Clinical trials: Neoplastic Meningitis
Breast Cancer
Intrathecal Trastuzumab for Leptomeningeal Metastases in HER2+ Breast Cancer
The drug being studied is Trastuzumab, a medicine that is used to slow or stop the growth of cancerous tumors that are HER-2 positive.
- Trial name
- NCT01325207
- Testing
- Trastuzumab
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Northwestern University
Metastatic Breast Cancer, Carcinomatous Meningitis
Intrathecal Trastuzumab Administration in Metastatic Breast Cancer Patients Developing Carcinomatous Meningitis
The purpose of this study is: Phase I: To determine the Trastuzumab maximum tolerated dose (MTD) when weekly administrated by intrathecal or intraventricular route to reach a intra CSF target concentration (30 µg/mL) near the…
- Trial name
- HIT (NCT01373710)
- Testing
- Trastuzumab
- Where
- 10 sites in France
- Volunteers
- 34 people
- Sponsor
- Institut Curie
Leptomeningeal Metastasis, Non-small Cell Lung Cancer Stage IV
Intrathecal Double Checkpoint Inhibition
The objective of the present study is to determine the feasibility and to explore anti-tumor activity of intrathecal double immune checkpoint inhibition for patients with newly diagnosed leptomeningeal metastases from non-small…
- Conditions
- Leptomeningeal Metastasis, Non-small Cell Lung Cancer Stage IV, Melanoma Stage IV
- Trial name
- IT-IO (NCT05598853)
- Testing
- intrathecal nivolumab and intrathecal ipilimumab
- Where
- 3 sites in Switzerland
- Volunteers
- 26 people
- Sponsor
- University of Zurich
Leptomeningeal Metastasis From Malignant Melanoma
A Clinical Trial to Assess the Safety & Efficacy of the Treatment of Patients With Metastasis From Malignant Melanoma - Treatment Consists of the Substances Lomustine (Capsules) & Cytarabine (Injected Into an Area Near the Spinal Cord), Accompanied by Radiotherapy of the Brain
The purpose of this trial is to test the safety and tolerance of the combination therapy with cytarabine, lomustine and radiotherapy in patients with leptomeningeal metastasis from malignant melanoma.
- Trial name
- NCT01563614
- Testing
- Brain radiotherapy (WBRT alone, SRT/SRS alone or WBRT plus SRT/SRS), Lomustine, Liposomal cytarabine
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- University Hospital, Bonn
B-cell Lymphomas
High-dose Sequential Chemoimmunotherapy for B-cell Lymphomas With Central Nervous System Involvement
This prospective trial will assess the activity and feasibility of a new high-dose methotrexate-based high-dose sequential chemotherapy combination in patients with B-cell lymphomas and CNS involvement at diagnosis or relapse.
- Trial name
- SCNSL1 (NCT00801216)
- Testing
- High-dose sequential chemotherapy and autologous transplant
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Andrés José Maria Ferreri
Meningeal Metastasis
Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001
Phase Ib/II clinical study on evaluating the safety, tolerance, biodistribution characteristics and preliminary efficacy of recombinant human nsIL12 oncolytic adenovirus injection (BioTT001) in the treatment of meningeal…
- Trial name
- NCT07264569
- Testing
- BioTTT001 injection
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Henan Cancer Hospital
Leptomeningeal Metastases
Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer
It has been proved that intrathecal chemotherapy is the main treatment strategy for leptomeningeal metastases. At present, the commonly used drugs for intrathecal chemotherapy include methotrexate, cytarabine, and liposomal…
- Trial name
- NCT03101579
- Testing
- Pemetrexed, Dexamethasone, Folic Acid
- Where
- China
- Volunteers
- 13 people
- Sponsor
- The First Hospital of Jilin University
Advanced Breast Cancer, HER2-positive Breast Cancer
DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease
This is a multicenter, international, open-label, single-arm, multicohort, two-stage optimal Simon's design, phase II clinical trial
- Conditions
- Advanced Breast Cancer, HER2-positive Breast Cancer, Brain Metastases, Leptomeningeal Metastasis
- Trial name
- DEBBRAH (NCT04420598)
- Testing
- Trastuzumab deruxtecan
- Where
- 16 sites in Portugal, Spain
- Volunteers
- 41 people
- Sponsor
- MedSIR
Brain Metastases
Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases
This clinical trial was designed to investigate the efficiency and toxicity of fractionated stereotactic radiotherapy(FSRT) combined with Temozolomide(TMZ) for refractory brain metastases.
- Trial name
- SRTRBM (NCT02654106)
- Testing
- Fractionated Stereotactic Radiotherapy, Temozolomide
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Cancer, Leptomeningeal Metastasis
Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.
This is a multicenter, interventional, prospective study among breast cancer patients with a suspicion of metastatic meningitis.
- Trial name
- NCT03974204
- Testing
- Cerebrospinal fluid and blood sample collection at the initial diagnostic assessment, Cerebrospinal fluid and blood sample collection if conclusions of initial diagnostic assessment are "Lack of evidence" according to EANO-ESMO classification, Cerebrospinal fluid and blood sample collection if conclusions of initial diagnostic assessment are "confirmed", "probable" or "possible", leading to leptomeningeal metastase specific treatment
- Where
- 2 sites in France
- Sponsor
- Centre Oscar Lambret
Leptomeningeal Metastasis
Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors
It has been proved that concurrent radiotherapy (RT) and intrathecal methotrexate (MTX) for leptomeningeal metastases (LM) from solid tumors with adverse prognostic factors showed great effectiveness and safety.
- Trial name
- NCT03082144
- Testing
- MTX, Ara-C, Radiotherapy
- Where
- China
- Volunteers
- 53 people
- Sponsor
- The First Hospital of Jilin University
Leptomeningeal Metastasis From Lung Cancer
Amivantamab Combined With Intrathecal Pemetrexed for LM From EGFR-Mutated Lung Adenocarcinoma
The goal of this clinical trial is to learn whether amivantamab combined with intrathecal pemetrexed is safe and may help treat leptomeningeal metastasis in adults with EGFR-mutant lung adenocarcinoma.
- Trial name
- NCT07744529
- Testing
- Amivantamab+ systemic/ intrathecal Pemetrexed
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Leptomeningeal Metastasis
Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM)
The purpose of this study is to learn whether the DNA from cancer tumor cells can be found in the cerebral spinal fluid (CSF) that bathes the brain and spinal cord of patients before malignant the cancer cells themselves are able…
- Trial name
- NCT02071056
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
NSCLC, Low Dose Radiotherapy
Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
This phase I study aims to investigate the safety and efficacy of whole brain low dose radiotherapy (WB-LDRT) combined with ICI and intrathecal chemotherapy for treatment of refractory meningeal metastasis of lung cancer.
- Conditions
- NSCLC, Low Dose Radiotherapy, PD-1 Inhibitor, Leptomeningeal Metastasis
- Trial name
- NCT06431685
- Testing
- Whole Brain Low Dose Radiotherapy, Pemetrexed, Sintilimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Sichuan University
Metastatic Breast Cancer, Leptomeningeal Disease
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD
A phase 2 non-randomized study to assess the safety and efficacy of the combination of tucatinib and trastuzumab with capecitabine for the treatment of leptomeningeal metastases in HER2-neu positive breast cancer.
- Trial name
- NCT03501979
- Testing
- Tucatinib, Trastuzumab, Capecitabine
- Where
- 9 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Alabama at Birmingham
Recurrent Childhood Medulloblastoma, Recurrent Childhood Ependymoma
Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors
The purpose of this research study is to test an experimental treatment method for recurrent or progressive brain tumors in children aged from 0-22 years.
- Conditions
- Recurrent Childhood Medulloblastoma, Recurrent Childhood Ependymoma, Childhood Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Abundant Neuropil and True Rosettes
- Trial name
- NCT02684071
- Testing
- Intra thecal methotrexate, topotecan, cyclophosphamide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Brain and Central Nervous System Tumors
Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs into the thin space between the lining of the spinal cord and brain may kill more tumor cells.
- Trial name
- NCT00003462
- Testing
- busulfan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Leptomeningeal Carcinomatosis
A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis
This study assesses the tolerability, safety, efficacy and pharmacokinetics of RTA 744 in recurrent neoplastic meningitis.
- Trial name
- LMD (NCT00527410)
- Testing
- RTA 744
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Biogen
Brain Metastasis, Meningeal Metastasis
QH101 Cell Injection in Patients With Brain, Brain (Spinal) Meninges, and Spinal Cord Metastatic Malignant Solid Tumors
QH101 is an allogeneic TCR-enhanced Vδ2 T cell therapy product engineered to express BTN protein-specific binding elements on the cell surface.
- Conditions
- Brain Metastasis, Meningeal Metastasis, Spinal Cord Metastasis
- Trial name
- NCT07656103
- Testing
- QH101 Cell Injection
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Solid Tumor, Solid Tumor, Adult
Pembrolizumab And Lenvatinib In Leptomeningeal Metastases
The purpose of this research is to examine if an experimental drug combination impacts the survival rate of individuals with Leptomeningeal Metastases This research study involves an experimental drug combination.
- Conditions
- Solid Tumor, Solid Tumor, Adult, Leptomeningeal Metastasis
- Trial name
- NCT04729348
- Testing
- Pembrolizumab, Lenvatinib
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital