KRAS Mutation-Related Tumors
Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer
This study will evaluate using hydroxychloroquine (HCQ) along with binimetinib as an effective method for treating cancer. All patients will receive binimetinib at a standard dose approved for other cancers.
- Trial name
- NCT04735068
- Testing
- Binimetinib Pill, Hydroxychloroquine Pill
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung Cancer, Breast Cancer
Distinction Between Lung Cancer and Gynecological Cancers by Canine Scent Detection
Previous studies have shown that specially trained sniffer dogs are capable to discriminate breath samples of patients with lung cancer and healthy individuals.
- Conditions
- Lung Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT01383408
- Testing
- exhalation analysis of breath sample
- Where
- 2 sites in Germany
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- Schillerhoehe Hospital
ER Stress,, Chronic Airway Disorders,
Endoplasmic Reticulum Stress in Chronic Respiratory Diseases
Aim: To investigate whether ER stress is implicated in the pathogenesis of various pulmonary disorders Measurement: 1. Unfolded protein responses (UPRs) in blood (PBMCs)of patients 1. CHOP 2. GRP 78 and so on 2.
- Conditions
- ER Stress,, Chronic Airway Disorders,, Lung Cancer,, Interstitial Lung Diseases
- Trial name
- NCT01211015
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University