Clinical trials: Neoplasms, Pharyngeal
Cancer
External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Indinavir and ritonavir may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00637637
- Testing
- indinavir sulfate, ritonavir, radiation therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Oncology Institute of Southern Switzerland
Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage II Squamous Cell Carcinoma of the Oropharynx
Erlotinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Mouth or Throat Cancer
Phase I trial to study the effectiveness of combining erlotinib with radiation therapy with or without cisplatin in treating patients who have advanced mouth or throat cancer.
- Conditions
- Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage II Squamous Cell Carcinoma of the Oropharynx, Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage III Squamous Cell Carcinoma of the Oropharynx
- Trial name
- NCT00049166
- Testing
- erlotinib hydrochloride, cisplatin, intensity-modulated radiation therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Adenoid Hypertrophy, Tonsillar Hypertrophy
Full-wrap Versus Conventional Suspension for Reducing Soft Palate Injury Rate in Transoral Surgery
This study aims to evaluate whether the use of full-wrap suspension, compared with the traditional double-strap suspension, can effectively reduce the risk of intraoperative and postoperative soft palate injury in…
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Nasopharyngeal Diseases, Nasopharyngeal Tumors
- Trial name
- NCT07552545
- Testing
- Intraoperative soft palate suspension using the double-strap method., Intraoperative soft palate suspension using the full-wrap method.
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma (NPC)
Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and Immunotherapy
To explore the efficacy and safety of reduced-dose radiotherapy combined with concurrent chemotherapy and immunotherapy in stage Ⅳa (AJCC 8th,) locally advanced nasopharyngeal carcinoma patients who are sensitive to induction…
- Trial name
- NCT07328841
- Testing
- Full course of PD-1blockades, Cisplatin-based induction chemotherapy, Standard-dose radiotherapy
- Where
- 12 sites in China
- Volunteers
- 456 people
- Sponsor
- Ming-Yuan Chen
Nasopharyngeal Cancer Recurrent, Nasopharyngeal Cancinoma (NPC)
Perioperative Chemotherapy and Immunotherapy for Locally Recurrent Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is an endemic malignancy in Southern China and southeast Asia. Despite intensive radical therapy, between 15% and 30% of NPC patients develop relapse.
- Trial name
- NCT07129772
- Testing
- Gemcitabine (GEM), Cisplatin, PEMBROLIZUMAB (alone or when added to a regimen above)
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- The University of Hong Kong
Cervical Cancer, Colorectal Cancer
89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
A prospective, open-label, phase 2 study to explore CAIX expression through 89Zirconium-labelled girentuximab deferoxamine (89Zr-girentuximab) PET/CT imaging in patients with solid tumors.
- Conditions
- Cervical Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- STARBURST (NCT05563272)
- Testing
- 89Zr-girentuximab for PET/CT imaging of CAIX positive tumors
- Where
- 10 sites in United States
- Volunteers
- 11 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Ltd
Nasopharyngeal Carcinoma, Neoadjuvant Chemotherapy
A Multicenter, Prospective, Phase III Randomized Controlled Clinical Study for the Treatment of N2-3 Nasopharyngeal Carcinoma Patients
At the initial diagnosis of locally advanced nasopharyngeal carcinoma, a considerable proportion of patients have developed distant metastasis, forming subclinical lesions.
- Trial name
- NCT04061278
- Testing
- 4 cycles of Neoadjuvant Chemotherapy With Definitive Radiotherapy, 3 cycles of Neoadjuvant Chemotherapy With concurrent chemoradiotherapy
- Where
- 12 sites in China
- Volunteers
- 246 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004901
- Testing
- ethynyluracil, fluorouracil, hydroxyurea
- Where
- 2 sites in United States
- Sponsor
- Robert H. Lurie Cancer Center
Nasopharyngeal Carcinoma (NPC)
RAIRI Model-Guided Adjuvant Therapy in Nasopharyngeal Carcinoma
This study aims to evaluate a personalized approach for treating patients with locoregionally advanced nasopharyngeal carcinoma (NPC).
- Trial name
- RAIRI-NPC (NCT07590024)
- Testing
- PD-1 inhibitor, Capecitabine
- Where
- China
- Volunteers
- 651 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Dysphagia, Esophageal Cancer
Focal Cryoballoon Ablation for Malignant Dysphagia
Rationale: Dysphagia is commonly encountered in patients with esophageal carcinoma who are no candidates for treatment with curative intent. It often has a considerable impact on quality of life and can cause malnourishment.
- Conditions
- Dysphagia, Esophageal Cancer, Cryotherapy
- Trial name
- DYS-CBAS (NCT06618742)
- Testing
- Cryotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Laura Boer
Squamous Cell Carcinoma of the Oral Cavity and Oropharynx
A Study Evaluating the Contribution of Non-Coplanar Beam Arrangement in Reducing Toxicity in Radiotherapy for Upper Aerodigestive Tract Cancers
Cancers of the upper aerodigestive tract (UADT) are frequently treated with external beam radiotherapy, either alone or in combination with chemotherapy.
- Trial name
- BaReTox (NCT07413627)
- Testing
- Coplanar External Beam Radiotherapy, Non-Coplanar External Beam Radiotherapy
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Georges Francois Leclerc
Dysphagia
Pharyngocise Dose Response Study
In this study supported by an American Cancer Society grant, the investigators are evaluating two levels of swallowing exercise intensity on the maintenance of swallowing muscles and their function in Head/Neck cancer patients…
- Trial name
- NCT01279837
- Testing
- Pharyngocise
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Florida
Nasopharyngeal Carcinoma
Hippocampus Avoidance During Intensity Modulated Radiotherapy for T4 Nasopharyngeal Carcinoma Patients
This is a prospective, non-randomized phase III study observing the cognitive function changes with conformal hippocampus avoidance during intensity modulated radiotherapy for T4 nasopharyngeal carcinoma patients.
- Trial name
- NCT03411954
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Head and Neck Squamous Carcinoma, Nasopharyngeal Carcinoma
Trial of E10A in Head and Neck Cancer
Angiogenesis, the formation of new blood vessel from existing vessels, is essential for tumor growth and metastasis. Antiangiogenic therapies inhibit the growth of genetically stable endothelial cells, and most tumors should…
- Trial name
- NCT00634595
- Testing
- E10A, Cisplatin, Paclitaxel
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma, Intensity-Modulated Radiotherapy
Reducing High Risk Primary Tumor Clinical Target Volumes (CTVp1) in Non-metastatic Nasopharyngeal Carcinoma
To evaluate the long-term local control, survival rate, acute and late radiation related toxicities, quality of life after reducing high risk primary tumor clinical target volumes (CTVp1) in non-metastatic nasopharyngeal…
- Trial name
- CTVp1-NPC (NCT05994170)
- Testing
- Reduction CTVp1, Non-reduction CTVp1
- Where
- China
- Volunteers
- 454 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Drug Use for Unapproved Schedule
EBV Positive Nasopharyngeal Carcinoma Treated With Concurrent Chemo-radiotherapy With or Without Anti-Viral Drug
PCR-DNA of EBV test is a good prognostic indicator for survival after treatment (report: Prognostic Impact of Plasma, Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Treated using Intensity-Modulated Radiation…
- Trial name
- NCT03656965
- Testing
- Acyclovir 800 MG, Radiotherapy and chemotherapy
- Where
- Kuwait
- Volunteers
- 50 people
- Sponsor
- Kuwait Cancer Control Center
Carcinomas, Squamous Cell, Dysphagia
A Pilot Study of Acupuncture Treatment for Dysphagia
The current standard of care for advanced HNC is concurrent chemoradiation therapy (CRT), which has led to increased survival rates, but with significant acute and long-term toxicities.
- Trial name
- NCT00797732
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Dana-Farber Cancer Institute
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus-Related Neck Squamous Cell Carcinoma of Unknown Primary
Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial
This phase II trial tests how well lovastatin and pembrolizumab work in treating patients with head and neck cancer that has come back after a period of improvement (recurrent) or that has spread from where it first started…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus-Related Neck Squamous Cell Carcinoma of Unknown Primary, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma
- Trial name
- NCT06636734
- Testing
- Biospecimen Collection, Computed Tomography, Lovastatin
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Emory University
Nasopharyngeal Carcinoma
Concurrent Docetaxel Plus Cisplatin or Cisplatin Alone With IMRT in High Risk Nasopharyngeal Carcinoma
The investigators aim to evaluate the efficiency and toxicities of concurrent docetaxel and cisplatin with intensity-modulated radiotherapy in high risk locoregionally advanced nasopharyngeal carcinoma.
- Trial name
- NCT02610556
- Testing
- Cisplatin 2, Docetaxel, Cisplatin 1
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Sun Yat-sen University
Head and Neck Squamous Cell Carcinoma
BH4 in the Prevention and Treatment of Radiation-induced Skin Reactions for Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma)
Head and neck squamous cell carcinoma (include nasopharyngeal carcinoma) is one of the most common malignant tumor in China, and radiotherapy is the main treatment method.
- Trial name
- NCT05299203
- Testing
- Sapropterin dihydrochloride tablets
- Volunteers
- 18 people
- Sponsor
- West China Hospital
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