Clinical trials: Neoplasms, Prostate
Erectile Dysfunction, Prostate Cancer
Erectile Recovery After Robotic-Assisted Laparoscopic Prostatectomy
The study is a prospective, randomized, double-blind, placebo-controlled drug study to evaluate the pattern of erectile function recovery after robotic assisted laparoscopic prostatectomy (RALP).
- Trial name
- NCT03406169
- Testing
- Sildenafil 25 MG Oral Tablet, Pentoxifylline
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Prostate Cancer
Prostate Testing for Cancer and Treatment
RATIONALE: Radical prostatectomy is surgery to remove the entire prostate. Radiation therapy uses high-energy x-rays or other types of radiation to kill tumor cells. Sometimes the tumor may not need treatment until it progresses.
- Trial name
- ProtecT (NCT02044172)
- Testing
- Radical prostatectomy, Conformal radiation therapy, Active monitoring
- Where
- 8 sites in United Kingdom
- Volunteers
- 82,849 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Prostate Cancer
Prophylactic Vs. Therapeutic Use of Uroxatrol in Men Undergoing Brachytherapy
To asess the efficacy of Uroxatrol, an alpha blocker in men undergoing prostate brachytherapy to treat prostate cancer, and whether the use of Uroxatrol in advance of the brachytherapy is better or not than starting it on the day…
- Trial name
- NCT00201630
- Testing
- Uroxatrol (drug)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- New York Prostate Institute
Prostate Neoplasm
Prostate Cancer Screening Trial Using Imaging
Participants will be recruited from the community and attend a screening clinic and undergo the following screening tests: 1. Bi-parametric MRI - reported by a radiologist and CAD-AI system 2.
- Trial name
- PROSTAGRAM (NCT03702439)
- Where
- United Kingdom
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Prostate Cancer, PET/CT
Head-to-head Comparison of [68Ga]Ga-PSMA-D5 With [68Ga]Ga-PSMA-11 PET/CT in PCa Diagnosis, Recurrence, and Metastasis
To prospectively evaluate the radiodrug biodistribution of a novel PET imaging agent [68Ga]Ga-PSMA-D5 in different organs of prostate cancer patients and its diagnostic efficacy in the diagnosis, recurrence and metastasis of…
- Trial name
- NCT05955677
- Testing
- [68Ga]Ga-PSMA-D5, [68Ga]Ga-PSMA-11
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Brain Cancer, Breast Cancer
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types.
- Conditions
- Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- CAMPERR (NCT05366881)
- Where
- 17 sites in United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Adela, Inc
Prostate Neoplasm
Improvements in Dynamic Contrast-Enhanced MR Angiography and Perfusion and Non-Contrast MRI
This study evaluates if technical improvements in MRI can be used to provide improved performance contrast-enhanced MRI as used for angiography and perfusion as well as in non-contrast MRI.
- Trial name
- NCT06315595
- Testing
- Non-Interventional Study
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prostate Cancer
Prostate Cancer Parameters for Patients Receiving Proton Treatment
To prospectively collect data from patients treated with proton therapy for prostate cancer using the IUHPTC technique for the evaluation of toxicity and efficacy of this treatment technique.
- Trial name
- NCT02110849
- Testing
- Proton
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Prostate Cancer
Anesthesia in PROstate Biopsy Pain Obstruction Study
This is a multicentre randomized controlled trial in comparison of the perineal nerve block approach between the periprostatic block in the pain control in men undergo a transperineal prostate biopsy.
- Trial name
- APROPOS (NCT04501055)
- Testing
- perineal nerve block, periprostatic block
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital
Prostate Cancer
Immuno-molecular Approaches for Non-invasive Diagnosis of Prostate Cancer
The purpose of this study is to isolate and characterize tumor cells non-invasively from biological samples in patients with prostate cancer and demonstrate the ability to identify the presence and number of tumor cells before…
- Trial name
- PROSTA-PAP (NCT04702633)
- Testing
- Results obtained by biopsy and MRI results., Clinical data
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostatic Neoplasms
Evaluation of Safety and Efficacy of Estetrol in Healthy Men
The current study is designed as a phase Ib multiple dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of E4 in healthy men after daily oral administration for 28 days.
- Trial name
- NCT02718378
- Testing
- estetrol
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pantarhei Oncology B.V.
Breast Cancer, Colon Cancer
Partnership for Healthy Seniors
The Centers for Medicare and Medicaid Services (CMS) has awarded cooperative agreements to 6 sites from across the country (Salt Lake City, UT, Molokai, HI, Houston, TX, Newark, NJ, Detroit, MI, and Baltimore City) to participate…
- Conditions
- Breast Cancer, Colon Cancer, Rectum Cancer, Cervix Cancer
- Trial name
- NCT00379743
- Testing
- Health coordinator (or patient navigator), Educational materials only
- Where
- United States
- Volunteers
- 2,593 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Prostate Carcinoma
A Prospective, Single-centre，Single-blinded Study of PROUD for Prostate Carcinoma Diagnosis
Prostate carcinoma (PC) is common malignancy and is considered to be the highest incidence in the old males. The traditional diagnostic methods of PC present with some shortcomings.
- Trial name
- NCT04699344
- Testing
- The level of CNV
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Recurrent Prostate Cancer After Surgery
This Study is Evaluating a New Radiation Treatment Technique for Patients Who Have Had Prostate Cancer, Undergone Surgery for Cancer, and Then Have Evidence That Their Prostate Cancer Has Returned.
There is significant, proven use of radiation for recurrent prostate cancer after surgical resection. This treatment typically is delivered over seven and a half weeks of daily treatments, presenting a burden to patients and the…
- Trial name
- DASBRT-RPC (NCT05946824)
- Testing
- Daily-adaptive Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Prostate Cancer, Cancer
Adaptation of the American Cancer Society (ACS) Early Detection of Prostate Cancer Patient Decision Aid for Spanish Speaking Men
Objectives: The primary objective of this project is to develop and evaluate a Spanish-language slide set for administration in group settings, adapted from the content of the current guidelines and existing, self-administered…
- Trial name
- NCT01447186
- Testing
- Post-Test Questionnaire, Interviews, Focus Groups
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Impact of a Printed Decision Aid on Patients' Intent to Undertake Prostate Cancer Screening
Although the number of recommendations against systematic screening of prostate cancer, 70% of patients still request testing because they overestimate the benefits and are unaware of the limitations.
- Trial name
- PSAMG (NCT02156869)
- Testing
- Decision aid
- Where
- France
- Volunteers
- 1,170 people, healthy volunteers welcome
- Sponsor
- University Paris 7 - Denis Diderot
Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma
Technology-Enhanced Acceleration of Germline Evaluation for Therapy, TARGET Study
This trial performs user testing of a mobile-friendly patient history collection and genetic education tool to improve healthcare providers' understanding of prostate cancer genetic testing.
- Conditions
- Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8
- Trial name
- NCT04447703
- Testing
- Interview, Internet Based Intervention, Survey Administration
- Where
- 5 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8
rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance
This clinical trial evaluates whether positron emission tomography-magnetic resonance imaging (PET-MRI) using the radioactive drug radiohybrid prostate-specific membrane antigen (rhPSMA)-7.3 may help in detecting higher grade or…
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8, Stage IIB Prostate Cancer AJCC v8
- Trial name
- NCT05852041
- Testing
- Biopsy of Prostate, Decipher Prostate Cancer Test, Flotufolastat F-18 Gallium
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Prostate Cancer
Biparametric MRI in Prostate Cancer Screening: a Noninferior Randomized Controlled Study
This is a single centre non-inferiority randomized controlled trial in comparison of the bpMRI between the traditional pathway in prostate cancer screening
- Trial name
- NCT05025527
- Testing
- biparametric MRI (bpMRI), Prostate cancer antigen (PSA)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital
Prostate Cancer, Treatment
Comparison H-FIRE and Laparoscopic RP in Treating Men With Localized Prostate Cancer
This trial is comparing the functional and oncological outcomes in treating men with prostate cancer between high-frequency irreversible electroporation and laparoscopic radical prostatectomy.
- Trial name
- NCT04278261
- Testing
- Focal therapy(high-frequency irreversible electroporation), laparoscopic radical prostatectomy
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital