Clinical trials: Nephrectomy, open to volunteers
Renal Cell Carcinoma
Transplantation of Reconstructed Renal Allografts Following Ex-Vivo Partial Nephrectomy
This study is designed to investigate a novel approach to offer more ESRD participants the benefits associated with renal transplantation by increasing the supply of available allografts
- Trial name
- NCT05725421
- Testing
- Donor Radical and Partial Nephrectomy, Kidney Transplantation, Laparoscopic Radical Nephrectomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Renal Cell Carcinoma (Kidney Cancer)
Virtual Renality: Assessing the Impact of Virtual Reality on Preoperative Planning in Renal Cancer Surgery
Rationale: Preoperative planning for both partial and radical nephrectomies using conventional CT imaging can be challenging due to complex renal anatomy and vascularization.
- Trial name
- NCT06960174
- Testing
- Virtual reality
- Volunteers
- 70 people
- Sponsor
- St. Antonius Hospital
Nonfunctioning Kidney, Renal Cell Carcinoma (RCC)
Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis
To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy .
- Trial name
- NCT07461090
- Testing
- open or laparoscopic nephrectomy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8
Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma
This phase III trial compares the effect of pembrolizumab to active surveillance after a surgical procedure to completely or partially remove a kidney (nephrectomy) in improving time without disease in patients with non-clear…
- Conditions
- Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
- Trial name
- NCT07689240
- Testing
- Biospecimen Collection, Bone Scan, Computed Tomography
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Living Kidney Donation, Hypertension
Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy
The goal of this observational study is to learn if PRAT thickness is a marker of visceral obesity and its influence on donors' kidney function and blood pressure in living kidney donors.
- Conditions
- Living Kidney Donation, Hypertension, Nephrectomy
- Trial name
- ProActive (NCT06886087)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postoperative Pain, Open Nephrectomy
Modified External Oblique Intercostal Plane Block Versus Erector Spinae Plane Block for Open Nephrectomy
This prospective, randomized, assessor-blinded clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) and Modified External Oblique Intercostal Plane Block…
- Trial name
- EOIPB-ON (NCT07726550)
- Testing
- Erector Spinae Plane Block, Modified External Oblique Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University
Anesthesia, Mechanical Ventilation
The Impact of Lumboscopy Versus Laparoscopy on Ventilatory Mechanics
There are several techniques for performing minimally invasive urological surgeries. Among them, laparoscopic surgery, robotic surgery, and lumboscopy are noteworthy (1).
- Conditions
- Anesthesia, Mechanical Ventilation, Respiratory Physiology
- Trial name
- NCT06776068
- Where
- 2 sites in Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Prostate Cancer (Adenocarcinoma), Renal Cancer
Comparison Between HUGO RAS Robotic Platform and Da Vinci Robotic Platform
The study is designed as a single-center, prospective, interventional, non-pharmacological, randomized, open-label, controlled trial with parallel groups.
- Trial name
- URO-ROBOT-2023 (NCT06844513)
- Testing
- Radical prostatectomy, Partial nephrectomy
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
RCC, Renal Cell Cancer
Comparison of Outcomes and Surgical Time Between Cortical and Medullary Suture vs. Medullary-Only Suture: Cortex Clinical Trial
Renal function preservation is a growing concern in the surgical management of kidney tumors, particularly with the rise in chronic kidney disease worldwide.
- Trial name
- CORTEX (NCT07190638)
- Testing
- Medullary-only suturing (single-layer), Suture, Medullary and cortical suturing (two-layer)
- Where
- 2 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Brazilian Institute of Robotic Surgery
Renal Carcinoma, Nephrectomy / Methods
R.E.C.K vs Exparel in Robotic Nephrectomy
The purpose of the study is to evaluate the efficacy of R.E.C.K (ropivacaine epinephrine clonidine ketorolac) vs Exparel during robotic partial and radical nephrectomy in a single institution, prospective, randomized trial.
- Conditions
- Renal Carcinoma, Nephrectomy / Methods, Pain Management
- Trial name
- NCT07092566
- Testing
- Ropivacaine HCL, Exparel, Epinephrine
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Wake Forest University Health Sciences
Renal Cell Cancer
The Value of a Convolutional Neural Network-Based Renal Artery Perfusion Model in Predicting Renal Function After Partial Nephrectomy: A Prospective Study
The goal of this observational study is to develop a CNN-based machine module to predict postoperative fractional renal function in people who are proposed to undergo partial nephrectomy.
- Trial name
- NCT06751498
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Shao Pengfei
Nephrectomy, Acute Kidney Injury
Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy
The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI.
- Conditions
- Nephrectomy, Acute Kidney Injury, Biomarker
- Trial name
- NCT07088874
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Kidney Neoplasm, Renal Mass up to 7cm
Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy
The goal of this prospective observational study is to learn about the use of a novel imaging technique called hyperspectral imaging in adult participants who are having surgery for removing a tumor from their kidney.
- Trial name
- HSI-Renal (NCT07803315)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Nephrectomy, Nephroureterectomy
Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy or Nephroureterectomy
Radical nephrectomy and nephroureterectomy are common operations for the treatment of renal cell carcinoma and upper tract urothelial carcinoma, respectively. However, acute kidney injury frequently occurs after surgery.
- Conditions
- Nephrectomy, Nephroureterectomy, Hemodynamic Management, Acute Kidney Injury
- Trial name
- NCT05149196
- Testing
- Targeted hemodynamic management, Routine care
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- Peking University First Hospital
Kidney Transplantation, Nephrectomy,Kidney Donation
A Qualitative Study on Gratitude and Recognition Toward Living Kidney Donors
Kidney transplantation is widely recognized as the best treatment for patients with end-stage renal disease. However, its development is limited by the persistent shortage of available organs.
- Trial name
- GRACE (NCT07254546)
- Testing
- Semi-structured qualitative interview
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal and Urinary Disorders, Renal Cancer
Application of the "Off-Clamp And Sutureless" Technique in Robot-Assisted Partial Nephrectomy
The detection rate of renal masses smaller than 7 cm has significantly increased in recent years. To preserve postoperative renal function to the greatest extent possible, guidelines from the European Association of Urology…
- Conditions
- Renal and Urinary Disorders, Renal Cancer, Renal Particial
- Trial name
- NCT07141225
- Testing
- Off-Clamp Sutureless Technique
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Shao Pengfei
Renal Cell Carcinoma (Kidney Cancer)
Radical Nephrectomy With vs Without Template Lymph Node Dissection in High-Risk Renal Cell Carcinoma (T-LND RCC)
The goal of this clinical trial is to learn if a more thorough lymph node removal surgery, called "Template Lymph Node Dissection," can help prevent cancer from returning and help patients live longer, compared to removing only a…
- Trial name
- RECLND (NCT07321197)
- Testing
- Template Lymph Node Dissection, Selective Lymph Node Resection
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University Second Hospital
Kidney Tumors, CKD
Kidney-protective Intervention With Salt Substitute After Kidney Tumor Surgery
This clinical trial is an open-label, randomized controlled study designed to evaluate the efficacyand safety of salt substitutes in protecting renal function after kidney tumor surgery, aiming toprovide dietary renal protection…
- Conditions
- Kidney Tumors, CKD, Salt Substitute, Nephrectomy
- Trial name
- NCT07062952
- Testing
- Salt substitute
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jinling Hospital, China
Renal Cell Carcinoma (Kidney Cancer), Postoperative Pain
QLESP Block for Pain Control in Robotic Partial Nephrectomy
The goal of this clinical trial is to learn if an ultrasound-guided nerve block called QLESP works to reduce pain and the need for strong pain medicines after robotic kidney surgery in adults.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Postoperative Pain, Nerve Block
- Trial name
- NCT07704970
- Testing
- ropivacaine (local infiltration), ropivacaine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Nephrectomy / Methods, Nephrectomy
Mapping Recovery, Quality of Life, and Physical Function After Partial and Radical Nephrectomy
Aim: To investigate recovery, quality of life, and physical function before and after partial or radical nephrectomy. To validate the Quality of Recovery-15 (QoR-15) questionnaire in a urological cohort and investigate whether…
- Trial name
- NCT07908277
- Testing
- None, observational study
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Herlev and Gentofte Hospital